Navigation Links
The hitchhiker antigen: Cause for concern?
Date:10/23/2013

Since antibodies first attained prominence as research reagents in modern biological science labs, researchers have been perplexed as to why one production lot can differ significantly from the next, in terms of performance. Poor antibody performance has caused the loss of countless hours of research, to say nothing of the mental anguish of the researchers themselves. An antigen is a substance that stimulates the production of antibodies.

Now that antibodies are being widely exploited for clinical purposes, the problem of poor antibody performance goes beyond inconvenience to researchers and may threaten patients in a number of ways, including misdiagnosis of disease by pathologists using antibodies to characterize tissue biopsies; disposal of antibody production lots by manufacturers because of the apparent lack of potency; and misinterpretation of research results leading to incorrect conclusions about mechanisms of action for some diseases, which can be costly to pharmaceutical companies pursuing the wrong leads during drug development.

A new article just published in the journal Biochemistry and Cell Biology titled: "Hitchhiker antigens: Inconsistent ChIP results, questionable immunohistology data, and poor antibody performance may have a common factor" describes the problem. It claims that antibodies being manufactured today in large biological systems, whether it is a bioreactor filled with mammalian cells or a living organism, such as a rabbit or a goat, may often have a significant proportion of the lot "contaminated" with the very antigens they are designed to target. The antigens contaminating the antibodies can be thought of as "hitchhikers". This is only a problem if the antibody is designed to target a cellular protein or structure that is already present in the biological system in which it is being made, but such antibodies are increasingly common and are used for research and in medicine.

In this article, th
'/>"/>

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Making eye contact doesnt always help your cause
2. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
3. Research team uncovers root cause of multiple myeloma relapse
4. Specific sugar molecule causes growth of cancer cells
5. Researchers uncover genetic cause of childhood leukemia
6. Stomach bacteria switch off human immune defences to cause disease
7. NIH scientists describe how anthrax toxins cause illness, death
8. Bacterial toxins cause deadly heart disease
9. Chanel, UCSBs corpse flower, blooms and causes a big stink
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. CSI-style DNA fingerprinting tracks down cause of cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 According to a new ... Software, Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, ... Forecast to 2020", published by MarketsandMarkets, defines and segments ... various segments. The global PIAM Market is estimated to ... by 2019, at a CAGR of 14.9 % from ...
(Date:8/4/2015)... , Aug. 04, 2015 ... ) has announced the addition of the ... Software, and Service), Sub-Segment (Computer Forensics, Network ... Tool Types, Service, Vertical and Region - ... their offering. By Component (Hardware, ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den 10. ... afholdt af BGI fra den 22. - 25. oktober i ... Konferencen fejrer sin 10-års fødselsdag i år. Siden starten ... indflydelsesrige årlige møder på ,omik,-feltet, og er en af ... ICG-10 fokuserer på nylige gennembrud og fremskridt ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... Korea Advanced Institute of Science and Technology (KAIST) and ... on February 20th, 2013 the Master Research and Collaboration ... development of carbon management between the two entities. ... of the Memorandum of Understanding (MOU) between KAIST and ...
... orthopaedists and a wide number of specialists concerned with ... Asia-Pacific,s key clinical bone event in 2013. The ... cooperation with the Hong Kong Osteoporosis Foundation and the ... December 12-15, 2013 in Hong Kong. More than ...
... (February 26th, 2013) Canadian agriculture is faced ... risks and uncertainties. An expert panel convened by ... water and land resources in Canada can be ... effective land and water management strategies, adopting effective ...
Cached Biology News:Launched the Saudi Aramco-KAIST CO2 Management Center in Korea 2Report: 'Water and Agriculture in Canada: Towards Sustainable Management of Water Resources' 2
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Israel Biomedical Sensors Market - Growth, Trends & Forecasts ... The Israel Biomedical Sensors market is estimated at $0.19 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:8/31/2015)... Aug. 31, 2015  RXi Pharmaceuticals Corporation (NASDAQ: ... discovering and developing innovative therapies primarily in the ... the 30-day review period following the filing of ... indications with the U.S. Food and Drug Administration ... active. Logo -  http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:8/31/2015)... LabStyle Innovations Corp. (OTCQB: DRIO), developer ... it recently closed a round of funding totaling ... support the global rollout and initial U.S. commercial ... management solution that includes novel software applications combined ... device, and for working capital purposes. The Dario ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... There’s a ... Minerva is the first commercially available new FDA approved system in the last ... rate of 92%, the high Amenorrhea (zero bleeding) rate of 66%, the high Patient ...
Breaking Biology Technology:Israel Biomedical Sensors Market 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 2LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 3LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 4U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3
... , , , , , The programming example given below shows a , ... , , , , , ... Explanation, , , ... Temperature control for the , block., ...
... , , , , , ... Variable heating and cooling rates, which can be programmed as desired with , ... aligned to the temperature. , , ... it may be necessary to heat , up carefully after annealing. , ...
... , , , , , , ... only) , , ... gradient may be programmed , with ... The most common application is the determination of the optimal annealing , ...
Cached Biology Technology:Title 2
ready-to-use solution...
... MS/MS analysis & visualization ... across multiple samples. Combine ... for increased confidence. Get ... information from your MS/MS ...
... Synthetic peptide derived from the N-terminal ... dog and orangutang occludin proteins. ... protein. Reactivity: Human (positive controls: ... rat mouse dog and orangutang is ...
Anti-ZFP-38/RU49 Family: Zinc Finger Peptide Sequence: SVKVEDKDFPSTCSKK...
Biology Products: