Navigation Links
The ends of mRNAs may prevent the beginnings of cancer
Date:8/20/2009

CAMBRIDGE, Mass. (August 20, 2009) The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

The finding from scientists at Whitehead Institute for Biomedical research is reported in the August 20 edition of Cell.

Proteins are made from templates that are copied from a cell's DNA. These templates, called messenger RNAs (mRNAs), comprise three sections. The middle section codes for the actual protein, while the beginning and end sections are known as untranslated regions (UTRs) because they do not code for any portion of the protein. Instead, the beginning section gets protein production started, while the tail section, called the 3'UTR, appeared simply to be along for the ride.

"This end of the mRNA is often not considered that important because if you put the beginning and middle of the mRNA into a cell, you get the right protein," says Christine Mayr, first author of the Cell paper and a former postdoctoral researcher in the lab of Whitehead Member David Bartel. "But now we know that this end often has a protein production regulatory program and in some cases can play a role in cancer."

A cell uses proteins in almost all of its processes, from cell division, to transporting essential molecules, to providing the cell's structure. Because the cell's protein production profile is tightly controlled and specific to the cell's type and stage in its life cycle, the over- or under-production of certain proteins can alter normal cellular function. These changes can include uncontrolled cell division and the ability to grow in the absence of a substrateboth defining traits of cancer cells.

When Mayr compared mRNAs produced in normal cells with those in cancerous cells, she noticed that the tail end of the cancer cells' mRNAs were cut short. In some cases, nearly 95% of the 3'UTR was missing.


'/>"/>
Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Controlling for size may also prevent cancer
2. Avocados may help prevent oral cancer, OSU study shows
3. Dietary calcium could possibly prevent the spread of breast cancer to bone
4. Bilberry extract -- can it help prevent certain cancers?
5. Preventing tuberculosis reactivation
6. Knocking out cell receptor may help block fat deposits in tissues, prevent weight gain
7. Scripps research team blocks bacterial communication system to prevent deadly staph infections
8. Frontiers in Cancer Prevention Research
9. NASA technology helps predict and prevent future pandemic outbreaks
10. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
11. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... Mass. (September 15, 2014) The so-called central ... makes proteinhas long provided a simplified explanation for ... living organisms. , In reality, of course, ... schema first articulated nearly 60 years ago by ... double-helix structure. For one, there are multiple types ...
(Date:9/15/2014)... cell division has evolved a simple, mechanical solution ... the Sept. 11 Science Express. ... counts and misalignments that lead to infertility, miscarriage, ... cell division cause these problems, but what exactly ... Marston of the Wellcome Trust Center for Cell ...
(Date:9/15/2014)... that a single group of microorganisms may be responsible ... the oceans, with implications for the global carbon cycle ... essential molecule required by most life on this planet, ... of microorganisms because it is so large and complex. ... maintaining the brain and nervous systems, as well as ...
Breaking Biology News(10 mins):Scientists discover RNA modifications in some unexpected places 2Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Researchers discover new producer of crucial vitamin 2
... to play in urgently-needed new treatments to fight the virulent ... Strathclyde in Glasgow, Scotland. The scientists found that ... in the Pacific region, was active against MRSA, which causes ... was either the underlying cause or a contributory factor in ...
... have developed a way of accurately predicting when women will ... difference between the predicted age and the actual age that ... a third of a year, and the maximum margin of ... Ramezani Tehrani will tell the 26th annual meeting of the ...
... new technology that allows scientists to monitor how individual cells ... researchers have uncovered a much larger spectrum of differences between ... act in a uniform fashion, as was previously thought. ... Markus Covert, PhD, assistant professor of bioengineering and senior author ...
Cached Biology News:Bees help to beat MRSA bugs 2Researchers develop accurate way to predict the age when women will hit the menopause 2Researchers develop accurate way to predict the age when women will hit the menopause 3Same types of cell respond differently to stimulus, Stanford study shows 2Same types of cell respond differently to stimulus, Stanford study shows 3
(Date:9/16/2014)... 2014 BlueInGreen® , a ... method for delivering dissolved gases into liquids, announced ... as a manufacturer’s representative firm to its sales ... for municipal water and wastewater applications in the ... was founded in 1992 and serves Quebec and ...
(Date:9/16/2014)... 16, 2014 CIRTEC Medical Systems’ Board ... as CEO of CIRTEC. , “I am delighted ... the Company.” noted Brian Highley. “The company has made ... strong organic growth over the past two years. The ... to improve and expand the services Cirtec offers its ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 ... initiatives to position themselves for their 89th ... labeling and encoding, Pharma Packaging Solutions is ... hardware and software and new procedures. Establishing ... Good Manufacturing Practices (cGMP), Pharma Packaging Solutions ...
(Date:9/16/2014)... Calif. , Sept. 16, 2014 /PRNewswire-iReach/ -- ... index (BMSi) test identifies patients with bone fragility ... Over 160 million people worldwide are at risk ... by today,s standard bone strength test, the DEXA ... 2014 American Society for Bone and Mineral Research ...
Breaking Biology Technology:BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3
... In light of an announcement made recently by Astellas Pharma ... that it had received a letter dated November 13, 2008 ... acquire CV Therapeutics at a price of $16.00 per share, ... After careful deliberation, with the assistance of its financial ...
... Alfacell Corporation (OTC Bulletin Board: ACEL) today reported that ... Food and Drug Administration (FDA) to discuss the company,s ... rolling New Drug Application (NDA) for the treatment of ... meeting, the FDA provided guidance to the company recommending ...
... Conference Call and Webcast Scheduled for Tuesday, February 3, ... (Nasdaq: NBIX ) announced today that the ... financial results after the Nasdaq market closes on Tuesday, ... conference call and webcast to discuss its financial results ...
Cached Biology Technology:CV Therapeutics Statement on Unsolicited Proposal From Astellas 2CV Therapeutics Statement on Unsolicited Proposal From Astellas 3Alfacell Provides ONCONASE(R) NDA Submission Update 2Alfacell Provides ONCONASE(R) NDA Submission Update 3Neurocrine Biosciences Announces Conference Call and Webcast to Present Fourth Quarter and Year End 2008 Financial Results 2
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Description: Proteinase K is a ... wide range of applications purified from the fungus ... the carboxyl group of N-substituted hydrophobic aliphatic and ... as a serine protease. Proteinase K is useful ...
... The H2OBIT™ is a fully licensed, high throughput, ... processing of up to 24 microplates. This equates ... plates. A robotic arm rapidly transfers ... resulting in temperature ramping times that are considerably ...
Biology Products: