Navigation Links
The endocannabinoids: Functional roles and therapeutic opportunities
Date:10/14/2007

Cannabis (marijuana) is the most widely produced plant-based illicit drug worldwide and the illegal drug most frequently used in Europe. Its use increased in almost all EU countries during the 1990s, in particular among young people, including school students. Cannabis use is highest among 15- to 24-year-olds, with lifetime prevalence ranging for most countries from 2040% (EMCDDA 2006).

Recently there has been a new surge in the level of concern about potential social and health outcomes of cannabis use, although the available evidence still does not provide a clear-cut understanding of the issues. Intensive cannabis use is correlated with non-drug-specific mental problems, but the question of co-morbidity is intertwined with the questions of cause and effect (EMCDDA 2006). Prevention is of importance in adolescents, which is underlined by evidence that early-onset cannabis-users (pre- to mid-adolescence) have a significantly higher risk of developing drug problems, including dependence (Von Sydow et al., 2002; Chen et al., 2005).

The illegal status and wide-spread use of cannabis made basic and clinical cannabis research difficult in the past decades; on the other hand, it has stimulated efforts to identify the psychoactive constituents of cannabis. As a consequence, the endocannabinoid system was discovered, which was shown to be involved in most physiological systems the nervous, the cardiovascular, the reproductive, the immune system, to mention a few.

One of the main roles of endocannabinoids is neuroprotection, but over the last decade they have been found to affect a long list of processes, from anxiety, depression, cancer development, vasodilatation to bone formation and even pregnancy (Panikashvili et al., 2001; Pachter et al., 2006).

Cannabinoids and endocannabinoids are supposed to represent a medicinal treasure trove which waits to be discovered.

What is the endocannabinoid system?

<
'/>"/>
Contact: Professor Raphael Mechoulam
mechou@cc.huji.ac.il
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Towards precise classification of cancers based on robust gene functional expression profiles
2. Software Tool for Converting Scientific Text into a Database of Functional Relationships
3. Physical and functional interaction of key cell growth molecules linked to cancer
4. Bone marrow cells can become functional gut lining cells
5. Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
6. Flies on speed offer insight into the roles of dopamine in sleep and arousal
7. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
8. New roles for growth factors: Enticing nerve cells to muscles
9. Master planners in brain may coordinate other areas roles in cognitive tasks
10. Sunflower speciation highlights roles for transposable elements in evolution
11. Study reveals candidate targets for anti-retroviral therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... A sleep-promoting circuit located deep in the primitive ... Discovered by researchers at Harvard School of Medicine and ... Sciences, this is only the second "sleep node" identified ... both necessary and sufficient to produce deep sleep. , ... the study demonstrates that fully half of all of ...
(Date:9/18/2014)... into the Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne ... similar to that caused by Ebolavirus, has identified new ... the potential to lead to novel targets for therapeutic ... reported in a paper published today in the journal ... the Texas Biomedical Research Institute and their colleagues, represents ...
(Date:9/18/2014)... of researchers from McGill University and the Quebec ... polyethylene ,microbeads, Canadian Journal of Fisheries and ... from cosmetics, household cleansers, or industrial cleansers, to ... to their small size and buoyancy, they may ... are a global contaminant in the world,s oceans, ...
Breaking Biology News(10 mins):No sedative necessary: Scientists discover new 'sleep node' in the brain 2Research milestone in CCHF virus could help identify new treatments 2Microplastic pollution discovered in St. Lawrence River sediments 2
... press release is available in French . ... are not slower but rather wiser than young brains, which ... according research undertaken at the University Geriatrics Institute of Montreal ... Univeristy of Montreal. "The older brain has experience and knows ...
... important processes during drilling operations. In deepwater drilling, controlling pressure ... the drilled hole can result in blowouts, leading to disastrous ... The deeper the well, the higher the pressure, and the ... drilling, when the pressure applied to balance the hydrocarbon pressure ...
... scientists and collaborators has identified a cellular protein that plays ... online today in separate studies in the journal Nature, ... world,s most deadly viruses. Ebola causes hemorrhagic fever ... humans. The virus is of concern both as a global ...
Cached Biology News:Clinical study shows young brains lack the wisdom of their elders 2A math-based model for deep-water oil drilling 2A math-based model for deep-water oil drilling 3Single protein, key to ebola virus infection, could aid in drug design 2
(Date:9/19/2014)... CORAL SPRINGS, Florida , September 19, 2014 /PRNewswire/ ... progress in medical technology, development of emerging drug systems ... (OTC: PBIO), Benton, Dickinson and Company (NYSE: ... TMO ), Regado Biosciences Inc. (NASDAQ: RGDO ... and Hologic Inc. (NASDAQ: HOLX) Pressure BioSciences, ...
(Date:9/19/2014)... SAN DIEGO , Sept. 19, 2014 ... engaged in the development of high-value and difficult to ... will be presenting at the 21 st Annual ... New York . Bertrand Liang , chief ... the company,s development programs and business strategy on Friday, ...
(Date:9/19/2014)... Barnhardt Manufacturing Company has ... Organic Cotton . The USDA Certified Biobased Product ... ingredients meets or exceeds levels set by USDA. Biobased ... or in significant part of agricultural, forestry, or marine ... cotton to be immediately identified as a USDA certified ...
(Date:9/19/2014)... Dublin ... announced the addition of the  "Micro Market Monitor ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... fastest-growing segments in the chromatography market. The market ... expected to reach $2.0 billion by 2019, at ...
Breaking Biology Technology:Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Pfenex to Present at Upcoming Industry Conference on September 26 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2
... 23 Eisai Corporation of,North America and its ... Food and Drug Administration (FDA) has approved a ... prevention of,chemotherapy-induced nausea and vomiting (CINV). ALOXI Capsules ... prevention of acute nausea and,vomiting following initial and ...
... WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology and ... in China and the United,States, today announced that ... of Synthetic Chemistry., (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... Dr. Shuhui Chen, Chief Scientific,Officer of WuXi PharmaTech., ...
... Aug. 22 /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals (NASDAQ: OGXI ... sodium, received Fast Track designation from the U.S. ... for progressive,metastatic prostate cancer. OGX-011 is currently completing ... breast cancer, and is designed to,inhibit the production ...
Cached Biology Technology:FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 3WuXi PharmaTech Promotes Dr. Rujian Ma to VP of Synthetic Chemistry 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 2FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 3FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals' Lead Product Candidate OGX-011 4
... Kit #4 detects apoptosis on the ... permeability of cell membranes. This kit contains ... iodide nucleic acid stains. YO-PRO-1 stain selectively ... cells and labels them with moderate green ...
Request Info...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
1+ mg expected yield of purified protein, expressed in insect cells - excludes cDNA...
Biology Products: