Navigation Links
The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation
Date:5/17/2013

May 17, 2013, Shenzhen, China---- Why Tibetan antelope can live at elevations of 4,000-5,000m on the Qinghai-Tibetan Plateau? In a collaborative research published in Nature Communications, investigators from Qinghai University, BGI, and other institutes provide evidence that some genetic factors may be associated with the species' adaption to harsh highland environments. The data in this work will also provide implications for studying specific genetic mechanisms and the biology of other ruminant species.

The Tibetan antelope (Pantholops hodgsonii) is a native of the high mountain steppes and semi-desert areas of the Tibetan plateau. Interestingly, it is the only member of the genus Pantholops. Tibetan antelope is a medium sized antelope with the unique adaptations to against the harsh high-altitude climate. For non-native mammals such as humans, they may experience life-threatening acute mountain sickness when visiting high-altitude regions.

In this study, researchers suggest that Tibetan antelopes must have evolved exceptional mechanisms to adapt to this extremely inhospitable habitat. Using next-gen sequencing technology, they have decoded the genome of Tibetan antelope and studied the underlying genetic mechanism of high-altitude adaptations.

Through the comparison between Tibetan antelope and other plain-dwelling mammals, researchers found the Tibetan antelope had the signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission, indicating that gene categories involved in energy metabolism appear to have an important role for Tibetan antelope via efficiently providing energy in conditions of low partial pressure of oxygen (PO2).

Further research revealed that both the Tibetan antelope and the highland American pika have signals of positive selection for genes involved in DNA repair and the production of ATPase. Considering the exposure
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. The DOE Joint Genome Institute expands capabilities via new partnerships
2. Scientists sequence genome of sacred lotus, which likely holds anti-aging secrets
3. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
4. Mapping the embryonic epigenome
5. Genome sequencing provides unprecedented insight into causes of pneumococcal disease
6. A new cost-effective genome assembly process
7. Turtle genome analysis sheds light on the development and evolution of turtle-specific body plan
8. CNIO researchers capture the replication of the human genome for the first time
9. Saint Louis University, University of Toronto biologists help decode turtle genome
10. Genome study suggests new strategies for understanding and treating pulmonary fibrosis
11. Coelacanth genome surfaces
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Oklahoma biology professor will study the unique bioelectric signaling ... eventually benefit people,s health. The OU researcher is ... required to produce the signals used to map the ... at a rate of 500-600 discharges a second throughout ... electric fish are extreme, but necessary for survival. , ...
(Date:9/19/2014)... regulate their symbiotic relationship with soil bacteria by ... plant structure from leaves into the roots to ... roots. This collaborative study was conducted by researchers ... Graduate University for Advanced Studies (SOKENDAI), and the ... , Legumes, an important plant family which ...
(Date:9/18/2014)... SAN ANTONIO, September 18, 2014 New research into ... which causes a severe hemorrhagic disease in humans similar ... factors essential for CCHFV infection. This discovery has the ... against the pathogen. , The research, reported ... PLoS Pathogens and conducted by scientists at the ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Research milestone in CCHF virus could help identify new treatments 2
... N.Y. (Tuesday, April 1, 2008) Identifying genes ... the mouse used to be a monumental task. ... it effective for even the smallest laboratories. This ... ( www.cshprotocols.org/TOCs/toc4_08.dtl ) highlights a method for screening the ...
... Challenges and Promise of Cell-Based Therapies is ... medicine using stem cells. The opening plenary session will ... will be followed by four plenary sessions that will ... musculoskeletal, and metabolic diseases and disorders. It will close ...
... 2008Biotechnology companies are focusing on the development of ... diagnostic tests for cancer, reports Genetic Engineering and ... forward, a much stronger and targeted emphasis on ... in the April 1 issue of GEN ( ...
Cached Biology News:Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution 2Challenges and promise of cell-based therapies 2
(Date:9/19/2014)... , September 19, 2014 Biotech ... development of emerging drug systems and advanced Laboratory Instrumentation. ... and Company (NYSE: BDX ), Thermo Fisher ... Inc. (NASDAQ: RGDO ), Sangamo Biosciences Inc. ... HOLX) Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ...
(Date:9/19/2014)... St. Paul, Minnesota (PRWEB) September 19, 2014 ... representatives from related food industries will gather October ... Meeting at the Rhode Island Convention Center in ... exhibition will feature the work of food scientists, ... development, quality control, and food production management. To ...
(Date:9/18/2014)... HealthTronics, Inc ., a leading ... and services, announced that a poster related to ... external beam radiotherapy (EBRT) is being presented at ... (MAAUA) Annual Meeting in Baltimore, Maryland September 18-21, ... and External Beam Radiation as Treatments for Localized ...
(Date:9/18/2014)... Ireland , September 18, 2014 ... and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has ... "Biocompatible Materials - Global Strategic Business ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes ... in US$ Million by the following ...
Breaking Biology Technology:Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... Largest Technology Matchmaking Event in the US Comes to Houston, ... 3-7, 2009 at the George R. Brown Convention Center, ... (NSTI), and the Clean Technology and Sustainable Industries,Organization (CTSI), today ... place May 3-7, 2009 at the George R. Brown,Convention Center ...
... New Boston Area Facility, NEW YORK, Oct. 27 ... is pioneering the pre-disease collection,processing and long-term storage of ... it has closed on a private placement financing,in the ... in launching,its adult stem cell collection network in the ...
... one Silver Bernays Mark of Merit award, for superior ... Industry Organization,s (BIO) 2008 BIO International Convention. The ... awards for the media kit it developed for Ichor ... in support of the Transportation Corridor Agencies, Toll Road ...
Cached Biology Technology:TechConnect World 2009 Matches Tomorrow's Technology Solutions with Today's Business Needs for Clean-Technology, Biotechnology and Nanotechnology 2TechConnect World 2009 Matches Tomorrow's Technology Solutions with Today's Business Needs for Clean-Technology, Biotechnology and Nanotechnology 3NeoStem Secures $250,000 in an Above Market Financing and Expands Its Relationship With New England Cryogenic Center, Inc. 2NeoStem Secures $250,000 in an Above Market Financing and Expands Its Relationship With New England Cryogenic Center, Inc. 3Gable PR Honored by PRSA San Diego Chapter with Three Awards for Client Programs 2Gable PR Honored by PRSA San Diego Chapter with Three Awards for Client Programs 3
... to Protein A and, until recently, no readily ... IgM purification. Standard methods for IgM purification generally ... effective for removing all of the major impurities ... Pierce has developed an easy-to-use affinity matrix ...
... the Moticam 2300 camera (MC2300) attaches to ... or trinocular port. Included in the standard ... 2.0ML software offers quick and accurate image ... resolution for examination or documentation purposes. The ...
... trademark of Merck KGaA. Physical form: Solution in 50% ... mM MgCl 2 , and 20 mM NaCl Preparation ... DNA to acid-soluble oligonucleotides equivalent to a ΔA 260 ... at 37 C (reaction volume 2.625 ml). Assay: ...
... StabilCoat Immunoassay Stabilizer is an aqueous ... and other non-toxic chemicals in a PBS ... 7.4. This product does not contain ... the conformation and activity of dried protein ...
Biology Products: