Navigation Links
The egg makes sure that sperm don't get too old
Date:3/25/2009

In contrast to women, men are fertile throughout life, but research at the Sahlgrenska Academy, University of Gothenburg, Sweden, has now shown that a fertilising sperm can get help from the egg to rejuvenate. The result is an important step towards future stem cell therapy.

The risk of chromosomal abnormalities in the foetus is highly correlated to the age of the mother, but is nearly independent of the age of the father. One possible explanation is that egg cells have a unique ability to reset the age of a sperm.

"We are the first to show that egg cells have the ability to rejuvenate other cells, and this is an important result for future stem cell research", says Associate Professor Tomas Simonsson, who leads the research group at the Sahlgrenska Academy that has made this discovery.

Each time a cell divides, the genetic material at the ends of the chromosomes becomes shorter. The ends of the chromosomes, known as "telomeres", are important for the genetic stability of the cell and they act as a DNA clock that measures the age of the cell. The cell stops dividing and dies when the telomeres become too short.

The discovery that the egg cell can extend the telomeres of a fertilising sperm cell is important in the development of stem cell therapy. Stem cell therapy involves replacing the cell nucleus in unfertilised egg with a nucleus from a somatic cell that has come from a patient who needs a stem cell transplantation. As soon as the cell has divided a few times, it is possible to harvest stem cells that are then allowed to mature to the cell type that the recipient needs.

"The genetic stability of the transplanted cells has been a serious concern up until now, and it was feared that the lifetime of these cells would depend on the age of the cell nucleus that was transferred. Our results suggest that this is not the case", says Tomas Simonsson.


'/>"/>

Contact: Elin Lindstroem Claessen
elin.lindstrom@sahlgrenska.gu.se
46-708-294-303
University of Gothenburg
Source:Eurekalert

Page: 1

Related biology news :

1. Tobacco makes medicine
2. Liking sweets makes sense for kids
3. Oh baby, interventional radiology makes childbirth safer
4. Red wine vs. white? It makes no difference when it comes to breast-cancer risk
5. Mount Sinai Hospital researcher makes stem cell breakthrough
6. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
7. Rett Syndrome Research Trust advisor makes significant discovery
8. Tree lizard’s quick release escape system makes jumpers turn somersaults
9. Biophysical Reviews makes debut in 2009
10. Our unconscious brain makes the best decisions possible
11. Fly guy makes memory breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... published in Cancer Research shows SIRT6—a protein ... cancers—can promote the development of skin cancers by turning ... of sun-damaged skin cells. , Previously considered protective, SIRT6 ... sirtuins that help regulate genomic stability and prevent some ... repair DNA damage, which can lead to cancer. This ...
(Date:10/14/2014)... the house fly genome for the first time, revealing ... insect that thrives in pathogen-rich dung piles and garbage ... journal Genome Biology , will increase understanding of ... quickly adapt to resist insecticides, which could lead to ... carry and transmit more than 100 human and animal ...
(Date:10/14/2014)... Mount Sinai-led research team has discovered a new kind of ... a cell that lines liver blood vessels, according to a ... . The existence of such a cell type contradicts current ... embryo, and may hold clues to origins of, and future ... from a single cell into a complex being made up ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2House fly genome reveals expanded immune system 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3
... 19, 2012 A new study by scientists on ... in cell culture, a natural compound can virtually eliminate ... defines a novel class of HIV anti-viral drugs endowed ... and chronically infected cells. The HIV/AIDS pandemic continues ...
... , New Rochelle, NY, July 19, 2012To enable greater ... approaches such as co-firing of high percentages of biomass ... A comprehensive review of the strategies currently available and ... presented in I ndustrial Biotechnology , a peer-reviewed journal ...
... The Wyss Institute for Biologically Inspired Engineering at Harvard ... million contract (including option) from the Defense Advanced Research ... helps improve physical endurance for soldiers in the field. ... onset of fatigue, enabling soldiers to walk longer distances, ...
Cached Biology News:Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture 2Strategies to improve renewable energy feedstocks 2Harvard's Wyss Institute to develop smart suit that improves soldiers' physical endurance 2
(Date:10/22/2014)... Cranford, NJ (PRWEB) October 22, 2014 ... technologies and services – has been working with a ... Health and New Haven Farms Community Farming Collaborative to ... iPad-based ePRO solution. The study, which started in ... Wellness program that provides participants weekly exposure to and ...
(Date:10/22/2014)... SC (PRWEB) October 22, 2014 ... of its cardiovascular pharmacogenetics menu, which enables healthcare ... outcomes. With PCLS’s evidence-based results, healthcare providers ... and optimize their therapy, while minimizing risks for ... the U.S., according to the FDA [1] more ...
(Date:10/22/2014)... Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... next steps for its Oral Amphotericin B program.  ... in vitro work involving samples from ... plans to complete pre clinical studies and regulatory ... 1A clinical trial, utilizing approximately $700,000 of funding ...
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
Breaking Biology Technology:myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... difficult transfections when using the,complete control kit ... , We describe the vector pFB-ERV, an MMLV-based ... proteins RXR and VgEcR.,In stable cell lines infected ... induction ratios of greater than 200-fold are attainable ...
... One column purification of protein with native amino ... Wyborski * John C. Bauer * Barbara McGowan ... Systems, Inc. , Stratagene has improved the Affinity ... the pCAL-n-EK vector. This E. coli,cloning and expression ...
... highly specific digestion of purified,proteins or proteins in ... Claycomb * ChaoFeng Zheng * Denise Wyborski,* John ... Bernardino * Peter Vaillancourt ,Stratagene Cloning Systems, Inc. ... that cleaves at the carboxy terminus of its ...
Cached Biology Technology:pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 2pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 3pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 4pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 5pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 2Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 3Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 4Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 5Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 7Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 8Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 2Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 3Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini 4
... Genome-pULSe Kit delivers a novel procedure for ... labeling of whole genome DNA from small ... provide a quick and highly reproducible amplification ... consists of a REPLI-g Mini Kit module ...
... Introduction of a protein into cells permits ... signaling pathways, apoptotic pathways, and transcription factor-mediated ... studying the effects of a specific protein ... the protein directly into the cell. ProteoJuice ...
... ST-190-XY is an automated instrument with a ... in real-time using light or fluorescence microscopy. ... muscle, and fibroblast cells can be simulated ... X and Y axis of our strain ...
... Our Smart Solutions has now entered the ... (HCS) by partnering up with Cellomics, Inc. ... the integration of Beckman Coulter‘s automated solutions ... deeper biological information at the sub-cellular level. ...
Biology Products: