Although many current studies focused on catch up growth (CUG) have described its high susceptibility to insulin resistance-related diseases very few have focused on the effect of CUG on bone metabolism, especially in adulthood. As diet is a controllable factor, the inﬂuence of re-feeding with different dietary patterns on bone parameters is important to study. Resveratrol has been attributed a number of beneficial effects in mammals including osteotrophic properties. In the March 2012 issue of Experimental Biology and Medicine Wang and colleagues describe the first study to describe the effects of CUG, with different diets, on bone status and the role of resveratrol in CUG models.
CUG can lead to insulin resistance and low-grade systemic inflammation occurs in insulin resistance syndrome. Tumor necrosis factor (TNF)-α is an important inﬂammatory cytokine, and Lange and Seriolo et al. indicated that anti-TNF alpha therapy may exert beneficial effects on bone metabolism, prevent structural bone damage and increase bone mineral density.
Dr. Wang said "Our results showed that food restriction induced a significant decrease in bone parameters. Eight-week CUG by normal chow demonstrated a greater degree of improvement in mineral density than a high-fat diet, and even returned to normal level." Dr. Wang also said, "In contrast, Mika C found that re-feeding for two years normalized bone formation activity in adolescent anorexia nervosa patients, but bone mineral density was still significantly lower than that of controls. Compared with neural anorexia, we found in this study the degree of impairment by four-week diet restriction on bone metabolism was relatively weaker, so that bone mineral density returned to normal level after re-feeding."
To better distinguish the effects of CUG by high-fat diet on bone status, these investigators set up a high-fat diet group. Their results showed that bone parameters in the high
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Society for Experimental Biology and Medicine