Navigation Links
The gene family linked to brain evolution is implicated in severity of autism symptoms
Date:3/21/2014

The same gene family that may have helped the human brain become larger and more complex than in any other animal also is linked to the severity of autism, according to new research from the University of Colorado Anschutz Medical Campus.

The gene family is made up of over 270 copies of a segment of DNA called DUF1220. DUF1220 codes for a protein domain a specific functionally important segment within a protein. The more copies of a specific DUF1220 subtype a person with autism has, the more severe the symptoms, according to a paper published in the PLoS Genetics.

This association of increasing copy number (dosage) of a gene-coding segment of DNA with increasing severity of autism is a first and suggests a focus for future research into the condition Autism Spectrum Disorder (ASD). ASD is a common behaviorally defined condition whose symptoms can vary widely that is why the word "spectrum" is part of the name. One federal study showed that ASD affects one in 88 children.

"Previously, we linked increasing DUF1220 dosage with the evolutionary expansion of the human brain," says James Sikela, PhD, a professor in the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine. Sikela is the corresponding author of the study that was just published.

"One of the most well-established characteristics of autism is an abnormally rapid brain growth that occurs over the first few years of life. That feature fits very well with our previous work linking more copies of DUF1220 with increasing brain size. This suggests that more copies of DUF1220 may be helpful in certain situations but harmful in others."

The research team found that not only was DUF1220 linked to severity of autism overall, they found that as DUF1220 copy number increased, the severity of each of three main symptoms of the disorder -- social deficits, communicative impairments and repetitive behaviors became progress
'/>"/>

Contact: Dan Meyers
dan.meyers@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Merkin Family Foundation to fund next generation of Broad Institute scientists
2. Family history of liver cancer increases risk of developing the disease
3. Starting a family does not encourage parents to eat healthier
4. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
5. Family values
6. FirstMark Exhibiting and Presenting at the San Diego Academy of Family Physicians 55th Annual Postgraduate Symposium
7. Parkinsons disease gene identified with help of Mennonite family: UBC-VCH research
8. Helping family is key for social birds
9. Millipede family added to Australian fauna
10. CEVA, Rubidium Partner to Deliver Speech Processing Solutions based on the CEVA-TeakLite Family of DSPs
11. Bloomberg School receives $28 million for family planning advocacy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014  The 2014 Holiday Season may be ... Acuity Market Intelligence reports that the long anticipated ... Acuity forecasts that intensifying demand for smart phones, ... will drive a global market of 2.5 billion ... 2020.   According to Maxine ...
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... is not a steady march towards ever more sophisticated beings ... pointless, according to findings published by a team of researchers ... Department of Biochemistry. "Aristotle was the first to classify organisms ... of evolution continued this idea, with the concept of a ...
... Green technologies developed at The University of Nottingham have ... aimed at reducing global warming and tackling climate change. ... Rushlight Awards, attracting two prizes for innovations that will ... the developing world and help to make homes of ...
... are related to complex species including vertebrates (such as humans) ... an evolutionary link between simple animals such as jellyfish and ... implies that they have not always been as simple as ... and Acoelomorpha are very simple animals ...
Cached Biology News:New evolutionary research disproves living missing link theories 2Nottingham success in green technologies awards 2Nottingham success in green technologies awards 3Simple marine worms distantly related to humans 2
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a ... a network of more than 20 contributing fertility ... fast access to a national pool of frozen ... Associates of Memphis is the only fertility clinic in ... Dr. William Kutteh , director of Fertility Associates ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... 19, 2014 Bina Technologies, Inc. (Bina, ... they have been acquired by Roche (SIX: RO, ROG; ... held company that provides a big data platform for ... data for the academic and translational research markets.  Bina ... will continue to focus on development of their innovative ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... (AIM: NWBS and NWBT; OTC Bulletin Board: NWBO) (the,"Company") ... Rajhi Holdings,through the subscription of 1,000,000 new shares in ... share. The new stock is expected to be ... shares will not be tradable on the,Company,s OTC bulletin ...
... Relations, a Top 25 independent PR agency announced today the ... Group and the Yan Center for Corrective & Cosmetic Surgery, ... clientele. Both medical centers have tasked 5WPR to proactively direct ... Kent Holtorf and the Yan Center have selected 5W PR ...
... iCo Therapeutics Inc. (TSX-V: ICO) is pleased to announce ... financing provides the company with sufficient capital to develop ... clinical trial. iCo-007 is targeting the treatment of Diabetic ... company with additional working capital. iCo,s partner Isis Pharmaceuticals ...
Cached Biology Technology:Northwest Biotherapeutics Secures $700,000 Equity Financing 2The Holtorf Medical Group and Yan Center for Corrective & Cosmetic Surgery Tap 5W Public Relations 2iCo Therapeutics Closes $1.3 Million Private Placement 2iCo Therapeutics Closes $1.3 Million Private Placement 3
Schneider's Drosophila - Insect medium...
... x2 Dual-Binary Analytical System more than doubles ... and LC/MS. The fast analysis cycles of ... up to 100% in tandem mode. Difficult ... mode. Using backflush or heartcut configurations, on-line ...
... We can introduce random mutations to the gene ... then cloned into a vector of choice to ... Mutation frequency can be set to a desired ... of clones 106-108. Mutations can be restricted ...
... DNA preparations are prepared from customers ... 1mg to multi-gram scales. Each preparation ... and glycerol stocks are maintained to ... selection (Clonal selection includes screening colonies ...
Biology Products: