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The genome's 3-D structure shapes how genes are expressed
Date:6/23/2013

cation that the three-dimensional structure of the genome can influence the splicing of genes."

"We can infer that the genome is folded in such a way that the promoter region the sequence that initiates transcription of a gene is located alongside exons, and they are all presented to transcription machinery."

"This supports a new way of looking at things, one that the genome is folded around transcription machinery, rather than the other way around. Those genes that come in contact with the transcription machinery get transcribed, while those parts which loop away are ignored."


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Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

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