Navigation Links
The genetic X-factor
Date:4/19/2009

A collaboration between more than 70 researchers across the globe has uncovered nine new genes on the X chromosome that, when knocked-out, lead to learning disabilities. The international team studied almost all X chromosome genes in 208 families with learning disabilities - the largest screen of this type ever reported.

Remarkably, the team also found that approximately 1𔃀% of X chromosome genes, when knocked-out, have no apparent effect on an individual's ability to function in the ordinary world. The publication in Nature Genetics - a culmination of five years of scientific collaboration - emphasises the power of sequencing approaches to identify novel genes of clinical importance, but also highlights the challenges researchers face when carrying out this kind of study.

Estimates suggest that the prevalence of learning disability is 2𔃁%. Learning disability is significantly more common in males than in females and genetic causes have long been sought on the X chromosome: males have only one X chromosome and so a gene mutation on the X is more likely to have an effect in males than in females.

"We sequenced 720 out of the approximately 800 known genes on the X chromosome in more than 200 families affected by X-linked learning disabilities," explains Professor Mike Stratton, from the Wellcome Trust Sanger Institute. "This is the largest sequencing study of complex disease ever reported."

In part because of their apparent effects in males, X-linked disorders have been well studied by geneticists over the past 25 years. Conceived by Dr Lucy Raymond, from the University of Cambridge, and Professor Mike Stratton, the collaborative study harnessed DNA sequencing to detect as many new abnormal genes as possible. In the future similar strategy will be used to find disease causing sequence variants implicated in other complex genetic diseases.

Some characteristics in common could be identified in patie
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic switch potential key to new class of antibiotics
2. Joint statement by German science organizations on green genetic engineering
3. New nucleotide could revolutionize epigenetics
4. For cancer cells, genetics alone is poor indicator for drug response
5. Is love at first sight real? Geneticists offer tantalizing clues
6. Major aspergillus genomics supplement published by journal Fungal Genetics and Biology
7. Ali Shilatifard and colleagues aim to clarify the definition of epigenetics
8. Researchers examine bacterial rice diseases, search for genetic solutions
9. Jonathan Berg, M.D., Ph.D. awarded Richard King Trainee Award for Best in Genetics in Medicine
10. Bad mix of bacterial remnants and genetics leads to arthritis
11. Margarita Saenz, M.D. is recipient of Genzyme/ACMGF Fellowship in Biochemical Genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/8/2015)... April 8, 2015  Infinisource, a leading provider ... and Morpho, a leading supplier of biometric identification ... the market,s most advanced biometrically-enabled time clock, the ... time clock is setting a bold, new standard ... for the small and mid-size employer. When connected ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... WEST LAFAYETTE, Ind. - Bacteria are able to build camouflaged ... by manipulating a natural cellular process. , ... a pair of proteins from the bacteria Legionella pneumophila , ... divert raw materials within the cell for use in building and ...
... from LIFE the Faculty of Life Sciences at the ... different growth pattern than non-breastfed children. Breastfeeding lowers the levels ... which means that growth is slightly slower. This is believed ... life. The PhD project is part of SKOT, ...
... camera trap video footage from the forests of Thailand ... country are paying off, according to the Wildlife Conservation ... several locations across Thailand,s Western Forest Complex over the ... the lives of tigers, Asian elephants, gaurs, sun bears, ...
Cached Biology News:Purdue scientists reveal how bacteria build homes inside healthy cells 2Purdue scientists reveal how bacteria build homes inside healthy cells 3Breastfeeding promotes healthy growth 2Candid video clips from Thailand show anti-poaching efforts saving wildlife 2
(Date:4/24/2015)... Mirego, leader in mobile strategies and solutions, is proud to ... for the all new Apple Watch. Made in ... these extensions will reinvent the way users receive and interact ... Available today in Canada ... that makes for an excellent buddy for business, health and ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
(Date:4/23/2015)... , April 23, 2015  Neurocrine Biosciences, Inc. ... will report its first quarter 2015 results before the ... will then host a live conference call and webcast to ... Thursday morning, April 30, 2015 at 8:00 a.m. Eastern ... access the live conference call by dialing 866-952-1906 (US) ...
(Date:4/23/2015)... 2015 Prospects for Leading Companies ... Report Details   We predict the global ... billion in 2015 and will grow at a CAGR of ... sectors around the world and increasing functional requirements for healthcare ... the global healthcare packaging market. A global ageing ...
Breaking Biology Technology:Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10
... DIEGO, Feb. 6 SGX Pharmaceuticals, Inc.,(Nasdaq: SGXP ) announced ... The conference information is as follows:, -- 10th Annual ... at 1:15 PM Eastern Standard Time at the Waldorf=Astoria, ... Conference: Tuesday, February 19, 2008 at 11:30 ...
... 5 BioSpecifics,Technologies Corp. (OTC Bulletin Board: BSTC) announced ... owed to it by its former CEO, Edwin H.,Wegman, ... Edwin H. Wegman,repaid the loan amount plus accrued interest ... of BioSpecifics, common stock to certain private,investors. The Estate ...
... Facility Services(R), LLC and,its family of companies ... the largest independent clinical technology maintenance and,management ... acquisition,is part of an aggressive growth strategy ... and accelerate the expansion of its,geographic footprint., ...
Cached Biology Technology:Linc Facility Services Acquires Morse Medical 2
... real-time observations of cell cultures under precise, ... different strain parameters in addition to a ... strain chamber used by the ST-195 is ... ST-195 can be used with Nikon, Olympus, ...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
... used in conjunction with the EasyCount System to ... The ViaSure Staining Reagent uses a mixture of ... Ethidium Bromide to identify live and dead cells, ... Slide 6 Multi-well Slide provides the ability ...
... Kit provides a powerful yet simple technology ... acids. The kit provides the heterobifunctional linkers ... quantifying conjugation efficiencies. It enables conjugation of ... other tags with a variety of proteins. ...
Biology Products: