Navigation Links
The hitchhiker antigen: Cause for concern?
Date:10/23/2013

e author, Dr. Missag Parseghian, who develops clinical antibodies at Rubicon Biotechnology, introduces readers to a recent survey by the ENCODE consortium of commercial histone-targeting antibodies and how their data highlights the detrimental effects of hitchhiker antigens. His observations may have researchers thinking about the purity of the commercial antibodies sitting in their lab refrigerators. The problem, he says, may be prevalent in a wide array of research areas, not just the areas of chromatin, auto-immune and histone research highlighted here.

"I have been working with antibodies for over 25 years, both as a consumer who uses them in my research and as a scientist working for companies that manufacture them as therapeutics, and what has always struck me about antibodies is the variation in their performance from one lot to the next. Especially when working with antibodies generated from a small research lab and later from a commercial supplier," explained Dr. Parseghian. "Not that one or the other group produces a superior product, rather the same antibody produced by two different groups can show tremendous variation. Understanding and eliminating this variation is critical for successful development of antibody-based biologic agents as drugs."


'/>"/>

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Making eye contact doesnt always help your cause
2. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
3. Research team uncovers root cause of multiple myeloma relapse
4. Specific sugar molecule causes growth of cancer cells
5. Researchers uncover genetic cause of childhood leukemia
6. Stomach bacteria switch off human immune defences to cause disease
7. NIH scientists describe how anthrax toxins cause illness, death
8. Bacterial toxins cause deadly heart disease
9. Chanel, UCSBs corpse flower, blooms and causes a big stink
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. CSI-style DNA fingerprinting tracks down cause of cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... A new study from UC San Francisco is the ... stressors accumulate overtime and accelerate cellular aging, these negative ... exercising and sleeping well. , "The study participants ... telomere shortening than the ones who didn,t maintain healthy ... said lead author Eli Puterman, PhD, assistant professor in ...
(Date:7/28/2014)... the United States have a circulatory problem of the ... and may even require surgery in serious cases. This ... in turn, limb amputation. , At The University of ... scientists tested a non-surgical preventative treatment in a mouse ... increased blood circulation. Their proof-of-concept study appears in ...
(Date:7/28/2014)... a wild relative of the domestic tomato, has been ... labs headed by Professors Neelima Sinha and Julin Maloof ... new genome information may help breeders produce tastier, more ... the journal Nature Genetics , was lead by ... The UC Davis labs carried out work on the ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... it comes to producing more offspring, larger female hyenas outdo ... University researchers, which appears in Proceedings of the Royal ... way to measure spotted hyenas, size. "This is the ... lifetime selection on a large carnivore," said MSU graduate student ...
... , NEW YORK (March 23, 2011)The job of promoting conservation ... the birds, according to the authors of a new bird ... and Editora Horizonte in Sao Paulo, Brazil., Published in Portuguese ... Central Brazil" highlights the bird life of one of the ...
... A new research report published online in The FASEB ... high sugar and high fat diets have babies who are ... report, which used rats, this happens because the high fat ... brain,s reward pathway, altering food preferences. Not only does this ...
Cached Biology News:Larger female hyenas produce more offspring 2WCS releases 'Birds of Brazil' 2WCS releases 'Birds of Brazil' 3'Junk food' moms have 'junk food' babies 2
(Date:7/29/2014)... particle be separated from its properties? On July 29, ... results of the first Cheshire Cat experiment, separating a ... in Orange, CA, and Vienna University of Technology. , ... grin," thought Alice in Wonderland, "but a grin without ... saw in my life!" Alice,s surprise stems from her ...
(Date:7/29/2014)... has created a new way of manufacturing microstructured ... made by self-assembly of carbon nanotubes, could exhibit ... mechanical stiffness and strength, or the ability to ... have demonstrated that mechanical forces can be used ... and that we can independently control the ...
(Date:7/29/2014)... , July 29, 2014  Pomerantz LLP is investigating ... ("Impax" or the "Company") (NASDAQ: IPXL).  Such investors are ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... officers and/or directors have violated Sections 10(b) and 20(a) ... On July 29, 2014, Impax Laboratories, Inc. (the ...
(Date:7/29/2014)... 29, 2014 According to the ... Imaging), Analytics (Image Analysis Software), Delivery Modes (Web Based/Cloud ... & Trends to 2018", published by MarketsandMarkets, analyzes and ... such as North America , ... and the Rest of the World (RoW). ...
Breaking Biology Technology:The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4A new way to make microstructured surfaces 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3
... Oct. 26 AMN Healthcare Services,Inc. (NYSE: ... is,scheduled to make a presentation on Thursday, November ... BIOCOM Investor Conference 2007 taking place at the ... (Logo: http://www.newscom.com/cgi-bin/prnh/20060718/LATU121LOGO ) Susan R. ...
... Salugen, Inc., a personalized health,and wellness company ... release activator] results in significant,reductions in weight, ... population in,the Dietary Investigation to Evaluate Treatments ... Deficiency Syndrome (RDS) at the,Second Bruce Ames ...
... PURE Bioscience (OTC,Bulletin Board: PURE), creators of ... a revolutionary new hard surface,disinfectant which kills Staph/MRSA ... Company will present at the Biocom Investor Conference,on ... Marriott Del Mar. Michael L.,Krall, CEO, will discuss ...
Cached Biology Technology:AMN Healthcare Services to Present at the BIOCOM Investor Conference 2007 2Salugen's Award-Winning Research on Using DNA Information to Customize Nutritional Supplementation for Weight Loss Presented at the Second Annual Bruce Ames International Symposium on Nutritional Genomics at the University of California, Davis 2PURE Bioscience to Present at Biocom Investors Conference 2PURE Bioscience to Present at Biocom Investors Conference 3PURE Bioscience to Present at Biocom Investors Conference 4
Mouse IL-31 RA Biotinylated Affinity Purified PAb...
... 8 micro-bore tubes to 1 outflow Single-cell ... Rapid (several millisecond) solution change Very ... , Solid construction 360, 250 and ... For mounting on any micromanipulator Available in ...
... High Five cells (BTI-TN-5B1-4) derived from ... been shown to be capable of ... recombinant proteins compared to other insect ... following features:- -Rapid doubling time as adherent ...
... Promega Flipper® Racks are ideal for storage ... tubes. These polypropylene racks withstand extreme temperatures, ... storage. They may also be autoclaved for ... two-sided; one side accommodates 0.5ml microcentrifuge tubes, ...
Biology Products: