First we invite two prominent scientists, Yuelong SHU and Paul CHAN, from China CDC and the Chinese University of Hong Kong respectively to overview the situation of human infection of H5N1 in mainland China and the experience in Hong Kong. They summarize the frontline epidemiological, clinical and virological characteristics of human avian influenza virus infections based on the national surveillance system in mainland China and give a chronological and archival description of the events in Hong Kong. These accounts would greatly be appreciated for the future preparedness of possible pandemics. From the current human reported H5N1 virus infection cases, most of the patients could trace back with contacts of birds (chicken or ducks) though there were some reports with evidence of limited human-to-human transmission. Therefore domestic or wild bird infection control is the key for the H5N1 human infection. Hualan CHEN from Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, discusses the situation of animal infection and the control in China.
As we know more and more species, especially some mammalian species such as cats and tigers, are found victims or carriers of H5N1, the expansion of the host range and interspecies transmission of H5N1 virus is worrisome. The mechanism underlying this change is elusive and scientists are working together to tackle this problem from our understanding of the virus itself and the host factors affecting this change. George F. GAO, Frank LIU and colleagues from CAS Key Laboratory of Pathogenic Microbiology and Immunology review our current knowledge of the interspecies transmission and host factors involved: from virus receptor usage to host proteins interacting with the virus or virus components.
Basic research always gives
|Contact: Li Jiyuan|
Science in China Press