Navigation Links
The immune system has protective memory cells, researchers discover
Date:11/28/2011

The immune system possesses a type of cell that can be activated by tissues within the body to remind the immune system not to attack our own molecules, cells and organs, UCSF researchers have discovered.

The discovery is likely to lead to new strategies for fighting a range of autoimmune diseases in which the immune system attacks and harms specific molecules and cells within us as well as for preventing transplant rejection, according to UCSF researchers who report their findings in the November 27 online edition of the journal Nature.

The cells tracked by the UCSF researchers circulate in the blood and are counterparts of the memory cells that help ward off microbial foes following vaccination or repeated exposure to the same pathogen.

UCSF immunologist and chair of the Department of Pathology Abul Abbas, MBBS; Michael Rosenblum, MD, PhD, an assistant professor with the UCSF Department of Dermatology; and UCSF postdoctoral fellow Iris Gratz, PhD, used a mouse model of autoimmune disease to discover a role in immune system memory for cells called activated T regulatory cells.

They found that over time a tissue within the body in this case, skin defends itself from autoimmune attack by protectively activating a small fraction of T regulatory cells.

"It's a novel concept that tissues remember," Abbas said. "Subsequent exposure to the same protein that elicited autoimmunity in that tissue may lead to less severe inflammatory disease."

Autoimmune diseases, ranging from minor to severe, affect an estimated 50 million Americans. Immunologists had for decades blamed these diseases on faulty functioning of immune cells known as lymphocytes, including the cells that make antibodies that normally target foreign proteins found on infectious disease pathogens.

In autoimmune disease, lymphocytes may be directed against "self" proteins. In multiple sclerosis, for example, lymphocytes make anti
'/>"/>

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Recipients immune system governs stem cell regeneration
2. Bacteria responsible for common infections may protect themselves by stealing immune molecules
3. VTT identified specific bacteria which precede autoimmune diabetes
4. What role do cytokines play in autoimmune diseases?
5. Source found for immune system effects on learning, memory
6. Xencor Initiates Phase 1 Study of XmAb®5871 Therapeutic Antibody for the Treatment of Autoimmune Diseases
7. Cleveland Clinic study discovers new targets for treating inflammatory, autoimmune diseases
8. La Jolla Institute discovers previously unknown cell interaction key in immune system attacks
9. Humans and sharks share immune system feature
10. Scientists discover a master key to unlock new treatments for autoimmune disorders
11. Researchers on the trail of a treatment for cancer of the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... DURHAM, N.C. -- When you accidentally touch a hot ... know the basic neural circuits involved in sensing and ... out the molecular players. , Duke researchers have made ... molecule involved in pain in worms, and have built ... Sept. 2 in Nature Communications , may help ...
(Date:9/1/2014)... quality in the U.S. has improved steadily in recent ... overall dietary quality remains poor and disparities continue to ... new study from Harvard School of Public Health (HSPH). ... date that the extensive efforts by many groups and ... payoff, but it also indicates that these efforts need ...
(Date:9/1/2014)... minutes after birth, every child in the U.S. undergoes ... of conditions, including sickle cell disease. Thousands of children ... meaning many suffer and die from the disease each ... halt to at least some of those deaths. ... working in the lab of George Whitesides, the Woodford ...
Breaking Biology News(10 mins):Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3
... created to provide a haven for both protected species ... Gothenburg have analysed species living on the seabed (benthic ... marine areas require special protection., , "It,s not possible ... park. That,s why I,ve done what experienced mushroom pickers ...
... This release is available in German . ... the carbohydrates they produce through photosynthesis in the leaves. However, ... heart to help transport this vital fuel. Instead, they use ... with colleagues from the Carnegie Institution for Science in California, ...
... of 34 institutions in 15 countries contributing to the measurements ... network, InGOS. , The network focuses on providing accurate information ... for a more vigorous climate action. In order to ... of greenhouse gas emissions is essential and not only ...
Cached Biology News:Life on Kosterhavet's seabed analyzed 2Sugar pump in plants identified 2Sugar pump in plants identified 3DTU is participating in a European network on measurement of greenhouse gases 2
(Date:8/30/2014)... (PRWEB) August 31, 2014 The ... a professional and in-depth study on the current ... Global and China. , The report provides a ... and industry chain structure. Global market analysis and ... focus on history, developments, trends and competitive landscape ...
(Date:8/29/2014)... According to a new market report published ... market was valued at USD 3,754.6 million in 2012 and ... 2019at a CAGR of 5.9% from 2013 to 2019. , ... is afflicted by bone and joint disorders, and this number ... has and will continue to increase the demand for orthobiologics. ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Three ... Energy's 2014 Hydrogen Production R&D Award ... by splitting water using sunlight. , Shared with ... and the University of Nevada, Las Vegas (UNLV), ... developing models of photoelectrochemical solar-hydrogen production and corrosion ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... deep underground carries no significant threat to human health, despite ... Researchers found that the risk of death from poisoning ... rocks is about one in 100 million far less ... from the University of Edinburgh studied historical data on deaths ...
... University-University of Oregon Center for Sustainable Materials Chemistry, born ... moving into a second phase under a new five-year, ... through its Centers of Chemical Innovation Program, will allow ... and development and boost efforts to translate basic-level discoveries ...
... The Albert and Mary Lasker Foundation, ... research, announced today the winners of the 2011 Lasker Awards ... Horwich for basic medical research, Tu Youyou for ... of Health for public service. The Lasker Awards – considered ...
Cached Biology Technology:Health fears over CO2 storage are unfounded, study shows 2Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 2Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 3Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 42011 Lasker Awards Honor Medical Research Pioneers 22011 Lasker Awards Honor Medical Research Pioneers 32011 Lasker Awards Honor Medical Research Pioneers 42011 Lasker Awards Honor Medical Research Pioneers 52011 Lasker Awards Honor Medical Research Pioneers 62011 Lasker Awards Honor Medical Research Pioneers 7
... SYBR Green II RNA gel ... gel stain that has bright fluorescence when ... gels, making it ideal for use with ... scanners or standard UV transilluminators. A 500 ...
... records analyzes and reports the data from any ... the a chart recorder. The final data is ... The end-point selection is automatic for Systolic, Mean, ... computed. The user is always in the position ...
... is taking automated patch clamping to a new ... to generate thousands of high quality data points ... in ion channel drug discovery and safety testing. ... afforded by conventional patch clamping can now be ...
... Reagents for the differentiation of mouse ... cell bodies exist in the midbrain, where ... nigra, the ventral tegmental area, and the ... rise to extensive forebrain dopamine innervation ( ...
Biology Products: