Navigation Links
The cell's 'New World'
Date:6/1/2012

In one of the most famous faux pas of exploration, Columbus set sail for India and instead 'discovered' America. Similarly, when scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, set out to find enzymes the proteins that carry out chemical reactions inside cells that bind to RNA, they too found more than they expected: 300 proteins previously unknown to bind to RNA more than half as many as were already known to do so. The study, published online today in Cell, could help to explain the role of genes that have been linked to diseases like diabetes and glaucoma.

"We are very excited that, unlike Columbus, we found what we were looking for: well-known enzymes that bind to RNA," says Matthias Hentze, who led the study at EMBL with Jeroen Krijgsveld. "But we never thought there was still so much unexplored territory, so many of these RNA-binding proteins to be discovered."

Almost 50 of the new proteins Hentze and Krijgsveld found are encoded by genes known to be mutated in patients suffering from a variety of diseases, from diabetes and glaucoma to prostate and pancreatic cancers. This finding opens new avenues for researchers studying these disorders. It raises the possibility that such conditions could be caused by a malfunction not in the protein's previously established function, but in its potential role in RNA control.

The idea that enzymes might also function as genetic regulators, by binding to RNA and controlling its function, had already been raised by previous work in the Hentze lab. To investigate further, Alfredo Castello, Bernd Fischer at EMBL and colleagues developed a new method for identifying and isolating all proteins that bind to RNA in living cells. The new approach will have many further uses, as it can be applied to other cell types and conditions, to explore which proteins bind to RNA under different circumstances. This will enable scientists to study how the cell's machinery adapts to stressful situations, responds to drugs or to changes in metabolism, or is altered in disease.


'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. Training cells to perform Boolean functions? Its logical
2. Heart Damage Repaired By Reprogramming Resident Fibroblasts into Functioning Heart Cells
3. New stem cell technique promises abundance of key heart cells
4. U of M study finds titan cells protect Cryptococcus
5. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
6. Math predicts size of clot-forming cells
7. New microscope uses rainbow of light to image the flow of individual blood cells
8. Growth factor in stem cells may spur recovery from MS
9. A cells first steps: Building a model to explain how cells grow
10. Nature: Microscope looks into cells of living fish
11. New York Stem Cell Foundation scientist grows bone from human embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 22, 2017 , ... A new Technology ... Diego, California, this August will feature high-level speakers on quantum devices, graphene electronic ... Optics and Photonics, the largest multidisciplinary optical sciences meeting in North America, will ...
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that ... ranging from food poisoning and catheter infections to gum disease and the rejection of ... billions of dollars per year, there is currently a paucity of means for preventing ...
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore biotech firm, PathSensors, announced ... community in developing and issuing recommendations to grow Maryland's biohealth industry and position ... 2023. , The recommendations are contained in a report from ...
(Date:5/19/2017)... York (PRWEB) , ... May 19, 2017 , ... In ... in treating gait disorders, Biodex Medical Systems, Inc. announces the release of their Gait ... therapy has been joined with a biomedical system to aid in rehabilitating individuals with ...
Breaking Biology Technology: