Navigation Links
The downside of microtubule stability
Date:6/15/2009

Stalled microtubules might be responsible for some cases of the neurological disorder Charcot-Marie-Tooth (CMT) disease, Tanabe and Takei report in the June 15, 2009 issue of the Journal of Cell Biology (www.jcb.org). A mutant protein makes the microtubules too stable to perform their jobs, the researchers find.

The mutations behind CMT disease slow nerve impulses, reduce their strength, or both. One of these mutations leads to production of faulty dynamin 2, a protein that is crucial for endocytosis but also latches onto microtubules. Tanabe and Takei investigated how defective dynamin 2 hampers cells.

Normal microtubules are continually extending and shrinking. But microtubules from cells that made the faulty version of dynamin 2 were abnormally stable, as measured by how many acetyl groups were attached to them. The researchers also found that blocking normal dynamin 2 with RNAi had the same effect as the mutation, confirming that one of dynamin 2's functions is to promote microtubule turnover.

Removing dynamin 2 shattered the Golgi complex, Tanabe and Takei discovered. Dynamic microtubules help construct the Golgi complex in two ways: they capture the vesicles that combine to form a mature Golgi complex; and they provide a track along which these vesicles can travel to their rendezvous point near the nucleus. By breaking up the Golgi apparatus and then watching the fragments reunite, the researchers found that dynamin 2 was essential for the capture step, not for transportation. Dynamin 2 also clings to microtubules of the mitotic spindle, and the team next wants to determine whether the protein regulates microtuble dynamics during the cell cycle.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Growing use of nanomaterials spurs research to investigate possible downsides
2. Temporary infidelity may contribute to the stability of ancient relationships
3. Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services
4. Making a point: Picoscale stability in a room-temperature AFM
5. Breast cancer genome shows evolution, instability of cancer
6. Seeking sustainability in a world of instability
7. Human RecQ helicases, homologous recombination and genomic instability
8. Predators and parasites may increase evolutionary stability
9. Great Plains historical stability vulnerable to future changes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The downside of microtubule stability
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... 11, 2017 , ... Disappearing forests and increased emissions are the main causes ... each year. Especially those living in larger cities are affected by air pollution related ... the most pollution-affected countries globally - decided to take action. , “I knew I ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
Breaking Biology Technology: