Navigation Links
The challenges of avian influenza virus: Mechanism, epidemiology and control
Date:5/22/2009

us some tantalizing hope for the control of virus infection. Nucleoprotein (NP) is an important structural protein of influenza virus, being the key component of the ribonucleoprotein complex. The structure of NP is revisited by Andy NG, Jia-Huai WANG and Pang-Chui SHAW from Dana-Farber Cancer Institute and the Chinese University of Hong Kong. Correlations are made between the sequence conservation and the atomic structure. This provides the basis for identifying structurally and functionally important regions for inhibitor design. Crystal structures of some parts of the polymerase complex, PA alone or PA with part of PB1, have been solved. Zihe RAO, Yingfang LIU and colleagues from Institute of Biophysics, CAS, Tsinghua University and Nankai University, provide an overview of the structure and potential target for the new drug design. For a long time the drug target for influenza viruses was basically limited to two proteins, hemagglutinin (HA) and neuraminidase (NA). Hopefully, the basic findings on nucleoprotein and polymerase will lead to some new drug leads.

Clinically the human cases of H5N1 infection manifest some ARDS (acute respiratory distress syndrome) symptoms, similar to SARS infection. Therefore unraveling the molecular pathogenesis mechanism will help save life. Chengyu JIANG, from Peking Union Medical College, Chinese Academy of Medical Sciences, who has long been involved in the study of molecular pathogenesis of SARS, describes our current understanding of the molecular pathogenesis of H5N1 in human infection and presents their recent work on the clathrin-dependent endocytosis of H5N1 influenza virus.

H5N1 virus research is a scientifically fascinating field and a much-needed field for life-saving. In the future we ought to know why and how H5N1 virus expands its host range. Compared to SARS, H5N1 is more complicated. Is there any chance human beings will be in a position to conquer this devastating virus? The understanding of H5N
'/>"/>

Contact: Li Jiyuan
ljy@scichina.org
86-106-401-5399
Science in China Press
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. SRI International receives $100,000 Grand Challenges Explorations grant
2. Major international study challenges notions of how genes are controlled in mammals
3. Climate change: Global risks, challenges and decisions
4. Y chromosome and surname study challenges infidelity myth
5. Experts discuss challenges in integrative approaches to science
6. First-ever socioeconomic study on coral reefs points to challenges of coastal resource management
7. Siblings of mentally disabled face own lifelong challenges, according to researchers
8. Research challenges conventional notions about salmon survival
9. Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability
10. Meeting the challenges of teaching agriculture
11. New research challenges long-held assumptions of flightless bird evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... released today by the National Academy of Sciences, ... and strategies for the program and will guide ... years (2015-2020). In addition, the program announced ... in 2015, will include exploratory grants, early-career research ... $500 million, 30-year program to be run by ...
(Date:9/15/2014)... in the oceans, there must be enough dissolved ... extreme oxygen-starvation produces "dead zones" that decimate marine ... oxygen levels decline, energy is increasingly diverted away ... in impacts on the ecology and biogeochemistry of ... oxygen minimum zones (OMZs) have expanded due to ...
(Date:9/15/2014)... who transplanted combinations of wild, domesticated, and ... to new environments found that within 5 ... foreign genes from wild populations that hybridized ... Applications study provides evidence that natural ... that hybridized populations experience as a result ...
Breaking Biology News(10 mins):NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... undergo surgery for breast cancer followed by radiation ... be corrected through reconstructive surgery. Researchers at the ... bioengineers at Carnegie Mellon University, have developed a ... as an artificial tissue filler after surgery and ...
... Researchers at the McKusick-Nathans Institute of Genetic Medicine at ... way of analyzing what many have termed "junk" DNA ... they have found that these control regions from different ... , The study will be published online at Science ...
... system response to foreign DNA, suggesting that DNA viruses ... School of Medicine researchers report this week in Immunity. ... be used to detect invasive bacteria in addition to ... in the Section of Immunobiology and lead author of ...
Cached Biology News:Chemotherapy gel may fight breast cancer and reduce breast deformity 2Junk DNA may not be so junky after all 2Junk DNA may not be so junky after all 3Immune system response to viral DNA is unique 2
(Date:9/13/2014)... Phoenixville, PA (PRWEB) September 13, 2014 ... medical device innovations, is proud to announce the successful ... Health Network bariatric surgeons Leonardo Claros, MD, FACS, FAMBS, ... ViSiGi 3Dâ„¢ Sleeve Gastrectomy Calibration System. , This ... a postgraduate course of more than four hundred surgeons ...
(Date:9/12/2014)... 12, 2014 Advancing the front ... of chemical and biological threats is the mission ... Polytechnic Institute (WPI) and the Georgian National Academy ... for Peace and Security Programme of the North ... Advanced Research Workshop series, the event is titled ...
(Date:9/12/2014)... 12, 2014 On Thursday, September 11, ... Dow Jones Industrial Average finished the day 0.12% lower at ... The gains were broad based as seven out of ten ... Care Sector Index ended the day at 741.83, down 0.33%, ... month. Investor-Edge has initiated coverage on the following equities: Exelixis ...
(Date:9/11/2014)... cells (hiPSCs), researchers have gained new insight into ... patterns of neuronal signaling associated with this disease. ... the hiPSCs of healthy individuals and of patients ... stem cells to release neurotransmitters, such as dopamine, ... linked to various disorders. By discovering a simple ...
Breaking Biology Technology:Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Worcester Polytechnic Institute to Lead Scientific Workshop on Nanoscale Defenses for Biological and Chemical Threats 2Worcester Polytechnic Institute to Lead Scientific Workshop on Nanoscale Defenses for Biological and Chemical Threats 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5Stem cells help researchers understand how schizophrenic brains function 2
... /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: CHBT) ... in the manufacture,research, development, marketing and distribution ... a new bilingual corporate Web site under,the ... The new Web site was created ...
... of tightly packed nanostructures that resemble tiny nails, University ... have created a material that can repel almost any ... liquid on the surface slips past the heads of ... the surface completely. , The new material, which was ...
... Mass., Jan. 29 Thermo Fisher,Scientific Inc. (NYSE: ... it will present at the 2008 Merrill Lynch Global ... Grand Hyatt,Hotel in New York City. The company will ... Marijn E. Dekkers, president and chief executive officer ...
Cached Biology Technology:China-Biotics, Inc. Launches English / Chinese Corporate and Investor Relations Web Site 2Thermo Fisher Scientific to Present at the 2008 Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference 2
... Protein A and Protein G bind specifically ... Protein A and Protein G conjugates are ... immunoglobulins (antibodies) and immunoglobulin subtypes from serum, ... other biological fluids. These reagents are also ...
... The SYS203 is a complete, ... measurement in small samples, as is ... system is designed around Instechs miniature ... of an inch in diameter (3.2 ...
... family of human cullin genes (CUL-1, -2, -3, -4a, ... gene. Cullin-3 is proposed to be a part of ... cyclin E and targets it for ubiquitination, which leads ... activator of cdk2, which leads the cell to S ...
... MetaVue Imaging System is the cost-effective solution ... commands tailored to common research imaging tasks, ... analysis and simple image analysis. Compatibility ... library means that MetaVue has the power ...
Biology Products: