Navigation Links
The hitchhiker antigen: Cause for concern?
Date:10/23/2013

Since antibodies first attained prominence as research reagents in modern biological science labs, researchers have been perplexed as to why one production lot can differ significantly from the next, in terms of performance. Poor antibody performance has caused the loss of countless hours of research, to say nothing of the mental anguish of the researchers themselves. An antigen is a substance that stimulates the production of antibodies.

Now that antibodies are being widely exploited for clinical purposes, the problem of poor antibody performance goes beyond inconvenience to researchers and may threaten patients in a number of ways, including misdiagnosis of disease by pathologists using antibodies to characterize tissue biopsies; disposal of antibody production lots by manufacturers because of the apparent lack of potency; and misinterpretation of research results leading to incorrect conclusions about mechanisms of action for some diseases, which can be costly to pharmaceutical companies pursuing the wrong leads during drug development.

A new article just published in the journal Biochemistry and Cell Biology titled: "Hitchhiker antigens: Inconsistent ChIP results, questionable immunohistology data, and poor antibody performance may have a common factor" describes the problem. It claims that antibodies being manufactured today in large biological systems, whether it is a bioreactor filled with mammalian cells or a living organism, such as a rabbit or a goat, may often have a significant proportion of the lot "contaminated" with the very antigens they are designed to target. The antigens contaminating the antibodies can be thought of as "hitchhikers". This is only a problem if the antibody is designed to target a cellular protein or structure that is already present in the biological system in which it is being made, but such antibodies are increasingly common and are used for research and in medicine.

In this article, th
'/>"/>

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Making eye contact doesnt always help your cause
2. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
3. Research team uncovers root cause of multiple myeloma relapse
4. Specific sugar molecule causes growth of cancer cells
5. Researchers uncover genetic cause of childhood leukemia
6. Stomach bacteria switch off human immune defences to cause disease
7. NIH scientists describe how anthrax toxins cause illness, death
8. Bacterial toxins cause deadly heart disease
9. Chanel, UCSBs corpse flower, blooms and causes a big stink
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. CSI-style DNA fingerprinting tracks down cause of cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Most cancer deaths occur because of metastasis, yet ... has been slow. , "It,s been particularly challenging ... Taran Gujral, research fellow in systems biology at ... aren,t detected until after they,ve already metastasized." , ... culprit that should help researchers better understand how ...
(Date:11/5/2014)... show great diversity in their ability to identify scents ... differ in their perceptual evaluation of odors, with women ... , Sex differences in olfactory detection may play ... connected to one,s perception of smell, which is naturally ... superiority has been suggested to be cognitive or emotional, ...
(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
... announced today that Oligonol, manufactured by Amino Up Chemical ... of the SupplySide West 2011 Scientific Excellent Award. The ... October 12, 2011 in Las Vegas at The Venetian ... with new ingredients or technologies, as well as those ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... -- Green checkered flag . . . ...
... 10th-14th, more than a hundred scientists from twenty-four countries ... and reservoirs, including what can be done to keep ... competing demands. The meeting is being organized by the ... of limnologists, ecologists, information technology experts, and engineers who ...
Cached Biology News:Oligonol receives Supplyside West 2011 scientific Excellence Award 2Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 2Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 3Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 4Fate of lakes focus of international meeting in Sunapee, N.H. 2
(Date:11/21/2014)... 2014 /CNW/ - Aequus Pharmaceuticals Inc. (the "Company" ... has closed a brokered private placement offering (the ... million.  Cormark Securities Inc. and Clarus Securities Inc. ... for a syndicate of agents that also included ... the "Agents"). Concurrently with the Brokered Offering, the ...
(Date:11/21/2014)... , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... nine month periods ended September 30, 2014.  Biorem,s complete 2014 third ... www.sedar.com ). Financial Summary:Three-months ended September 30, ... per share data) , 2014 , 2013 ... 2,282 , 5,281 , 6,715 , ...
(Date:11/18/2014)... 2014 RPS Diagnostics (RPS®) – ... today announces its third annual partnership of the ... Smart About Antibiotics Week from November 17-23. , ... campaign designed to highlight the coordinated efforts of ... and for-profit partners to provide education about the ...
(Date:11/18/2014)... 2014 pH measurement and control is ... pharmaceutical, chemical, and food and beverage industries. But what ... how do pH sensors work? METTLER TOLEDO has produced ... process industries with these questions and more. , METTLER ... the process industries. The actual sensor, the pH electrode, ...
Breaking Biology Technology:Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2
... on the basis ... Mass., Sept. 10 Hyaluron Contract,Manufacturing (HCM), a leading ... and biotechnology industries, announced,today that it has been selected ... Award. HCM is one of five companies from the,greater ...
... Development of New Route to Administer GAMMAGARD LIQUID(TM) ... Collaboration Valued at Up to $47 Million, ... International Inc. (NYSE: BAX ) and Halozyme ... have entered into an agreement to apply,Halozyme,s proprietary ...
... BERKELEY HEIGHTS, N.J. and RALEIGH, N.C., Sept. ... focused clinical,research organization, today announced the appointments ... Biostatistics and Christopher,Gregory, Ph.D as Scientific Affairs-Director. ... Srinivasan and Gregory, both highly,experienced professionals in ...
Cached Biology Technology:Hyaluron Contract Manufacturing Named a 2007 Economic Impact Award Finalist 2Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 2Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 3Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 4Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 5Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 6Baxter and Halozyme Announce Collaboration for Development of Subcutaneous GAMMAGARD LIQUID(TM) Administration Using Enhanze(TM) Technology 7Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 2Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 3Clinsys Clinical Research, Inc. Announces Key Hires, Rajagopalan Srinivasan, Ph.D, to Strengthen Global Biostatistics Service Offering and Christopher Gregory, Ph.D, to Scientific Affairs 4
... offers high performance miniature stepper motors available ... 34 frame sizes. These space-efficient 1.8 2-phase ... applications, including medical instrumentation, medical devices, drug ... Meets a wide range of customer ...
... have been designed to save time and ... interested in eliminating the recycling and resterilizing ... individually packaged, RNase/DNase free, non-pyrogenic and antistatic. ... product number, created to easily match Cornings ...
... bioassays for interferons are cytopathic effect inhibition ... assays. The neutralization assay measures the ... of the cytokine. Sample types include; tissue ... In these assays, one unit is defined ...
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
Biology Products: