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The genetic heart of the lipids
Date:12/7/2008

A new study presages a real aim of genetics: to look at whole populations to in order determine the significance of individual genetic variants for individual health. The research team, whose work is published in Nature Genetics, find six novel genetic variants that are associated with lipid levels, a common indicator of heart or artery disease.

The power of 'genetic microscopes' has increased because the methods are in place to study many thousands of DNA samples. This study, involving over 20,000 samples and researchers from a dozen European countries, is the first to find such lipidgene links by looking at the general population, rather than patients. The study is has been funded by an EU project, ENGAGE (www.euengage.org)

A search for a lipidgene link through such large numbers of unselected people has not been published before. The findings increase hopes for improved predictive diagnosis, which could lead to improved public health measures and early prescription of effective treatments.

"Since 2007, human genetics has achieved results that would have been unimaginable only five years ago," explains Professor Leena Peltonen, Head of Human Genetics at the Wellcome Trust Sanger Institute and senior author on the study, "but this is merely the dawn of new understanding. New, more powerful studies, such as our work on lipid levels, will illuminate the areas and the variants of our genome that play an important part in human disease."

Human geneticists often carry out case-control studies: researchers examine the genetics of people with a given disease (the 'cases') and compare them to the genetics of apparently unaffected people (the 'controls'). Such studies have been hugely successful in trailblazing discovery of genetic variants associated with common disease. However, because the people participating are not drawn at random, researchers are cautious about extrapolating their
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Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

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