Navigation Links
The brain knows what the nose smells, but how? Stanford researchers trace the answer
Date:2/4/2011

Mice know fear. And they know to fear the scent of a predator. But how do their brains quickly figure out with a sniff that a cat is nearby?

It's a complex process that starts with the scent being picked up by specific receptors in their noses. But until now it wasn't clear exactly how these scent signals proceeded from nose to noggin for neural processing.

In a study to be published in Nature (available online now to subscribers), Stanford researchers describe a new technique that makes it possible to map long-distance nerve connections in the brain. The scientists used the technique to map for the first time the path that the scent signals take from the olfactory bulb, the part of the brain that first receives signals from odor receptors in the nose, to higher centers of the mouse brain where the processing is done.

"No one could trace signals across neural connections to a specific type of neuron at a specific location before," said biology Professor Liqun Luo. This is Luo's first study of the mouse olfactory system, but his lab has spent 10 years studying olfactory pathways in the fruit fly. Because mouse brains are so much larger and more complex that those of flies, Luo and postdoctoral researcher Kazunari Miyamichi had to develop an entirely new experimental technique.

These techniques can be used to do more than just study how mice smell. "The tools we've developed can be applied to trace neural connections of any part of the nervous system," Luo said. The tools could be used to understand how mouse brains process information from their other senses, or how the brain controls movement. The tools could also be adapted for use in rats and other mammalian species, he said.

To trace the neural pathways, the researchers injected mouse brains with two viruses, one after the other.

The researchers first injected a low-grade virus into the higher centers of a mouse brain, where it infected near
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientific research reveals brain alterations linking omega 3 deficit with depression
2. Neurobiologists find that weak electrical fields in the brain help neurons fire together
3. Early tests find nanoshell therapy effective against brain cancer
4. Brain can learn to overcome sleep apnea: U of T scientist
5. Learn more quickly by transcranial magnetic brain stimulation
6. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
7. New molecule could save brain cells from neurodegeneration, stroke
8. Reducing diet early in pregnancy stunts fetal brain development
9. New technique to see neurons of the deep brain for months at a time developed at Stanford
10. LCD projector used to control brain and muscles of tiny organisms such as worms
11. Researchers show how Alzheimers plaques lead to loss of nitric oxide in brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The brain knows what the nose smells, but how? Stanford researchers trace the answer
(Date:9/16/2014)... has its own bacterial identity. That,s the conclusion of ... who studied the genetic fingerprints of bacteria on 57 ... "This study demonstrates for the first time that host ... strategies possess very different microbial communities on their leaves," ... researcher in the UO,s Institute of Ecology and Evolution ...
(Date:9/16/2014)... new school year, a new football season and another ... September, SpaceX,s Dragon spacecraft is scheduled to blast off ... part of the company,s fourth contracted mission to the ... third suite of research investigations sponsored by the Center ... the role of managing the U.S. National Laboratory on ...
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
Breaking Biology News(10 mins):Microbiome research shows each tree species has a unique bacterial identity 2CASIS research set for launch aboard SpaceX mission to space station 2CASIS research set for launch aboard SpaceX mission to space station 3The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3
... Columbia University Medical,Center have discovered a way to overcome ... its tendency to kill normal cells in the,process of ... Jan. 25 issue of the Proceedings of the,National Academy ... by incorporating it into a specially designed,virus. The virus ...
... unlock the secret to quicker, more effective treatment of TB ... bacteria are active again, the disease becomes treatable using common ... of this protein will lead the way to designing drugs ... In England and Wales around 400 people die each year ...
... been trying to establish the cause of a repulsive ... DNA and other biomolecules, when they are very close ... know as hydration force. , Jordi Faraudo, a researcher ... de Barcelona, and Fernando Bresme of the Department of ...
Cached Biology News:Columbia research lifts major hurdle to gene therapy for cancer 2UAB scientists discover the origin of a mysterious physical force 2
(Date:9/17/2014)... 2014 The Pistoia Alliance, a ... the barriers to innovation in life sciences R&D ... Carmen Nitsche as Executive Director Business Development North ... global reach. , Carmen joins the Pistoia Alliance ... Development. At Accelrys, she managed various life sciences ...
(Date:9/16/2014)... energy from jaw movements has been created by a ... that the device can generate electricity from eating, chewing ... or wearable electronic devices, such as hearing aids, cochlear ... first results of the device,s performance have been published ... Materials and Structures . , Jaw movements have proved ...
(Date:9/16/2014)... for radar domes have now refined the technology to ... The new work by Rice chemist James Tour and ... skyscrapers free of ice and fog while retaining their ... was introduced this month in the American Chemical Society ... The material is made of graphene nanoribbons, atom-thick strips ...
(Date:9/16/2014)... 16, 2014 CIRTEC Medical Systems’ Board ... as CEO of CIRTEC. , “I am delighted ... the Company.” noted Brian Highley. “The company has made ... strong organic growth over the past two years. The ... to improve and expand the services Cirtec offers its ...
Breaking Biology Technology:Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2'Smart material' chin strap harvests energy from chewing 2Nanoribbon film keeps glass ice-free 2
... efficient: BASF research scientists are helping to revolutionize ... aid of three-dimensional photonic crystals. In a three-year ... these crystals together with partners such as Hanover ... the Technical University of Denmark and the Ecole ...
... Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) announced today that ... on the progress of,Sangamo,s ZFP Therapeutic development programs and ... (ET) on Wednesday, November 28,2007 at the Piper Jaffray ... The presentation will be webcast live and may be ...
... Nov. 20 China Biopharma,Inc. (OTC Bulletin Board: ... take closer control and to better improve its ... away from the increasingly competitive and,low margin vaccine ... "We plan to take more control on the ...
Cached Biology Technology:3-D photonic crystals will revolutionize telecommunications 23-D photonic crystals will revolutionize telecommunications 3Sangamo BioSciences to Present at the Piper Jaffray Health Care Conference 2China Biopharma, Inc. Announces New Plan of Operation 2
SHEEP ANTI HUMAN CATHEPSIN G...
MOUSE ANTI BOVINE CD335:ALEXA 488 Immunogen: Fusion protein consisting of the extracellular region of bovine CD335....
Template and primers for preparation of internal control spots...
AedestaTM Animal Organ/Tissue Perfusion Soln....
Biology Products: