Navigation Links
The connection between a cell's cytoskeleton and its surface receptors
Date:3/6/2011

WASHINGTON, D.C. (March 6, 2011) -- New findings from researchers at Harvard Medical School in Boston and the Hospital for Sick Children in Toronto may shed light on the mechanisms that regulate the organization of receptors on the cell surface, a critical aspect of cell signaling not well understood at this time.

The group reports on their use of the macrophage protein CD36, a clustering-responsive class B scavenger receptor, as a model for studying the processes governing receptor clustering and organization. The protein is involved in a number of cellular and physiological functions that range from lipid metabolism to immunity, but it is unknown how the CD36 protein is organized in the cell (as monomers or as oligomers) and how that organization leads to its biological functions.

The researchers employed a combination of powerful tools: quantitative live-cell single-molecule imaging and biochemical/pharmacological approaches to study the dynamics, oligomerization and signaling of CD36 in primary human macrophages.

The group reports that movement of CD36 in the macrophage plasma membrane is regulated by the sub-membranous actin meshwork and by microtubules, demonstrating that these cytoskeletal components might play a critical role in receptor function, in general.

In terms of the impact of this research, lead researcher Khuloud Jaqaman says: "In the long run, establishing the relationship between receptor organization and cell signaling might aid in the development of drugs since receptors on the cell surface are the most accessible to pharmacological manipulation."


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert  

Page: 1

Related biology news :

1. Immune molecule regulates brain connections
2. Connection between light at night and cancer revealed in additional study
3. Connection between light at night (LAN) and cancer revealed in additional study
4. Brain connections break down as we age
5. Calcium connections: Basic pathway for maintaining cells fuel stores
6. Searching for causes of neural disconnection in schizophrenia
7. Connection elucidated between obesity, salt sensitivity and high blood pressure
8. Brain connections for stress -- lessons from the worm
9. Impaired brain connections traced to schizophrenia mutation
10. Lifelong memories linked to stable nerve connections
11. The food-energy cellular connection revealed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The connection between a cell's cytoskeleton and its surface receptors
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... Charlotte, NC (PRWEB) , ... August 15, 2017 , ... ... in 2017, celebrating 10 years of successes helping medical technology companies and inventors develop ... company to a renowned full-service national engineering firm with a portfolio of clients in ...
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon ... exhibitions for analytical and scientific instruments. This year’s symposium, organized by the Pittcon ... Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, ...
(Date:8/15/2017)... Wisconsin (PRWEB) , ... August 15, 2017 , ... ... a new family of 6” modular downlights designed to stay tightly sealed and ... including areas where damp and wet location listings just aren't enough, such as: ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... and is threatened by various biotic and abiotic factors. During this educational webinar, ... history of coffee, as well as gain a better understanding of how genomics ...
Breaking Biology Technology: