Navigation Links
The genome's 3-D structure shapes how genes are expressed
Date:6/23/2013

Scientists from Australia and the United States bring new insights to our understanding of the three-dimensional structure of the genome, one of the biggest challenges currently facing the fields of genomics and genetics. Their findings are published in Nature Genetics, online today.

Roughly 3 metres of DNA is tightly folded into the nucleus of every cell in our body. This folding allows some genes to be 'expressed', or activated, while excluding others.

Dr Tim Mercer and Professor John Mattick from Sydney's Garvan Institute of Medical Research and Professor John Stamatoyannopoulos from Seattle's University of Washington analysed the genome's 3D structure, at high resolution.

Genes are made up of 'exons' and 'introns' the former being the sequences that code for protein and are expressed, and the latter being stretches of noncoding DNA in-between. As the genes are copied, or 'transcribed', from DNA into RNA, the intron sequences are cut or 'spliced' out and the remaining exons are strung together to form a sequence that encodes a protein. Depending on which exons are strung together, the same gene can generate different proteins.

Using vast amounts of data from the ENCODE project*, Dr Tim Mercer and colleagues have inferred the folding of the genome, finding that even within a gene, selected exons are easily exposed.

"Imagine a long and immensely convoluted grape vine, its twisted branches presenting some grapes to be plucked easily, while concealing others beyond reach," said Dr Mercer. "At the same time, imagine a lazy fruit picker only picking the grapes within easy reach.

"The same principle applies in the genome. Specific genes and even specific exons, are placed within easy reach by folding."

"Over the last few years, we've been starting to appreciate just how the folding of the genome helps determine how it's expressed and regulated,"

"This study provides the first indi
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Athletic frogs have faster-changing genomes
2. Researchers announce GenomeSpace environment to connect genomic tools
3. Differences in the genomes of related plant pathogens
4. Thirty teams compete to interpret three families genomes
5. The first goat genome sets a good example for facilitating de novo assembly of large genomes
6. Sequencing hundreds of chloroplast genomes now possible
7. FASEB SRC announces conference registration open for: Mobile DNA in Mammalian Genomes
8. Mitochondrial mutations: When the cells 2 genomes collide
9. BGI Tech develops novel Ultra-Deep de novo assembly solution for heterozygous genomes
10. Studies reveal structure of EV71, a virus causing childhood illnesses
11. Crystal structure of archael chromatin clarified in new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... most kids will hear that drinking milk helps make their bones ... these messages foster the idea that if something is good for ... in the Journal of Consumer Research , when children hear ... it. , "We predicted that when food is presented to children ... goal such as learning how to read or count, they would ...
(Date:7/22/2014)... MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical ... School of Nursing, contributed samples used in a ... with schizophrenia and also suggesting a possible link ... Biological insights from 108 schizophrenia-associated genetic loci, was ... , available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html., ...
(Date:7/22/2014)... side of meerkats which sees them prevent their daughters ... a new study. , Research into the desert creatures ... many adult helpers shows that the alpha female can ... The study shows how this way of life, also found ... effective despite its sinister side. , Dominant meerkats control ...
Breaking Biology News(10 mins):LSUHSC contributes to work identifying new DNA regions associated with schizophrenia 2
... Many of society,s most challenging health issues, including obesity, ... University of Missouri researchers are examining the multiple facets ... from medicine and research to policy and law to ... in the Mizzou Advantage (During a three-year process, MU ...
... of the Key West, Fla., population over 1,000 people ... 2009, according to a report from the Centers for Disease ... After three initial locally acquired cases of dengue were ... Department of Health conducted a study to estimate the potential ...
... Detecting oral cancer in its earliest stages can save ... early detection has been difficult. Case Western Reserve ... human beta defensin-3 (hBD-3), which may serve as an early ... and associated with the early stages of oral cancer. ...
Cached Biology News:Food for our future -- it's more than what's for dinner 2Food for our future -- it's more than what's for dinner 3Report suggests nearly 5 percent exposed to dengue virus in Key West 2CWRU dental researchers discover human beta defensins-3 ignite in oral cancer growth 2
(Date:7/22/2014)... 22, 2014  The Broad Institute today announced ... Ted Stanley aimed at galvanizing scientific ... based on molecular understanding to hundreds of millions ... The Stanley commitment – the largest ever in ... research in general – will support research by ...
(Date:7/22/2014)... , 22. Juli 2014 Qforma, ein ... die Ernennung von Marcus Bergler zum General Manager ... hat die europäischen kommerziellen Aktivitäten von Qforma bereits ... sich Qforma anschloss, war er in Positionen als ... als Vertriebsteam-Leiter Deutschland bei IMS Health und als ...
(Date:7/21/2014)... Lawrence Livermore National Laboratory ... Las Positas College (LPC) recently established a 24-month ... training for veterans, officials recently announced. , The ... is designed to help veterans develop the ... and establishes a pipeline of qualified candidates for ...
(Date:7/21/2014)... EUGENE, Ore. (July 21, 2014) The yield ... of Oregon have developed a low-energy, solution-based mineral substitution ... that could find use in electronics and alternative energy ... on the cover of the July 21 issue of ... most citations of research in the inorganic and nuclear ...
Breaking Biology Technology:$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2
... Mass., March 17 The pro bono healthcare ... ), has announced that its newly instituted Safe ... Lutheran Health System of La Crosse, Wisconsin. The ... outstanding accomplishments in safe patient handling, safe lifting, ...
... Pharmaceuticals Inc., a specialty pharmaceutical company, announces the ... Vice President of the Ferring International PharmaScience Center ... Pharmaceuticals Inc. Dr. Korner was formerly Vice ... and Gastroenterology therapeutic areas, as well as Product ...
... 19, 2009 at 11:00 AM ET LIVINGSTON, N.J., ... Inc. (OTC Bulletin Board: MLSS), the recognized leader in ... file its 2008 year-end results for the 12 months ... Exchange Commission on Tuesday, March 17, 2009. Having ...
Cached Biology Technology:Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 2Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 3Dr. Paul Korner Promoted to Senior Vice President of Ferring International PharmaScience Center U.S. 2Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 2Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 3