Navigation Links
The egg makes sure that sperm don't get too old
Date:3/25/2009

In contrast to women, men are fertile throughout life, but research at the Sahlgrenska Academy, University of Gothenburg, Sweden, has now shown that a fertilising sperm can get help from the egg to rejuvenate. The result is an important step towards future stem cell therapy.

The risk of chromosomal abnormalities in the foetus is highly correlated to the age of the mother, but is nearly independent of the age of the father. One possible explanation is that egg cells have a unique ability to reset the age of a sperm.

"We are the first to show that egg cells have the ability to rejuvenate other cells, and this is an important result for future stem cell research", says Associate Professor Tomas Simonsson, who leads the research group at the Sahlgrenska Academy that has made this discovery.

Each time a cell divides, the genetic material at the ends of the chromosomes becomes shorter. The ends of the chromosomes, known as "telomeres", are important for the genetic stability of the cell and they act as a DNA clock that measures the age of the cell. The cell stops dividing and dies when the telomeres become too short.

The discovery that the egg cell can extend the telomeres of a fertilising sperm cell is important in the development of stem cell therapy. Stem cell therapy involves replacing the cell nucleus in unfertilised egg with a nucleus from a somatic cell that has come from a patient who needs a stem cell transplantation. As soon as the cell has divided a few times, it is possible to harvest stem cells that are then allowed to mature to the cell type that the recipient needs.

"The genetic stability of the transplanted cells has been a serious concern up until now, and it was feared that the lifetime of these cells would depend on the age of the cell nucleus that was transferred. Our results suggest that this is not the case", says Tomas Simonsson.


'/>"/>

Contact: Elin Lindstroem Claessen
elin.lindstrom@sahlgrenska.gu.se
46-708-294-303
University of Gothenburg
Source:Eurekalert

Page: 1

Related biology news :

1. Tobacco makes medicine
2. Liking sweets makes sense for kids
3. Oh baby, interventional radiology makes childbirth safer
4. Red wine vs. white? It makes no difference when it comes to breast-cancer risk
5. Mount Sinai Hospital researcher makes stem cell breakthrough
6. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
7. Rett Syndrome Research Trust advisor makes significant discovery
8. Tree lizard’s quick release escape system makes jumpers turn somersaults
9. Biophysical Reviews makes debut in 2009
10. Our unconscious brain makes the best decisions possible
11. Fly guy makes memory breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... environmental scientists and engineers, led by Clemson University ... $5.25 million grant from the U.S. Department of ... make a direct positive impact on South Carolina ... of radioactive contaminants. , "Understanding the scientific and ... environmental aspects of nuclear technologies is imperative if ...
(Date:9/30/2014)... farm runoff in Hawaii is causing tumors in endangered ... study, published Tuesday in the peer-reviewed open-access journal ... up in algae that the turtles eat, promoting the ... internal organs. , Scientists at Duke University, the University ... (NOAA) conducted the study to better understand the causes ...
(Date:9/30/2014)... news release is available in German . ... in their behavioural response to risky situations such as ... for Ornithology now found in a long-term study on ... with both metabolic rate and ambient temperature. High metabolic ... behaviour, as in these scenarios birds were more likely ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2
... MAYWOOD, Ill. -- Most people know that too much sodium ... suggests that people trying to lower their blood pressure should ... effect to sodium. Researchers found that the ratio of ... cardiovascular disease than sodium or potassium alone. "There ...
... millions of genetic mutations has revealed four new DNA "hotspots" ... researchers led by the University of Michigan and including several ... in a just-published study. Appearing Jan. 25 in ... two other previously identified DNA sites, discovered by researchers at ...
... press release is available in French . ... study conducted by Universit de Montral researchers on ... treatment plant has revealed the presence of chemotherapy ... Bezafibrate (cholesterol reducing medication), enalapril (hypertension medication), methotrexate ...
Cached Biology News:Cutting salt isn't the only way to reduce blood pressure 2Researchers identify 4 genetic hotspots associated with psoriasis 2Researchers identify 4 genetic hotspots associated with psoriasis 3Hypertension and cholesterol medications present in water released into the St. Lawrence River 2
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... 2014 Rainbow Scientific, Inc. (RSI), ... recently opened an online store to add customer ... lines developed and manufactured by Biological Industries, Inc. ... Biological Industries’ Nutristem® serum-free, xeno-free reagents for human ... cell (hESC) culture. , The online store ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... the start of the military conflicts in Iraq and ... United States with traumatic brain injury caused by exposure ... improvised explosive devices, or IEDs. Symptoms of traumatic brain ... headaches and nausea, to more severe impairments in memory ... of Defense has recognized the critical importance and complexity ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... SAN DIEGO, Sept. 24 Neurocrine Biosciences,Inc. (Nasdaq: ... the UBS Global Life Sciences Conference. The live presentation,will ... Eastern Time,(ET) /5:30 a.m. Pacific Time (PT). The presentation ... Company,s website at, http://www.neurocrine.com If you are ...
... Available Only through Professionals, New Immuno-Skin Complex(TM) Targets ... to Fight the Causes of Skin Aging, EL ... his,credit including professional esthetic treatments utilizing AHA,s, and the,category ... of Medicine at UCLA, founder of Murad Inc. and ...
... Inc., a leading developer of advanced medical devices ... J. Daniel,Cole as the company,s new Chairman of ... partner with Spray Venture Partners, a venture,capital firm ... brings twenty years of medical device operational experience,having ...
Cached Biology Technology:Murad Boosts Skin Immunity With the New Murad(R) Professional Line 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2