Navigation Links
The evolutionary foundation of genomic imprinting in lower vertebrates
Date:5/18/2009

A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary foundation of genomic imprinting exists in lower vertebrates and genomic imprinting should not be considered as a unique evolutionary event of mammals. The study is reported in volume 54 (Issue 8, April, 2009) of Chinese Science Bulletin.

Genomic imprinting has been identified in eutherians, marsupials and flowering plants, but no endogenous imprinted gene has been reported in other vertebrates and invertebrates. Therefore, genomic imprinting is thought a unique phenomenon of placental mammals and a regulatory mechanism to keep a balance of supply and demand for maternal nutrients between mother and fetus in mammalian species. However, how genomeic imprinting was originated, established and maintained during vertebrate evolution remains unclear.

In this study, the authors examined the methylation status of the teleost homologue of mammalian imprinting gene Igf2 during gametogenesis. Their results showed that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island was a parental differentially methylated region that was hypermethylated in sperm but unmethylated in eggs. The authors also indicated that, unlike mammalian imprinting gene DMR, the unmethylated DMR of maternal allele could not resist methylation reprogramming and started de novo methylation at the cleavage stage, while the paternal Igf2 allele appeared to maintain its paternal methylation imprints during embryogenesis. These results suggested that the parent-specific methylation of goldfish Igf2 DMR might be a primitive genomic imprinting in the early period of vertebrate evolution.

The investigation "provided the first molecular evidence that the evolutionary foundation of genomic imprinting exists in lower vert
'/>"/>

Contact: C. Luo
luoc@zju.edu.cn
86-571-882-06476
Science in China Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Analysis finds strong match between molecular, fossil data in evolutionary studies
2. Evolutionary origin of bacterial chromosomes revealed
3. Study of protein structures reveals key events in evolutionary history
4. Evolutionary biologist will study HIV with grant from AIDS research foundation
5. A revolutionary new model for Alzheimers disease
6. Clemson chemists present revolutionary teaching concepts
7. Pubic hair provides evolutionary home for gorilla lice
8. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
9. Dinosaur fossils fit perfectly into the evolutionary tree of life
10. Evolutionary process more detailed than previously believed, study shows
11. Scientists uncover evolutionary keys to common birth disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces ... CEO Conference on January 29 th at 10:30 ... CEO of NXT-ID will present and host a live ... wallet and its full suite of biometric technologies. Investors ...
(Date:1/22/2015)... CHICAGO , Jan. 9, 2015 Valid S.A. ("Company") ... the market in general the State of Washington,s ... contract for a new enrollment and central issuance system for ... The project planning and development will start ...
(Date:1/22/2015)... N.C. , Jan. 16, 2015  A man-made form ... memory and other mental capabilities in adults with mild ... pilot study led by researchers at Wake Forest Baptist ... adults diagnosed with amnesic mild cognitive impairment (MCI) or ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... published in the November issue of Nutrition Journal ... may have helped healthy, overweight people feel more satisfied and ... study was funded by the Hass Avocado Board. The ... Effect of Hass Avocado Intake on Post Ingestive Satiety, Glucose ...
... the relative rate of molecular evolution between humans and chimps with ... marches on at a steady pace in all creatures or if ... genetic code occur more rapidly in some groups than in ... Proceedings of the Royal Society B . The team chose ...
... 2014 Despite years of anti-smoking education and legislation, ... in the United States. In 2010, 25.2% of all ... use. While anti-tobacco efforts continue across the county, the ... a less harmful alternative to cigarettes and also as ...
Cached Biology News:New research: Effects of eating half an avocado with lunch on satiety & desire to eat between meals 2Of lice and men (and chimps): Study tracks pace of molecular evolution 2Of lice and men (and chimps): Study tracks pace of molecular evolution 3Perceived benefits of e-cigarettes may lead to higher experimentation rates 2Perceived benefits of e-cigarettes may lead to higher experimentation rates 3
(Date:3/2/2015)... Shimadzu Scientific Instruments will showcase several new ... marijuana analysis at the Pittcon 2015 conference and exhibition. ... the Ernest N. Morial Convention Center in New Orleans, ... to discuss laboratory challenges with Shimadzu’s technical experts and ... save time, money and effort in the lab. ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 In the ... industry has experienced robust growth. The industry, which ... industrial materials, energy resources and other goods, has grown ... government regulation. As a result, IBISWorld forecasts that industry ... to reach $946.8 million over the five-year period, including ...
(Date:3/2/2015)... 2015 Resilinc released online ... which summarizes and analyzes nearly 700 unique supply ... 24X7 global event monitoring and alert reporting service. ... free trial period of the email service to receive ... can negatively impact revenue, market share, customer satisfaction, and ...
(Date:3/2/2015)... Analyzing a puzzling multisystem disorder in ... syndrome, shedding light on key biological processes during ... to help caregivers manage the disorder, and may ... "This syndrome illuminates a very important pathway in ... controls many other genes," said study leader ...
Breaking Biology Technology:Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 2Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 3Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 2Resilinc Publishes 2014 EventWatch™ Supply Chain Disruption Annual Report 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 2New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 3New Genetic Syndrome Found, Arising from Errors in 'Master Switch' During Early Development 4
... Wis. - Mirus Bio Corp. , a Madison-based ... first outside the U.S., that covers a method of treating ... of genes. , ,The patent, titled "Intravascular Delivery of Nucleic ... therapeutic nucleic acids to body tissues via the blood stream ...
... in an elevator next to a venture capitalist who could ... thing about it yet. , ,You have 90 seconds ... Elevator Pitch Olympics, a yearly event at the Wisconsin ... dished out advice and a few hard knocks to hopeful ...
... and - to paraphrase Sally Field - "You like us, you ... there was a keen observation: that some of the companies debuted ... some of the technologies on the DEMO stage. Yet I suspect ... might argue, does not a company make. Or perhaps I should ...
Cached Biology Technology:Mirus granted European patent for gene therapy 29 tips for making 90 seconds count in an investment pitch 2Sometimes, features can make a company 2Sometimes, features can make a company 3
...
Anti-VDAC (Voltage-Dependent Anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
A powerful, easy-to-use solution, the SORVALL RC12BP Blood Processing System allows you to manufacture blood components quickly and cost-effectively while ensuring product quality, safety, and GMP co...
... Reverse Transcriptase is a recombinant Moloney ... MultiScribe Reverse Transcriptase is similar to ... its recommended usage. MuLV reverse transcriptase ... that uses single-stranded RNA as a ...
Biology Products: