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The effect of catch-up growth by various diets and resveratrol intervention on bone status
Date:3/7/2012

-fat diet group were markedly higher than either the normal control or the re-feeding with high-fat diet group. The higher serum TNF-α level in the CUG by high-fat diet group along with a lower body weight may partially explain the decline in bone parameters compared with the high-fat diet group.

In the resveratrol intervention groups, bone parameters significantly increased. Furthermore, bone parameters were inversely related with serum TNF-α concentrations, but showed positive correlation with body weight. In conclusion, the study shows that CUG can partially reverse the deleterious effects of caloric restriction on bone health, especially in re-feeding with normal chow group. Moreover, resveratrol has protective effect on bone status during the period of CUG, but the exertion of this protective role depends on sufficient nutrition supply. Serum TNF-α levels and body weight also seem to play an important role in regulating bone parameters. Resveratrol has anti-inflammatory effects, increases bone formation but inhibits excessive weight gain. This can be used as a template for synthesizing new drugs, providing a large potential for treatment of overweight and osteoporosis groups.

Steven R. Goodman PhD, Editor in Chief of Experimental Biology and Medicine said "Wang and colleagues have demonstrated that re-feeding with a normal diet showed a larger improvement in bone mineral density than a high-fat diet. Resveratrol has also been demonstrated to have a protective effect on bone status during the period of catch up growth. As serum TNF-α levels and body weight also appear to play a role in regulating bone parameters this study may have important implications for the treatment of obesity and osteoporosis".


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Contact: Dr. Lu-Lu Chen
cheria_chen@126.com
Society for Experimental Biology and Medicine
Source:Eurekalert

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