Navigation Links
The dark path to antisocial personality disorder
Date:2/7/2012

Philadelphia, PA, February 7, 2012 With no lab tests to guide the clinician, psychiatric diagnostics is challenging and controversial. Antisocial personality disorder is defined as "a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood," according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) of the American Psychiatric Association.

DSM-IV provides formal diagnostic criteria for every psychiatric disorder. This process may be guided by rating scales that measure the traits and features associated with a personality disorder. But, until now, no one has studied the dimensional structure associated with the DSM antisocial personality disorder criteria.

Dr. Kenneth Kendler of Virginia Commonwealth University and colleagues examined questionnaire and genetic data from adult twins. They found that the DSM-IV criteria do not reflect a single dimension of liability but rather are influenced by two dimensions of genetic risk reflecting aggressive-disregard and disinhibition.

"When psychiatrists, as clinicians or researchers, think about our psychiatric disorders, we tend to think of them as one thing one kind of disorder a reflection of one underlying dimension of liability," said Dr. Kendler. "This is also true of genetics researchers. We tend to want to identify and then detect 'the' risk genes underlying disorder X or Y."

Kendler added, "What is most interesting about the results of this paper is that they falsify this inherent and rather deeply held assumption. Genetic risk factors for antisocial personality disorder are not one thing. Rather, the disorder, as conceptualized by DSM-IV, reflects two distinct genetic dimensions of risk."

"The findings from this study make sense. The distinction between the two sets of heritable traits contributing to antisocial personality disorder, aggressive-disregard and disinhibition, highlights the complexity of unraveling the genes contributing to this personality style. We now have some puzzle pieces, but we have a long way to go to fit these pieces together," commented Dr. John Krystal, editor of Biological Psychiatry.


'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related biology news :

1. Biography captures Sydney Brenners unflagging scientific curiosity and lively personality
2. Personality predicts political preferences
3. Understanding a cells split personality aids synthetic circuits
4. Cells split personality is a major discovery into neurological diseases
5. Sugar, spice and puppy dog tails: Developing sex-typed personality traits and interests
6. MU researcher identifies possible genetic causes of borderline personality disorder
7. New test spots early signs of inherited metabolic disorders
8. Severe congenital disorder successfully treated in a mouse model for the first time
9. Controlled disorder -- scientists find way to form random molecular patterns
10. Picower: Schizophrenia gene associated with psychiatric disorders and brain development
11. Diagnoses of autism spectrum disorders vary widely across clinics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... , ... May 23, 2016 , ... ... organization focused on molecular nanotechnology, announced the winners for the 2015 Foresight Institute ... Richard Feynman, are given in two categories, one for experiment and the other ...
(Date:5/20/2016)... ... ... Kablooe Design, a leading provider of product design and development services to medical ... “We have worked hard to build long-term relationships,” says President and CEO, Tom KraMer. ... serving their product design and development needs through the years.” , Kablooe has earned ...
(Date:5/19/2016)... ... 19, 2016 , ... Anton Paar USA, located in Ashland, Virginia is pleased ... The new structure adds a third office building to the current facilities. , ... acres of land, along with office space adjacent to the previous main building. Through ...
(Date:5/19/2016)... Kansas City, KS (PRWEB) , ... May 19, ... ... and biomarker contract research organization (CRO) has welcomed Abu Siddiqui as Director, Large ... designing, managing and executing biologics, vaccine and translational biomarker discovery studies for preclinical ...
Breaking Biology Technology: