Navigation Links
The cellular intricacies of cystic fibrosis
Date:9/19/2011

Bethesda, Md. (Sept. 19, 2011) When researchers discovered the primary genetic defect that causes cystic fibrosis (CF) back in 1989, they opened up a new realm of research into treatment and a cure for the disease. Since then, scientists have been able to clone the defective gene and study its effects in animals. Now researchers at the University of North Carolina at Chapel Hill have developed a technique for observing the defects at work in human tissue donated by patients with CF.

This technique has yielded an extraordinary view of the cellular intricacies of CF, which Martina Gentzsch, assistant professor of cell and developmental biology, will discuss at the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 in Pacific Grove, Calif. The meeting is sponsored by the American Physiological Society. Her poster presentation is entitled, "The Cystic Fibrosis Transmembrane Conductance Regulator Inhibits Proteolytic Stimulation of ENaC."

Ion Transport Processes in CF

Cystic fibrosis is caused by a mutation in the gene that encodes a protein called cystic fibrosis transmembrane conductance regulator (CFTR), which functions as a chloride channel at the surface of airways and moves chloride out of the cells. CFTR also regulates another protein called epithelial sodium channel (ENaC), which is responsible for transporting sodium into cells. Thus far, scientists have been able to establish that when the CFTR mutation is present, ENaC becomes overactive and causes the cells in the lungs to absorb too much sodium. Water follows the sodium from the cells' surfaces into the cells, and as a result, the airways become dry and mucous becomes thick and sticky, leading to infections in the lungs.

To observe how CFTR regulates ENaC, Dr. Gentzsch and her team took cells from healthy lung tissue and CF lung tissue and maintained them in a liquid medium. The cells' surface
'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cellular metabolism self-adapts to protect against free radicals
2. New cellular surprise may help scientists better understand human mitochondrial diseases
3. Cellular laser microsurgery illuminates research in vertebrate biology
4. Cellular stress can induce yeast to promote prion formation
5. Researchers provide means of monitoring cellular interactions
6. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
7. How muscle develops: A dance of cellular skeletons
8. Harvard scientists see the early cellular cause of dry eye disease for the first time
9. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
10. WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
11. Extracting cellular engines may aid in understanding mitochondrial diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... from McGill University and the Quebec government have ... Canadian Journal of Fisheries and Aquatic Sciences ... household cleansers, or industrial cleansers, to which they ... small size and buoyancy, they may readily pass ... global contaminant in the world,s oceans, but have ...
(Date:9/18/2014)... No matter how many times it,s demonstrated, ... communicating creatures. , But by using a ... radically alter their behavior to suit their population. ... them are present, and act accordingly. , Once ... it may change from innocuous to pathogenic, or ...
(Date:9/18/2014)... and creatively manipulate spoken language is unique to humans. ... million years of human evolution to make this possible ... gene we now have," says Wolfgang Enard, Professor of ... to understand the molecular biological basis of language Enard ... of his latest study, undertaken in collaboration with scientists ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... 2011 Neurotechnology , a provider of ... of MegaMatcher Accelerator 4.0 , the latest ... solution for high-volume, high-speed fingerprint and iris identification. ... enhanced fault tolerance and a new matching algorithm ...
... the Hawai,i Institute of Marine Biology (HIMB) have developed ... part of a hybrid web application titled GeoSymbio ... on symbiotic zooxanthellae called Symbiodinium which are ... other marine organisms like anemones, jellyfish, and corals. ...
... University of Maryland School of Medicine researchers have uncovered ... understanding cardiac arrhythmia and other heart muscle problems. Understanding ... open the door to new treatments. The study, published ... electrical impulses that coordinate contraction in heart and skeletal ...
Cached Biology News:Neurotechnology Releases MegaMatcher Accelerator 4.0 for National-scale Fingerprint and Iris Biometric Identification 2Neurotechnology Releases MegaMatcher Accelerator 4.0 for National-scale Fingerprint and Iris Biometric Identification 3Neurotechnology Releases MegaMatcher Accelerator 4.0 for National-scale Fingerprint and Iris Biometric Identification 4An online global map of coral and zooxanthellae data for climate change study is released 2An online global map of coral and zooxanthellae data for climate change study is released 3UM School of Medicine finds new pathway critical to heart arrhythmia 2UM School of Medicine finds new pathway critical to heart arrhythmia 3
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... addition of the "Global N-acetylcysteine Industry Report ... The Global N-acetylcysteine Industry Report 2014 is ... state of the global N-acetylcysteine industry. ... industry including definitions, classifications, applications and industry chain ...
(Date:9/18/2014)... TX (PRWEB) September 18, 2014 ... a FM-4910 listed material, to stay competitive in ... These high-performance materials ultimately impact product quality ... President and owner. , Established in 1980 in ... strong as many fabricators have left the business. ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... Sept. 18, 2014   Sigma-Aldrich Corporation ... has entered into a new gene editing partnership ... Vector Core. Under the partnership, Sigma-Aldrich will provide ... design consultation, and dedicated gene editing bioinformaticians. ... editing-based research at the U-M Medical School. One ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Merck Animal Health to market Neogen's dairy genomic program 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4
... 2011 Quest Diagnostics Incorporated (NYSE: DGX ) ... process of identifying a successor to Surya N. Mohapatra, Ph.D., ... has formed a search committee, engaged a leading executive recruitment ... Dr. Mohapatra has agreed to continue to serve ...
... 25, 2011 New England Research Institutes (NERI) today ... from the National Institutes of Health (NIH) for the ... (PHN). PHN is a multi-center clinical research network started ... Blood Institute (NHLBI) of the National Institutes of Health, ...
... SEATTLE, Oct. 25, 2011 Cell Therapeutics, Inc. ("CTI" or ... results for the third quarter ended September 30, 2011. ... Company as we move pixantrone one step closer to potential ... Bianco, M.D., CEO of Cell Therapeutics, Inc. "We believe the ...
Cached Biology Technology:Quest Diagnostics Initiates CEO Succession Process 2New England Research Institutes (NERI) Announces Additional $45M NIH Grant to Support the Pediatric Heart Network 2New England Research Institutes (NERI) Announces Additional $45M NIH Grant to Support the Pediatric Heart Network 3Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones 2Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones 3Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones 4Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones 5Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones 6
Request Info...
... The integration of 2D polyacrylamide gel electrophoresis ... regarded as a core technology platform for ... power for complex samples limited only in ... small and large proteins. Quantitative image based ...
... Pfx DNA Polymerase is ideal for ... downstream applications such as cloning and ... by a proprietary enzyme preparation containing ... with proofreading (3'Cut Site5' exonuclease) activity. ...
... PLAU N-term Antibody This antibody is ... conjugated synthetic peptide selected within aa 50~150 ... supplied in PBS with 0.09% (W/V) sodium ... protein G column and eluted out with ...
Biology Products: