Navigation Links
The connection between a cell's cytoskeleton and its surface receptors
Date:3/6/2011

WASHINGTON, D.C. (March 6, 2011) -- New findings from researchers at Harvard Medical School in Boston and the Hospital for Sick Children in Toronto may shed light on the mechanisms that regulate the organization of receptors on the cell surface, a critical aspect of cell signaling not well understood at this time.

The group reports on their use of the macrophage protein CD36, a clustering-responsive class B scavenger receptor, as a model for studying the processes governing receptor clustering and organization. The protein is involved in a number of cellular and physiological functions that range from lipid metabolism to immunity, but it is unknown how the CD36 protein is organized in the cell (as monomers or as oligomers) and how that organization leads to its biological functions.

The researchers employed a combination of powerful tools: quantitative live-cell single-molecule imaging and biochemical/pharmacological approaches to study the dynamics, oligomerization and signaling of CD36 in primary human macrophages.

The group reports that movement of CD36 in the macrophage plasma membrane is regulated by the sub-membranous actin meshwork and by microtubules, demonstrating that these cytoskeletal components might play a critical role in receptor function, in general.

In terms of the impact of this research, lead researcher Khuloud Jaqaman says: "In the long run, establishing the relationship between receptor organization and cell signaling might aid in the development of drugs since receptors on the cell surface are the most accessible to pharmacological manipulation."


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert  

Page: 1

Related biology news :

1. Immune molecule regulates brain connections
2. Connection between light at night and cancer revealed in additional study
3. Connection between light at night (LAN) and cancer revealed in additional study
4. Brain connections break down as we age
5. Calcium connections: Basic pathway for maintaining cells fuel stores
6. Searching for causes of neural disconnection in schizophrenia
7. Connection elucidated between obesity, salt sensitivity and high blood pressure
8. Brain connections for stress -- lessons from the worm
9. Impaired brain connections traced to schizophrenia mutation
10. Lifelong memories linked to stable nerve connections
11. The food-energy cellular connection revealed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The connection between a cell's cytoskeleton and its surface receptors
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... Translational Genomics Research Institute (TGen) is presenting two key studies, ... Cancer, July 3-7 in Amsterdam. One study, presented July ... effectiveness of the most common combination chemotherapy given to patients ... today, July 7, suggests that combination drug therapy may be ...
... boy bands of Americathere,s a new group in town. ... San Diego, California, entered The Christopher Columbus Awards Competition, ... challenges middle-school students to identify a community problem and ... from the popular group the Backstreet Boys, the students ...
... Researchers at the John Theurer Cancer Center recently published a ... stem cell transplants. Scott Rowley, M.D., Chief, Blood & Marrow ... Hackensack University Medical Center contributed to the study which was ... was published in the Journal of Consulting and Clinical ...
Cached Biology News:TGen presents lung cancer studies at Amsterdam conference 2Middle-school students educate community on proper computer posture 2John Theurer Cancer Center BMT researchers highlight the importance of social support 2
(Date:11/21/2014)... 2014 The California Healthcare ... organization representing leading California academic institutions, biotechnology, medical ... US today released a report revealing that ... growth. The trend shows a 4 percent increase ... Biomedical Industry Report indicates that, while biopharmaceutical ...
(Date:11/21/2014)... 2014 Why did Stephen Hawking become ... so instantly recognizable? Why have they become icons to ... author Hilton Ratcliffe seeks out the answers to those ... to do with science. In " Stephen Hawking Smoked ... 21, 2014), Ratcliffe puts it plainly: , “It ...
(Date:11/21/2014)... /CNW/ - Aequus Pharmaceuticals Inc. (the "Company" or ... closed a brokered private placement offering (the "Brokered ... Cormark Securities Inc. and Clarus Securities Inc. acted ... a syndicate of agents that also included Wolverton ... "Agents"). Concurrently with the Brokered Offering, the Company ...
(Date:11/18/2014)... Sarasota, FL (PRWEB) November 17, 2014 ... novel point-of-care diagnostic tests – today announces its ... Control and Prevention’s (CDC) Get Smart About Antibiotics ... Antibiotics Week is a national campaign designed to ... local health departments, and non-profit and for-profit partners ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
... TOKYO, Japan, October 14 Sosei ... company,today announces the assignment of the drug discovery ... UK biotechnology company and subsidiary of,PepTcell Limited. These ... were shown by Sosei to have pronounced anti-inflammatory ...
... 13 SpectraScience, Inc. (OTC Bulletin Board: SCIE), a ... it has engaged Bielderman BVBA, an experienced European contract ... Barrett,s esophageal cancer application under trial at certain European ... Company,s application to the Food and Drug Administration ("FDA") ...
... CPHD ) today announced that it will report financial ... Wednesday, October 28, 2009, after the close of the market. ... p.m. Pacific Time on Wednesday, October 28, 2009, to discuss ... Cepheid,s website at www.cepheid.com/investors at least ...
Cached Biology Technology:Sosei Announces Deal With UK Biotech Company 2SpectraScience Engages European Contract Research Organization to Manage Clinical Trials 2SpectraScience Engages European Contract Research Organization to Manage Clinical Trials 3Cepheid Schedules 2009 Third Quarter Financial Results Announcement and Webcast 2
... by Stoelting, selects single cells, or clusters, ... time at all, a single cell can ... cell is collected into the pipette, and ... a microtiter plate. Quixells unique aspiration and ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Viruses microRNA Microarray contains ...
... At the forefront of Agilent analytical solutions ... local area networking (LAN) allows you to ... fast and informed decision making. Just as ... all the flexibility and performance needed for ...
The novel and unique HCTplus delivers unmatched information-rich data-dependent LC/MSn data for todays challenge in proteomics and metabonomics work....
Biology Products: