Navigation Links
The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
Date:3/10/2009

Polymorphisms are variations in genes which can result in changes in the way a particular gene functions and thus may be associated with susceptibility to common diseases. In a new study in Psychological Science, a journal of the Association for Psychological Science, psychologist Tina B. Lonsdorf and her colleagues from the Karolinska Institutet in Sweden and the University of Greifswald in Germany examined the effect of specific polymorphisms on how fear is learned and how that fear is subsequently overcome.

Many symptoms of anxiety disorders are thought to be learned and research on fear conditioning (a method of learning to fear a particular stimulus) shows that individuals diagnosed with anxiety disorders are quick to learn to fear a stimulus but have a difficult time getting rid of that fear. In this study, the researchers focused on polymorphisms in two genes thought to play a role in anxiety disorders: the serotonin transporter gene and the gene for the enzyme COMT.

Serotonin is a brain chemical involved in mood regulation. The serotonin transporter, which is the target of selective serotonin reuptake inhibitors (SSRI) used to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different versions that differ in their length. The shorter version of the gene leads to less serotonin being cleared away and is also associated with higher neuroticism scores and anxious behavior. The COMT enzyme is involved in breaking down dopamine, a brain chemical important for learning, motivation and seeking rewards. A specific polymorphism in this gene results in higher levels of extracellular dopamine in the prefrontal cortex, leading to enhanced working memory but also greater levels of anxiety.

In this experiment, volunteers were shown a picture (A) and then immediately received a mild electric shock. They were also shown another picture (B) that was never associated with a shock.
'/>"/>

Contact: Barbara Isanski
bisanski@psychologicalscience.org
Association for Psychological Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study examining role of genetics and environment in type 1 diabetes
2. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
3. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
4. New research helps explain genetics of Parkinsons disease
5. Modern genetics vs. ancient frog-killing fungus
6. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
7. American College of Medical Genetics receives $13.5M NIH contract
8. How do race, genetics and health-care disparities affect spread of HIV?
9. Genetics reveals big fish that almost got away
10. Study finds connections between genetics, brain activity and preference
11. The genetics of the white horse unraveled
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... lung, breast and pancreatic cancers also promote drug-resistance and ... California, San Diego School of Medicine have discovered a ... drug-resistant tumors that appears responsible for inducing tumor metastasis ... , The findings, published in the April 20, ... may point to new therapeutic opportunities for reversing drug ...
(Date:4/18/2014)... contraceptive pills in Peru found that 28 percent ... quality or falsified. Many pills released the active ... ingredient. One batch had no active ingredient at ... researchers at the Georgia Institute of Technology developed ... assess suspected counterfeit drugs and then characterize their ...
(Date:4/18/2014)... NC Ancient DNA adds a twist to the story ... to be published April 21 in the journal Proceedings ... from the bones of chickens that lived 200-2300 years ago ... ago domestic chickens may have looked far different from the ... of the traits we associate with modern domestic chickens -- ...
Breaking Biology News(10 mins):Cancer stem cells linked to drug resistance 2Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Ancient DNA offers clues to how barnyard chickens came to be 2
... that bacteria that cause diseases like bubonic plague and ... them infectious on or off. , Knowing how disease-causing ... may one day help scientists create drugs that control ... harmless, said Vladimir Svetlov, a study co-author and a ...
... how a protein from a bacterium acts like a cunningly ... of a new range of natural insecticides. It had been known that ... of a bacterium which they harbour inside their intestine. , The ... the nematode to kill and feed on the dead body of the ...
... reveal how illusions are produced in the brain's visual cortex, ... evidence of rapid integration of auditory and visual sensations in ... neural mechanisms by which visual perception can be altered by ... 12 edition of the Journal of Neuroscience. , When ...
Cached Biology News:Bacteria control how infectious they become, study finds 2Bacteria control how infectious they become, study finds 3Secret of worm's poison pill box protein could produce new natural insecticide 2Wired for sound: How the brain senses visual illusions 2
(Date:1/15/2014)... 2014 Two champions of science, technology, ... of an annual competition for middle and high school ... innovative STEM study. The competition presents students with real-world ... Engineering Aptitude, Mathematics, and Sciences is a program ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... - DAPTACEL vaccine is licensed for the entire immunization ... protect against diphtheria, tetanus, and pertussis -, ... Pasteur, the vaccines division of the sanofi-aventis Group,announced today ... DAPTACEL(R) (Diphtheria and Tetanus Toxoids and Acellular,Pertussis Vaccine Adsorbed) ...
... Silence Therapeutics plc,(AIM: SLN) today announces a collaboration ... a range of novel approaches for the delivery,of ... leading,expertise in the delivery of siRNA molecules, in ... siRNA in vivo using its,proprietary AtuPLEX technology. The ...
... March 13 Proteon Therapeutics, Inc.,( http://www.proteontherapeutics.com ... first-in-class pharmaceuticals to address the,medical needs of ... appointed,Gregory D. Phelps, a seasoned biopharmaceutical executive, ... brings more than 30 years of executive,leadership ...
Cached Biology Technology:U.S. FDA Licenses DAPTACEL(R) Vaccine for the Fifth Consecutive Dose in the Pediatric DTaP Immunization Series 2U.S. FDA Licenses DAPTACEL(R) Vaccine for the Fifth Consecutive Dose in the Pediatric DTaP Immunization Series 3U.S. FDA Licenses DAPTACEL(R) Vaccine for the Fifth Consecutive Dose in the Pediatric DTaP Immunization Series 4Silence Therapeutics and AstraZeneca Announce Collaboration to Develop Novel Approaches for siRNA Drug Delivery 2Silence Therapeutics and AstraZeneca Announce Collaboration to Develop Novel Approaches for siRNA Drug Delivery 3Proteon Therapeutics Appoints Experienced Biopharmaceutical Executive, Gregory D. Phelps to its Board of Directors 2
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
... stain is used to stain and visualize ... gels and does not interfere with northern ... transilluminator, the stain emits a red-orange signal ... or with a CCD camera-based gel documentation ...
... mitochondrial transmembrane potential is one ... that occur following induction of ... Kit utilizes a lipophilic cation, ... mitochondrial activity marker. MitoLight partitions ...
Biology Products: