Navigation Links
The food-energy cellular connection revealed
Date:10/15/2009

Our body's activity levels fall and rise to the beat of our internal drumsthe 24-hour cycles that govern fundamental physiological functions, from sleeping and feeding patterns to the energy available to our cells. Whereas the master clock in the brain is set by light, the pacemakers in peripheral organs are set by food availability. The underlying molecular mechanism was unknown.

Now, researchers at the Salk Institute for Biological Studies shed light on the long missing connection: A metabolic master switch, which, when thrown, allows nutrients to directly alter the rhythm of peripheral clocks.

Since the body's circadian rhythm and its metabolism are closely intertwined, the risk for metabolic disease shoots up, when they are out of sync. "Shift workers face a 100 percent increase in the risk for obesity and its consequences, such as high blood pressure, insulin resistance and an increased risk of heart attacks," says Howard Hughes Medical Investigator Ronald M. Evans, Ph.D., a professor in the Salk Institute's Gene Expression Laboratory.

The researchers' findings, which are published in the Oct. 16, 2009, issue of Science, could have far-reaching implications, from providing a better understanding how nutrition and gene expression are linked, to creating new ways to treat obesity, diabetes and other related diseases. "It is estimated that the activity of up to 15 percent of our genes is under the direct control of biological clocks," says Evans. "Our work provides a conceptual way to link nutrition and energy regulation to the genome."

The clocks themselves keep time through the rhythmic waxing and waning of circadian gene expression on a roughly 24-hour schedule that anticipates environmental changes and adapts many of the body's physiological functions to the appropriate time of day. The most obvious one, the sleep-wake rhythm, is tightly linked to the night-day cycle. But so are physical activity and metabolism
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Too much of a good thing? Scientists explain cellular effects of vitamin A overdose and deficiency
2. New computer simulation helps explain folding in important cellular protein
3. Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
4. KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex
5. Model tissue system reveals cellular communication via amino acids
6. Cellular discovery may lead to targeted treatment for rare form of anemia
7. A budding role for a cellular dynamo
8. Tuning in on cellular communication in the fruit fly
9. Researchers identify new function of protein in cellular respiration
10. Dictyostelium cells shown to lay breadcrumb trail as first step in multicellular formation
11. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , 31 de julio de 2015 ... (ICG-10,  www.icg-10.org ) del 22 al 25 de octubre ... La conferencia celebra su décimo aniversario este ... convertido en una de las reuniones anuales más influyentes ... es una de las conferencias científicas más dinámicas, entusiastas ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... rubbed on the skin to reduce signs of aging and ... the first evidence of one of vitamin E,s normal body ... tears in the plasma membranes that protect cells from outside ... University researchers report in the journal Nature Communications ., ...
... is an adorable doe-eyed bat with a dark side it ... Tsang, a PhD student in ecology and evolutionary biology at The ... to a revolutionary way to help fund her research into how ... viruses can spread from flying foxes to humans by tracing the ...
... Researchers at the University of Delaware are examining tiny ... not only how these organisms adapt to the severe cold, ... The National Science Foundation study, led by Adam Marsh, ... Ocean, and Environment, also will compare the process of temperature ...
Cached Biology News:Scientists identify an innate function of vitamin E 2Crowdfunding science: Student raises cash online to follow a flying fox 2Crowdfunding science: Student raises cash online to follow a flying fox 3Will Antarctic worms warm to changing climate? 2Will Antarctic worms warm to changing climate? 3
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... infectious diseases has been discovered by researchers at the Keck Graduate Institute and ... previously untreatable diseases. , The findings were published online on August 27 by ...
(Date:9/1/2015)... DUBLIN , September 1, 2015 ... appointment of Sara Mathew to its Board of ... member of the Audit, Compliance & Risk Committee of the ... 1, 2015. Sara previously served as Chairman, President ... retiring in December 2013. During her 12-year tenure at D&B, ...
(Date:8/31/2015)... ... August 31, 2015 , ... In recent years, biodegradable plastics ... low carbon footprints and compostability. These properties can help in limiting the degradation ... basis of applications, the market for biodegradable plastics can be broadly segmented into ...
(Date:8/31/2015)... 31, 2015 Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... The Mexico Biomedical Sensors market is estimated at $0.20 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
Breaking Biology Technology:Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4Shire Appoints Sara Mathew to Board of Directors 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2
... into why and how nanowires take the form they ... future electronic components. PhD student Peter Krogstrup from the ... the sensational new theoretical model, which is developed in ... One of the most important components in future electronic ...
... How would you like to store all the films ever ... Magnets made of just a few metallic atoms could make ... also recently been proposed as components for spintronics devices. There,s ... been seen to work at temperatures a few hairs above ...
... Group, Inc.  (OTC Bulletin Board: MDXG ), ... biomaterial-based products and bioimplants processed from human amniotic membrane, ... 31, 2010. Full Year 2010 ResultsIn ... with the calendar year. Its prior fiscal year was ...
Cached Biology Technology:Major advance in understanding how nanowires form 2Heavy metals open path to high temperature nanomagnets 2MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Biology Products: