July 14, 2011 The Collaborative Cross (CC) represents a large collection of new inbred mouse strains created by the mouse genetics community aimed at revolutionizing the study of complex genetic traits and diseases. Derived from classical inbred strains and wild-derived strains, the CC captures nearly 90% of known genetic variation in laboratory mice, far surpassing more commonly used inbred strains. The CC is a tool to integrate studies of gene function and gene networks, allowing the prediction and testing of biological models based on the whole organism, critical to the development of personalized therapies for humans. Genome Research has published three articles online in-advance utilizing strains from the emerging Collaborative Cross mouse strains.
1. Collaborative Cross strains facilitate mapping of causative loci
In this work, Aylor and colleagues performed an experiment called the "the pre-CC study," the first genetic data and analysis from the emerging strains of the CC. Their investigation revealed that the genomes of CC strains are genetically diverse and contain balanced contributions from each founding strain. Highlighting the statistical power provided by the CC, Aylor et al. utilized ancestry information of the CC strains to map genetic loci for a Mendelian trait (white head-spotting), a complex trait (body weight), and a molecular trait (gene expression in the liver), demonstrating the ancestry-based approach to be superior to established marker-based methods for trait loci discovery.
Reference: Aylor DL et al. Genetic analysis of complex traits in the emerging collaborative cross. Genome Res. doi: 10.1101/gr.111310.110
2. Breeding effects in the Collaborative Cross
The development of the Collaborative Cross presents a unique opportunity to investigate how the breeding of inbred strains affects genetic structure and the diversity
|Contact: Peggy Calicchia|
Cold Spring Harbor Laboratory