Navigation Links
The dietary supplement genistein can undermine breast cancer treatment
Date:9/23/2008

CHAMPAIGN, Ill. Women taking aromatase inhibitors to treat breast cancer or prevent its recurrence should think twice before also taking a soy-based dietary supplement, researchers report.

Genistein, a soy isoflavone that mimics the effects of estrogen in the body, can negate the effectiveness of aromatase inhibitors, which are designed to reduce the levels of estrogens that can promote tumor growth in some types of breast cancer.

The new study, which included researchers from the University of Illinois, Virginia Polytechnic and State University and the National Center for Toxicological Research, appears in the journal Carcinogenesis.

Aromatase inhibitors are a mainstay of breast cancer treatment in post-menopausal women. These drugs work by interfering with the enzyme aromatase, which catalyzes a crucial step in converting precursor molecules to estradiol, the main estrogen in the body.

About two-thirds of all cases of breast cancer diagnosed in the U.S. are estrogen dependent or estrogen sensitive, which means that the tumors grow more rapidly in the presence of estrogen.

Most women diagnosed with breast cancer are post-menopausal, so their ovaries are no longer producing normal levels of estrogen. Other tissues, however, produce a steroid hormone, androstenedione (AD), which with the help of aromatases is converted to testosterone and estrogens. The estrogens produced from AD can stimulate the growth of some types of breast cancer tumors.

The researchers conducted several trials in a mouse model of estrogen-dependent post-menopausal breast cancer. First, they gave the mice AD, which was converted to estrogen and created a high estrogen environment.

This helped the researchers determine the maximum growth rate of the breast cancer tumors.

Next, they added Letrozole, an aromatase inhibitor widely prescribed to post-menopausal women with estrogen-dependent breast cancer. Th
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers uncover details about how dietary restriction slows down aging
2. Market testing of dietary supplements and drugs underscores value of USPs public health programs
3. Changing the global dietary environment
4. Dietary calcium could possibly prevent the spread of breast cancer to bone
5. UF scientists reveal how dietary restriction cleans cells
6. L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today
7. Researchers identify cancer preventive properties in common vitamin supplement
8. A nutritional supplement could improve the clinical situation of ICU patients
9. People with diabetes may have all natural citrus supplement
10. Wellmune WGP supplementation alleviates
11. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The dietary supplement genistein can undermine breast cancer treatment
(Date:4/17/2014)... 2014The development of stem cell therapies to cure a ... stem cell populations based on cell surface markers. Researchers ... marker that is highly expressed in a type of ... they describe in an article in BioResearch Open ... Inc., publishers. The article is available free on the ...
(Date:4/17/2014)... suggests that fish consumption advisories for expecting mothers ... contaminants like persistent organic pollutants (POPs). , ... including University of Toronto Scarborough PhD student Matt ... different levels of environmental contamination, a mother,s compliance ... the body influenced exposure in her children. , ...
(Date:4/17/2014)... credit-card-sized anthrax detection cartridge developed at Sandia National Laboratories ... safer, easier, faster and cheaper. , Bacillus ... found in soils all over the world and can ... and animals. The bacteria can survive in harsh conditions ... may occur through skin contact, inhalation of spores ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... are part of an international team that has used DNA ... history of North America,s woolly mammoths and ancient horses. ... professor Duane Froese and his colleagues counters an important extinction ... analysis concluded that more than half of the large mammals ...
... FAIRBANKS, AlaskaScientists have identified a novel antifreeze molecule ... below minus 100 degrees Fahrenheit. Unlike all previously described ... xylomannan, has little or no protein. It is composed ... exist in new places within the cells of organisms. ...
... or for Tasmanian devils biting each other on ... to extinction through the transmission of a protozoan parasite. ... detective work, of David Varricchio and colleagues published in PLoS ... was to blame for the diseased jaw bones seen in ...
Cached Biology News:Scientists isolate new antifreeze molecule in Alaska beetle 2
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... (ABI) (OTCBB: AMAR) today provided an update on company activities. ... Nearing CompletionABI,s oral interferon research continues. Results from a Phase ... relapse in hepatitis C patients are expected in the first ... in combination with Tamiflu, for the treatment of influenza infection ...
... VEGA BIOFUELS, INC. (Pink Sheets: VGPR ) provides ... In my last Update, I mentioned that we were working ... has caused problems for our shareholders that use Penson and Alpine ... been working to resolve this matter. We have been ...
... HONG KONG, Oct. 14, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood ... the first and largest cord blood banking operator in China, today ... shareholders at its Hong Kong office at 48/F, Bank of China ... Kong Time on December 19, 2011 (8:00 a.m. U.S. Eastern Time ...
Cached Biology Technology:Amarillo Biosciences Issues Corporate Update 2Vega Biofuels Provides Update to Shareholders 2China Cord Blood Corporation to Hold Annual General Meeting in Hong Kong on December 19, 2011 2
... High pH, Concentrated x 10 This ... target retrievel prior to immunohistochemical staining procedures. ... tissue sections mounted on glass slides. For ... 9.9, is especially effective. It should be ...
... off-white solid. Increases the expression of glutathione peroxidase. ... H 2 O. Unstable in aqueous solutions; ... CAS 3211-76-5, M.W. 196.1. References: Merck ... Junod, A.F. 1995. Biochem. J. ...
... UN-SCAN-IT gel Software converts any scanner into ... numerous options and features, the basic operation ... JPEG, PCX, BMP, etc.) into pixel density ... steps. Turn your scanner ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: