Navigation Links
The brain cannot be fooled by artificial sweeteners
Date:9/22/2013

The results of the new study imply that it is hard to fool the brain by providing it with 'energyless' sweet flavours. Our pleasure in consuming sweet solutions is driven to a great extent by the amount of energy it provides: greater reward in the brain is attributed to sugars compared to artificial sweeteners.

Professor Ivan de Araujo, who led the study at Yale University School of Medicine USA, says: "The consumption of high-calorie beverages is a major contributor to weight gain and obesity, even after the introduction of artificial sweeteners to the market. We believe that the discovery is important because it shows how physiological states may impact on our choices between sugars and sweeteners.

"Specifically, it implies that humans frequently ingesting low-calorie sweet products in a state of hunger or exhaustion may be more likely to 'relapse' and choose high calorie alternatives in the future.

"The results suggest that a 'happy medium' could be a solution; combining sweeteners with minimal amounts of sugar so that energy metabolism doesn't drop, while caloric intake is kept to a minimum."

The study identified a specific physiological brain signal that is critical for determining choice between sugars and sweeteners. This signal regulates dopamine levels a chemical necessary for reward signalling in the brain and only arises when sugar is broken down into a form where it is usable as fuel for cells of the body to function.

Research was performed in mice, using a combination of behavioural testing involving sweeteners and sugars, whilst measuring chemical responses in brain circuits for reward. The researchers believe the findings are likely to reflect in humans.

Professor de Araujo says: "According to the data, when we apply substances that interfere with a critical step of the 'sugar-to-energy pathway', the interest of the animals in consuming artificial sweetener decreases significantly, along with important reductions in brain dopamine levels.

"This is verified by the fact that when hungry mice who thus have low sugar levels are given a choice between artificial sweeteners and sugars, they are more likely to completely switch their preferences towards sugars even if the artificial sweetener is much sweeter than the sugar solution."

Now that the team know that dopamine cells are critical in sugar/sweetener choice, they hope to identify the associated receptors and pathways in the brain.


'/>"/>

Contact: Ivan E de Araujo
ivan.araujo@yale.edu
203-747-5476
Wiley
Source:Eurekalert

Related biology news :

1. WUSTL engineer using Jello to study waves in brain from traumatic impact
2. Schizophrenia: Its in the wiring of the brain
3. Multiple sclerosis appears to originate in different part of brain than long believed
4. Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting
5. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
6. Finally mapped: The brain region that distinguishes bits from bounty
7. What is the brain telling us about the diagnoses of schizophrenia and bipolar disorder?
8. Discovery helps to unlock brains speech-learning mechanism
9. Learning a new language alters brain development
10. Human brains are hardwired for empathy, friendship, study shows
11. Playing video games can boost brain power
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/9/2017)... ... October 09, 2017 , ... The ... medical marijuana products targeting the needs of consumers who are incorporating medical marijuana ... place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, The ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
Breaking Biology Technology: