Navigation Links
The first studies utilizing the Collaborative Cross mice are published in Genome Research
Date:7/14/2011

July 14, 2011 The Collaborative Cross (CC) represents a large collection of new inbred mouse strains created by the mouse genetics community aimed at revolutionizing the study of complex genetic traits and diseases. Derived from classical inbred strains and wild-derived strains, the CC captures nearly 90% of known genetic variation in laboratory mice, far surpassing more commonly used inbred strains. The CC is a tool to integrate studies of gene function and gene networks, allowing the prediction and testing of biological models based on the whole organism, critical to the development of personalized therapies for humans. Genome Research has published three articles online in-advance utilizing strains from the emerging Collaborative Cross mouse strains.

1. Collaborative Cross strains facilitate mapping of causative loci

In this work, Aylor and colleagues performed an experiment called the "the pre-CC study," the first genetic data and analysis from the emerging strains of the CC. Their investigation revealed that the genomes of CC strains are genetically diverse and contain balanced contributions from each founding strain. Highlighting the statistical power provided by the CC, Aylor et al. utilized ancestry information of the CC strains to map genetic loci for a Mendelian trait (white head-spotting), a complex trait (body weight), and a molecular trait (gene expression in the liver), demonstrating the ancestry-based approach to be superior to established marker-based methods for trait loci discovery.

Reference: Aylor DL et al. Genetic analysis of complex traits in the emerging collaborative cross. Genome Res. doi: 10.1101/gr.111310.110

2. Breeding effects in the Collaborative Cross

The development of the Collaborative Cross presents a unique opportunity to investigate how the breeding of inbred strains affects genetic structure and the diversity
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. First study into GM Atlantic salmon mating reveals danger of escape to wild gene pool
2. Scientists discover first gonorrhea strain resistant to all available antibiotics
3. From deadly E. coli to endangered polar bears: GigaScience provides first citable data
4. Broadlawns Installs First-in-Iowa Biometric Patient Identity Security System
5. For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs
6. First whole-genome lung cancer study by TGen and Virginia G. Piper Cancer Center set for conference
7. The loudest animal is recorded for the first time
8. New study documents first cookiecutter shark attack on a live human
9. First joint ESC/EAS guidelines for the management of dyslipidaemias
10. Prodigal plankton species makes first known migration from Pacific to Atlantic via Pole
11. Elsevier and ADSA announce winners of first annual Journal of Dairy Science Most Cited Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... Germany , August 6, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted display ... new solution, unprecedented quality and efficiency is brought to ... displays. For the first time, professionals and researchers can ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:7/31/2015)... China , 31 de julho de 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) será realizada pela BGI de 22-25 ... . A conferência está celebrando seu ... em 2006, a ICG se tornou uma das reuniões ... um dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... Research Ship James Cook have discovered a new set of ... Ocean. The discovery is the fourth made by the ... may be more common in our oceans than previously thought. ... mineral spires three metres tall, with shimmering hot water gushing ...
... autologous renal progenitor cells (RPCs), (kidney stem cells derived from ... a type of urinary infection that has reached the kidney ... The study, authored by a research team from the ... issue of Cell Medicine [1(3)] and is freely ...
... of Technology and the Northeast Georgia Medical Center are one ... sedation in hospital intensive care units (ICUs). They have developed ... patient,s level of sedation and can notify medical staff if ... have one of the most task-laden jobs in medicine and ...
Cached Biology News:More deep-sea vents discovered 2Stem cell transplants help kidney damage 2Researchers working toward automating sedation in intensive care units 2Researchers working toward automating sedation in intensive care units 3Researchers working toward automating sedation in intensive care units 4
(Date:8/26/2015)... (PRWEB) , ... August 26, 2015 , ... ... Solutions, announces today that a second US laboratory is to open in Manhattan, ... with the continued partnership and long-term growth of research and development through collaboration ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
(Date:8/26/2015)... HONG KONG , Aug. 26, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... Holdings Limited ("MO2"), an entity wholly owned by Mr. ... the Company, has acquired the outstanding shares (the "Shares") ...
(Date:8/26/2015)... ... 26, 2015 , ... The 2015 Epigenomics & Metabolomics Meeting in ... Asymmetrex to share the first report on progress with its crowdsourcing campaign ... adult tissue stem cells. , With a name like “H2A.Z asymmetry,” the new biomarker ...
Breaking Biology Technology:MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... Dr. Jay Kouba, a 25-year veteran of the chemical and ... Virent Energy Systems . , ,Virent, which recently entered into ... Shell Oil Co., is developing technologies that allow the renewable ... CEO of Metabolix, Inc. , a publicly traded Massachusetts ...
... the CEOs caught up in the scandals of WorldCom, ENRON, and ... & Grigsby . The people on this video make them look ... regard for people trying to make a living to support their ... there in the last couple of years that have not been ...
... things they didn't tell Jeanne Moreno when she joined ... years ago. Under the circumstances, she's just fine with ... officer to join a large, global business organization and ... aging and obsolete business applications, but compounding the challenge ...
Cached Biology Technology:A disgusting video: U.S. companies sell out Americans 2A disgusting video: U.S. companies sell out Americans 3A disgusting video: U.S. companies sell out Americans 4CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 2CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 3CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 4CIO Leadership Series: Snap-On's Moreno offers lessons in IT transformation 5
... matrix for the extraction of unwanted ... other macromolecules, Applications: ,Reducing octyl glucoside ... interaction of pure β-adrenergic receptor and ... SDS in 6 M urea/0.05 mM ...
... cells form from a hematopoietic stem cells ... to the bone surface and lowering the ... around 4.5. The bone mineral is then ... and function is controlled primarily by Macrophage ...
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
... Service includes 1. Scanning of gel(s) ... High-sensitive tryptic in-gel digestion and peptide ... MALDI-MS 5. Acquisition of PMF (Peptide ... ultraflex TOF/TOF) 6. Acquisition of PFF ...
Biology Products: