Navigation Links
The evolution of gene regulation
Date:5/26/2009

Even microbes are governed by the principle of supply and demand at least at the genetic level. Not all of their gene products, the blueprints for proteins, are required at all times. That means most of their genes only become active when they are needed, as is the case in higher organisms. In the simplest case, a transcription factor will activate the gene in question at the right time. Genes that are regulated in a somewhat more complex manner, on the other hand, are kept inactive by a repressor that is removed only when the gene is needed. Which of these two regulation mechanisms will develop is a question of demand, along the lines of a "use-it-or-lose-it" principle: if genes are frequently active, then, as a rule, they will be directly induced. Genes that encode more rarely used proteins, on the other hand, tend to be kept inactive by repressors. LMU physicist Ulrich Gerland and Professor Terence Hwa of the University of California have now demonstrated using computer simulations and theoretical analyses that another indeed opposing principle also comes into play: "wear-and-tear". According to this principle, direct activation can lead to harmful changes. "Which of the two principles prevails depends on evolutionary criteria such as the population size and the periods over which environmental changes take place," says Gerland. "Our study may serve as a useful basis for more detailed studies of the evolution of regulatory systems." (PNAS Early Edition, 22 Mai 2009)

Up until the middle of the 20th century, biochemists spent most of their efforts studying metabolism, i.e. obtaining energy from food. Less importance was given to the technically inexplicable question of how proteins were regulated as a response to internal and external signals. The biology of regulation only came into its own as an independent research field when technical progress opened the window to scientific analysis of DNA, the carrier of genetic traits, and to the sy
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U of Minnesota research reveals critical role of evolutionary processes in species coexistence
2. University of Florida study provides insight into evolution of first flowers
3. Computer model predicts brain tumor growth and evolution
4. The evolutionary foundation of genomic imprinting in lower vertebrates
5. U of Minnesota study finds high school teachers influence student views of evolution & creationism
6. Analysis finds strong match between molecular, fossil data in evolutionary studies
7. New nucleotide could revolutionize epigenetics
8. The story of X -- evolution of a sex chromosome
9. UBC study first to show evolutions impact on ecosystems
10. Evolutionary origin of bacterial chromosomes revealed
11. Texas Board of Education vote on the way evolution is taught could set national trend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/14/2015)... , May 14, 2015  Verificient Technologies, ... verification and online remote proctoring, announced a ... (SaaS) company and creator of the Canvas ... the two companies will benefit from the ... As a fully integrated multifactor ...
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2
... Assistance in Area of National Need program has awarded ... to support a new graduate fellowship training program in ... next three years. An additional 25 percent match ... Biology and K-State,s office of research and sponsored programs, ...
... University scientists have won a $1.5 million grant from ... A virus for clues that could lead to more ... year,s pandemic H1N1 variety, some seasonal varieties and the ... biochemists in the laboratory of Rice,s Jane Tao will ...
... are created each time a cell divides, they are not ... differ in the way they regulate them. New research now ... are directly linked to how they prepare for their next ... and the State University of New York, Stony Brook, may ...
Cached Biology News:K-State receives more than $780,000 to fund graduate students studying ecology, evolution, genomics 2Flu focus: NIH project aims for better drugs 2Checkered history of mother and daughter cells explains cell cycle differences 2Checkered history of mother and daughter cells explains cell cycle differences 3
(Date:5/25/2015)... BOSTON , May 26, 2015  PureTech, a ... toughest health challenges in disruptive ways, announced today that ... Foundation and former CEO of Pearson, has been appointed ... Senior Independent Director and that current Board member ... appointed Board Chairman. Dr. Ben Shapiro , PureTech,s ...
(Date:5/22/2015)... DUBLIN , May 22, 2015  Actavis plc ... of the U.S. Court of Appeals for the Second ... 2014 preliminary injunction requiring the Company to continue distribution ... Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   ... uphold this ruling, we intend to continue our strong ...
(Date:5/22/2015)... Baylor Research Institute (BRI) at Dallas ... in Phoenix, AZ , today announce ... treatments for patients with a broad range of cancers. Aligning ... clinical trials and access to technology to drive the development ... bedside across Baylor Scott & White Health,s 49 ...
(Date:5/21/2015)... 2015  Susan Hedstrom, Executive Director of the ... dedicated to supporting research to advance the understanding ... that FPWR has received the organization,s largest donation ... contributed $1 million in support of the organization,s ... "Our gift signifies our tremendous ...
Breaking Biology Technology:PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2
... SARcode Corporation has named Todd Creech as Chief Financial ... 1, 2011. Creech has been fulfilling both positions as ... (Photo: http://photos.prnewswire.com/prnh/20110214/FL47222LOGO ) "Todd ... finance and leadership roles and has demonstrated great success ...
... with phosphorus, a critical element in fertilizers and food, ... "can,t get no respect." Increasingly scarce, yet ... this essential component of our bones, our DNA, the ... oil on the endangered species list without change ...
... today announced the public launch of the Tufts Institute ... The Institute is a university-wide, global pharmaceutical ... portfolio of drug discovery and development partnerships. ... Tufts University School of Medicine and Tufts University,s Advancement ...
Cached Biology Technology:Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 2Todd A. Creech Named Chief Financial Officer and Vice President of Business Development for SARcode Corporation 3P Summit calls for a 'new alchemy' around phosphorus and food 2P Summit calls for a 'new alchemy' around phosphorus and food 3P Summit calls for a 'new alchemy' around phosphorus and food 4Tufts Launches Institute for Biopharmaceutical Partnerships 2Tufts Launches Institute for Biopharmaceutical Partnerships 3Tufts Launches Institute for Biopharmaceutical Partnerships 4
Sheep polyclonal to Melatonin ( Abpromise for all tested applications). Antigen: Melatonin Tg conjugate....
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
...
DNA fragmentation factor & Inhibitor of CAD...
Biology Products: