Navigation Links
The effect of catch-up growth by various diets and resveratrol intervention on bone status
Date:3/7/2012

-fat diet group were markedly higher than either the normal control or the re-feeding with high-fat diet group. The higher serum TNF-α level in the CUG by high-fat diet group along with a lower body weight may partially explain the decline in bone parameters compared with the high-fat diet group.

In the resveratrol intervention groups, bone parameters significantly increased. Furthermore, bone parameters were inversely related with serum TNF-α concentrations, but showed positive correlation with body weight. In conclusion, the study shows that CUG can partially reverse the deleterious effects of caloric restriction on bone health, especially in re-feeding with normal chow group. Moreover, resveratrol has protective effect on bone status during the period of CUG, but the exertion of this protective role depends on sufficient nutrition supply. Serum TNF-α levels and body weight also seem to play an important role in regulating bone parameters. Resveratrol has anti-inflammatory effects, increases bone formation but inhibits excessive weight gain. This can be used as a template for synthesizing new drugs, providing a large potential for treatment of overweight and osteoporosis groups.

Steven R. Goodman PhD, Editor in Chief of Experimental Biology and Medicine said "Wang and colleagues have demonstrated that re-feeding with a normal diet showed a larger improvement in bone mineral density than a high-fat diet. Resveratrol has also been demonstrated to have a protective effect on bone status during the period of catch up growth. As serum TNF-α levels and body weight also appear to play a role in regulating bone parameters this study may have important implications for the treatment of obesity and osteoporosis".


'/>"/>

Contact: Dr. Lu-Lu Chen
cheria_chen@126.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. More effective method of imaging proteins
2. Effects of environmental toxicants reach down through generations
3. Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments
4. Coral reef study traces indirect effects of overfishing
5. Create effective new global environmental agency, ministers urged
6. Study simulates effects of foot-and-mouth disease outbreak in Mexico
7. Anthrax-killing foam proves effective in meth lab cleanup
8. Time of year important in projections of climate change effects on ecosystems
9. System to deliver organ transplant drug -- without harmful side effects
10. Coastal storms have long-reaching effects, study says
11. Turtles mating habits protect against effects of climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Monash University Professor Steven Chown has been awarded ... Medal for Excellence in Antarctic Research. , SCAR, ... coordinates high quality international scientific research in the ... Antarctic region in the Earth system. The organisation ... Antarctic Treaty System, responsible for governing the region. ...
(Date:7/30/2014)... for spinal cord injury (SCI), traumatic brain injury (TBI) ... deal has been learned over the past 30 years ... that regulate axon growth, but this large body of ... Prof. Lemmon and his team from University of Miami ... causes, but a consensus is emerging that one contributing ...
(Date:7/30/2014)... , July 30, 2014 The Nano-Bio ... United States Air Force Research Laboratory (AFRL), has ... Binghamton University to develop electronics ... (HPM). The $425,000 project, with contributions from the ... i3 Electronics, Inc. ( Endicott, N.Y. ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3
... $50 million to a multi-institution collaborative headquartered at the ... cyberinfrastructure for the biological sciences. The renewal ... the Texas Advanced Computing Center (TACC) at the University ... New York, and University of North Carolina Wilmington (UNCW), ...
... Researchers have discovered why multiple myeloma, a difficult to cure ... effective treatment that can keep the disease at bay for ... colleagues at Princess Margaret Hospital in Toronto, researchers from Mayo ... in Phoenix were part of the team that conducted the ...
... NEW YORK , Sept. 18, 2013 ... research report is available in its catalogue: ... Global Biometrics Market ... the Market Grow Manifold,This study analyzes the ...
Cached Biology News:$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 2$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 3$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 4Research team uncovers root cause of multiple myeloma relapse 2Emerging Opportunities in Global Biometrics Market 2Emerging Opportunities in Global Biometrics Market 3Emerging Opportunities in Global Biometrics Market 4Emerging Opportunities in Global Biometrics Market 5
(Date:7/30/2014)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) today ... Outstanding Issues (LOI) from the European Medicines Agency,s Committee ... NB32 Marketing Authorization Application (MAA). NB32 (naltrexone sustained release ... being evaluated for weight loss. The key ... adequately addressed by the Company based in part on ...
(Date:7/30/2014)... , July 30, 2014  RXi ... a biotechnology company focused on discovering, developing ... medical needs using RNA-targeted technologies, today announced ... with RXI-109, for the reduction of recurrence ... surgery, has been initiated. Logo ...
(Date:7/30/2014)... 2014 Immunology Summit-2014 ... Principle Investigators, scientists in the field, which includes ... at Case Western Reserve University School of Medicine, ... on “The effects of recombinant human IL-6 ... metalloproteinase-9”. Arya Biragyn, a Senior investigator at National ...
(Date:7/29/2014)... The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
Breaking Biology Technology:Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4
... FRANCISCO , Jan. 13 Today, endpoint ( ... users to design and deploy clinical trial IRT systems in ... Leveraging a background of more than 12 years designing Integrated ... designed PULSE to balance speed of deployment with flawless quality. ...
... ROCHESTER, N.Y. , Jan. 12 After a decade of ... decelerated and may have even fallen when adjusted for inflation.  That is ... the American Medical Association .   , "The era of rapid expansion ... Ray Dorsey , M.D. , a neurologist at the ...
... , ... Institute announces twenty-four exhibitors to showcase new products at the 17th Molecular Medicine Tri-Conference, ... Molecular Medicine Tri-Conference is the predominant event on the west coast focused on integrating ... ...
Cached Biology Technology:endpoint Introduces First Fully Configurable IRT System 2Study: Era of Rapid Growth in Biomedical Research Over 2Study: Era of Rapid Growth in Biomedical Research Over 3Study: Era of Rapid Growth in Biomedical Research Over 4Study: Era of Rapid Growth in Biomedical Research Over 5Study: Era of Rapid Growth in Biomedical Research Over 6A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 2A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 3A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 4
Request Info...
Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
... siRNA service provides the premium quality siRNAs ... Custom siRNAs can be readily ordered online ... sequence, or by providing the sense and ... Silencer Validated and Silencer Pre-designed siRNAs, which ...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
Biology Products: