Navigation Links
The cellular intricacies of cystic fibrosis
Date:9/19/2011

Bethesda, Md. (Sept. 19, 2011) When researchers discovered the primary genetic defect that causes cystic fibrosis (CF) back in 1989, they opened up a new realm of research into treatment and a cure for the disease. Since then, scientists have been able to clone the defective gene and study its effects in animals. Now researchers at the University of North Carolina at Chapel Hill have developed a technique for observing the defects at work in human tissue donated by patients with CF.

This technique has yielded an extraordinary view of the cellular intricacies of CF, which Martina Gentzsch, assistant professor of cell and developmental biology, will discuss at the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 in Pacific Grove, Calif. The meeting is sponsored by the American Physiological Society. Her poster presentation is entitled, "The Cystic Fibrosis Transmembrane Conductance Regulator Inhibits Proteolytic Stimulation of ENaC."

Ion Transport Processes in CF

Cystic fibrosis is caused by a mutation in the gene that encodes a protein called cystic fibrosis transmembrane conductance regulator (CFTR), which functions as a chloride channel at the surface of airways and moves chloride out of the cells. CFTR also regulates another protein called epithelial sodium channel (ENaC), which is responsible for transporting sodium into cells. Thus far, scientists have been able to establish that when the CFTR mutation is present, ENaC becomes overactive and causes the cells in the lungs to absorb too much sodium. Water follows the sodium from the cells' surfaces into the cells, and as a result, the airways become dry and mucous becomes thick and sticky, leading to infections in the lungs.

To observe how CFTR regulates ENaC, Dr. Gentzsch and her team took cells from healthy lung tissue and CF lung tissue and maintained them in a liquid medium. The cells' surface
'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cellular metabolism self-adapts to protect against free radicals
2. New cellular surprise may help scientists better understand human mitochondrial diseases
3. Cellular laser microsurgery illuminates research in vertebrate biology
4. Cellular stress can induce yeast to promote prion formation
5. Researchers provide means of monitoring cellular interactions
6. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
7. How muscle develops: A dance of cellular skeletons
8. Harvard scientists see the early cellular cause of dry eye disease for the first time
9. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
10. WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
11. Extracting cellular engines may aid in understanding mitochondrial diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
(Date:11/4/2014)... about the way our bodies are assembled during early ... they are supposed to become a nerve or a ... correct place and alignment? Researchers at the University of ... a new study, UM researchers describe the signaling systems ... at the head-trunk region. Their discovery may have important ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Jet-fueled electricity at room temperature 2The inside story: How the brain and skull stay together 2
... − Famous for their sluggishness, turtles have been slow ... place on the evolutionary tree. For decades, paleontologists who ... disagreed about whether turtles are more closely related to ... from the Mount Desert Island Biological Laboratory in Bar ...
... boost the body,s defenses against cancer is called adoptive ... of their own immune cells. This therapy, currently tested ... its limitations: Removing immune cells from a patient and ... extremely expensive and not always technically feasible. Weizmann ...
... Since 1999, several outbreaks of West Nile Virus, which ... birds to humans by blood-sucking mosquitoes, have been seen in ... certain how the virus migrated here and they don,t ... Prof. Ella Mendelson of Tel Aviv University,s School of Public ...
Cached Biology News:Discovery places turtles next to lizards on family tree 2Universal donor immune cells 2Catching the West Nile virus in action 2
(Date:11/26/2014)... 26, 2014 The announced sales of three ... is looking to expand in non-healthcare areas, says Kalorama ... market research firm says that  Siemens is the third ... survey of the IVD market , with 5.5 billion ... its composition would likely affect IVD market shares.  ...
(Date:11/26/2014)... PMG Research, Inc. announced today the ... network of sites that provide clinical research services to pharmaceutical ... lives through its partnerships with large physician practices and integrated ... locations in the Southeastern United States and spans over 60 ... board will be held by: Dr. Robert Holmes, MD, ...
(Date:11/26/2014)... November 25, 2014 The Pittcon marketing ... official conference and exposition mobile app, ... download in the App Store for iOS and Android ... resource tool before, during and after the event. It ... on exhibiting companies, technical sessions, Conferee Networking sessions and ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 2014 ... is an in-depth research report on the Global ... report introduces Palmitic Acid, basic information, including definition, ... analysis, and news analysis, etc. , For ... Palmitic Acid market in China and ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3Pittcon Releases 2015 Mobile App 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3
... in its infancy, stem cell therapy market to grow rapidly ... over next ... detailed analysis of the stem cell therapy market in,its US Markets for Stem ... therapies is in its infancy, it will,grow rapidly as products are approved in ...
... Tissue Ligating ... ... surgical device company, has been named a 2007 Innovator of the,Year ... for its newest Tissue Ligating Shears, the TLS3,which uses the Company,s ...
... Action Date, IRVINE, Calif., Sept. 13 Spectrum,Pharmaceuticals, ... amendment to,the New Drug Application (NDA) for ISO-Vorin(TM) (levofolinic ... U.S. Food & Drug Administration,(FDA). The FDA has targeted ... of the ISO-Vorin(TM) application. ISO-Vorin(TM) is the pure,active isomer ...
Cached Biology Technology:Stem Cell Therapy to Skyrocket by 2017 2Society of Laproendoscopic Surgeons Names Starion Instruments 2007 Innovator of the Year 2FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 2FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 3
See product name for description....
... PhastGel DNA Silver Staining Kit, ... polyacrylamide gels.Separate proteins and peptides on ... time and improve reproducibility with precast ... detection sensitivity comparable to that of ...
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Human HAPLN1 MAb (Clone 316119) Protein Family: Hyaluronan (HA) & HA Binding Proteins, Proteoglycan Regulators...
Biology Products: