Navigation Links
The construction of heart modelling leads path to new therapies
Date:1/10/2008

Heart disease is still a major killer, especially in the western world, but new therapies based on stem cells and other techniques could now be imminent. Progress is being held back however by the difficulty testing new therapies on human heart tissue, with animal models being only of limited value owing to differences in structure and activity. The only solution in the absence of real human models is to create computerised in-silico models that simulate the real heart and enable possible drugs and therapies to be tested without risk to people. Although this is still some way off becoming a reality, substantial progress has been made, and the next steps were plotted at a major workshop held recently by the European Science Foundation (ESF).

The workshop highlighted how recent progress in imaging technologies was helping heart modellers overcome the big dilemma they have faced up till now actually proving that the models really are an accurate representation of the real human heart. This has been the big catch 22 of heart modelling, that in order to create a realistic model, you need accurate and extensive data from real hearts for calibration. Validation of the models is very important, and was raised at the workshop, said Blanca Rodriguez, scientific coordinator of the ESF workshop, and senior cardiac researcher at Oxford University, Europes leading centre for cardiac modelling. One of the problems has been that it is much easier to get experimental data from animals than humans.

Such animal data can help calibrate some aspects of the models, but only data from human hearts can fine tune them to the point at which they can actually make useful predictions and test therapies. Fortunately such data is now becoming available as a result of dramatic progress in imaging techniques that can observe cardiac activity externally without need for invasive probes. We are now getting data at very high resolutions, and that allows us to model things in
'/>"/>

Contact: Blanca Rodriguez
Blanca.Rodriguez@comlab.ox.ac.uk
44-018-652-73838
European Science Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Texel paleothermometer for climate reconstruction perfected
2. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
3. Researchers take first steps towards spinal cord reconstruction following injury
4. Abnormal fat metabolism underlies heart problems in diabetic patients
5. High blood pressure, low energy -- a recipe for heart failure
6. Human derived stem cells can repair rat hearts damaged by heart attack
7. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
8. Heart of Herschel to be presented to media
9. Minimally invasive heart surgery research wins NIH award
10. A step toward tissue-engineered heart structures for children
11. Research explains link between cholesterol and heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Europe,s ... European Patent Office to present a video retrospective of the most ... featured: Christofer Toumazou and Sophie Wilson   ... of the Award   Starting on 22 January 2015 ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time ... sets a higher standard for collecting attendance and labor data ... plug-and-play installation, touch screen interface and seamless connection to cloud-based ... collection solution for the small to mid-size employer. ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... 2009, six leading ecosystem researchers will share with lawmakers key ... This science briefing is part of the annual Association ... Cities around the nation are bracing for the impacts ... states to drought in the west, water will be at ...
... relief and a good cleansing for millions of Americans, ... pathogenic bacteria, according to a surprising new University of ... high-tech instruments and lab methods to analyze roughly 50 ... New York City, Chicago and Denver. They concluded ...
... of The 2009 Lasker Awards, announced today, represent the ... to a revolutionary cancer treatment and the tremendous promise ... portend a potential $700 million global market for new ... Genetic Engineering & Biotechnology News (GEN, www.genengnews.com ...
Cached Biology News:Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 2Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 3Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 42009 Lasker Awards recognize promise of stem cells -- global market could top $700 million 2
(Date:1/23/2015)... 23, 2015 Portal Solutions , a ... on Microsoft Office 365 and SharePoint platforms , today ... program for being one of the region’s fastest-growing mid-sized companies ... growth. , “To be recognized a second year in ...
(Date:1/22/2015)... 2015 Shimadzu Scientific Instruments today ... UV-visible spectrophotometer. Offering wavelength scanning from 190 to ... for applications in a variety of industries, including ... user-friendly UV-1280 enables intuitive operation, while the enhanced ...
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2
... Doyle gathered over 100 executives and leaders of ... to preview his new economic growth package. These ... leadership, The Wisconsin Technology Council as well many ... capitalists. The message they heard from governor was ...
... Patients Compensation Fund could be illegal , ,While ... support yesterday for Gov. Jim Doyles Grow Wisconsin program, ... support, but takes issue with the provisions for the ... criticism for Doyles proposed use of funds from the ...
... Its Saturday night. Your 4 year old has stomach pains, and ... all sorts of personal medical information including her medical history and ... and you try to remember if you told the person at ... two as the triage nurse does not see bleeding or an ...
Cached Biology Technology:Governor Gathers Biotech Leaders at his Residence 2Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4Childrens Medical Hospital of Wisconsin Goes Digital 2Childrens Medical Hospital of Wisconsin Goes Digital 3Childrens Medical Hospital of Wisconsin Goes Digital 4