Navigation Links
The evolutionary foundation of genomic imprinting in lower vertebrates
Date:5/18/2009

A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). These results indicate that the evolutionary foundation of genomic imprinting exists in lower vertebrates and genomic imprinting should not be considered as a unique evolutionary event of mammals. The study is reported in volume 54 (Issue 8, April, 2009) of Chinese Science Bulletin.

Genomic imprinting has been identified in eutherians, marsupials and flowering plants, but no endogenous imprinted gene has been reported in other vertebrates and invertebrates. Therefore, genomic imprinting is thought a unique phenomenon of placental mammals and a regulatory mechanism to keep a balance of supply and demand for maternal nutrients between mother and fetus in mammalian species. However, how genomeic imprinting was originated, established and maintained during vertebrate evolution remains unclear.

In this study, the authors examined the methylation status of the teleost homologue of mammalian imprinting gene Igf2 during gametogenesis. Their results showed that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island was a parental differentially methylated region that was hypermethylated in sperm but unmethylated in eggs. The authors also indicated that, unlike mammalian imprinting gene DMR, the unmethylated DMR of maternal allele could not resist methylation reprogramming and started de novo methylation at the cleavage stage, while the paternal Igf2 allele appeared to maintain its paternal methylation imprints during embryogenesis. These results suggested that the parent-specific methylation of goldfish Igf2 DMR might be a primitive genomic imprinting in the early period of vertebrate evolution.

The investigation "provided the first molecular evidence that the evolutionary foundation of genomic imprinting exists in lower vertebrates", said one of the journal reviewer.


'/>"/>

Contact: C. Luo
luoc@zju.edu.cn
86-571-882-06476
Science in China Press
Source:Eurekalert

Related biology news :

1. Analysis finds strong match between molecular, fossil data in evolutionary studies
2. Evolutionary origin of bacterial chromosomes revealed
3. Study of protein structures reveals key events in evolutionary history
4. Evolutionary biologist will study HIV with grant from AIDS research foundation
5. A revolutionary new model for Alzheimers disease
6. Clemson chemists present revolutionary teaching concepts
7. Pubic hair provides evolutionary home for gorilla lice
8. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
9. Dinosaur fossils fit perfectly into the evolutionary tree of life
10. Evolutionary process more detailed than previously believed, study shows
11. Scientists uncover evolutionary keys to common birth disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... systems are increasingly being developed with Wi-Fi connectivity to reduce the amount of ... room to room. In addition, compact mobile devices including infusion pumps, heart and ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... human cardiovascular cells for research and the development of cardiac regeneration therapies. ... generate large numbers of cardiomyocytes (hPSC-CMs). Due to varying differentiation efficiencies, further ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Vortex Biosciences ... “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ” in ... of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig at the ...
(Date:5/23/2017)... Boston, Massachusetts (PRWEB) , ... May 23, 2017 , ... ... is making a splash at this year’s Bio-IT World Conference and Expo ... Anzo Smart Data Lake® 4.0 solution. The Anzo Smart Data Lake is also ...
Breaking Biology Technology: