Navigation Links
The bowels of infection
Date:10/20/2009

Atlanta, GA Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.

CMV infects between 50% and 80% of adults in the United States. Most people who are infected have no symptoms, and the virus remains hidden but inactive in the body for the rest of the person's life unless activated by suppression of the immune system.

IBD, which affects between 1 and 1.4 million people in the United States, causes pain, vomiting, and diarrhea in affected individuals as well as leads to an increased risk for colorectal cancer. Acute CMV infection exacerbates IBD; however, the effects of latent CMV infection on the development and/or severity of IBD have not been studied.

Researchers led by Dr. Andrew Gewirtz at Emory University in Atlanta, GA therefore examined IBD development in mice with latent CMV infection. They found that while latent CMV infection did not induce IBD, it exacerbated the severity of intestinal inflammation if colitis were already present. In addition, CMV infection resulted in increased levels of intestinal white blood cells and heightened immune responses to normally harmless bacteria found in the intestine; which are associated with IBD severity. Therefore, modulation of mucosal immunity by latent CMV infection may contribute to the pathogenesis of IBD.

Onyeagocha et al suggest that "latent infection by CMV, and perhaps other common viruses, may modulate mucosal immunity and, consequently, alter one's susceptibility to developing severe acute colitis in response to various challenges and, consequently, may predispose to developing IBD." In future studies, Dr. Gewirtz and colleagues plan to use "retrospective serologic analysis [to] confirm the notion that latent
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Immune cells predict outcome of West Nile virus infection
2. Mounting a multi-layered attack on fungal infections
3. Single host gene may hold key to treating both ebola and anthrax infections
4. Test helps in fight against lung infections and for treating other life-threatening infections
5. Stress signals link pre-existing sickness with susceptibility to bacterial infection
6. Researchers capture bacterial infection on film
7. In vitro antibody production enables HIV infection detection in window period -- key to safer blood
8. Forsyth scientists suggest linkages between obesity and oral bacterial infection
9. Fruit and vegetable intake in pregnant women reduces risk of upper respiratory tract infection
10. Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection
11. Singapore nanotechnology combats fatal brain infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... the "Access Control Market by Product, Application & ... report to their offering. , This ... to reach $10.4 billion by 2020, with an estimated ... report covers the products types such as contact cards ...
(Date:3/10/2015)... BOULDER, Colo. , March 10, 2015 ... Space Flight "Personalized Medicine in Human ... Ph.D. and Thomas J. Goodwin , Ph.D. was ... articles of the past two years. Specifically, ... three most downloaded scientific papers published in 2013 and ...
(Date:3/5/2015)... March 5, 2015 In Brazil ... companies already using these solutions and 42 percent planning to ... latter, approximately 25 percent of the companies will be investing ... the majority of companies in the region are currently opting ... hybrid model will command significant attention in the coming years. ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... in their genes" is a common refrain from scientists when ... and beyond. Up until now, research has focused on ... levels of HDL ("good") cholesterol. But researchers at Albert ... of Psychology of Yeshiva University have found that personality ...
... Preventice, Inc. , a developer of mobile health ... it is the latest to join medical device ... payors that are integrating with Qualcomm Life Inc., ... their 2net™ Ecosystem. (Logo: http://photos.prnewswire.com/prnh/20120417/CG89172LOGO ...
... Diego have discovered that a small dose of a commonly ... affects their ability to recruit their nestmates to otherwise good ... this week,s issue of the Journal of Experimental Biology ... bee-pollinated crops and shed light on one of the main ...
Cached Biology News:'Personality genes' may help account for longevity 2Preventice Expands Options for Wireless Patient Monitoring with Qualcomm Life 2Commonly used pesticide turns honey bees into 'picky eaters' 2
(Date:3/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... solutions for the detection of foodborne pathogens, today ... and full year ended December 31, 2014. ... quarter ended December 31, 2014 was $1.4 million ... 2013 and $1.5 million for the third quarter ...
(Date:3/26/2015)... March 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... after dealing with certain matters, including the appointment of ... on March 26, 2015 (the "Meeting") was adjourned, as ... 2015 at 11:00 a.m. ( Toronto ... changed from that previous disclosed. The Meeting will reconvene ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
(Date:3/26/2015)... March 26, 2015 Neogen Corporation (NASDAQ: ... the third quarter of fiscal 2015, which ended Feb. ... prior year,s $6,575,000. Earnings per share in the current ... Current year-to-date net income increased 17% over prior year ... or $0.56 per share, for the same period a ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7SQI Diagnostics Inc. Announces Adjournment of Meeting 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
... Technology (NIST) has issued a new ruler, and even for ... records. Designed to be the most accurate commercially available "meter ... standard for X-ray diffractionboasts uncertainties below a femtometer. That,s 0.000 ... a neutron. The new ruler is in the form ...
... , , , ... a prospective registry showed good safety in a broad population of patients ... Genous Bio-engineered R stent for ST-elevation myocardial infarction (STEMI). , , ... of major adverse cardiac events (MACE) was 6.7 percent and the rate ...
... SAN DIEGO, Sept. 22 SoluLinK, Inc., a leader ... Catalyst, making conjugation at least 20 times faster than before ... , , Up to now, researchers, conjugation ... poor yields, poor quality and more labor and time consuming ...
Cached Biology Technology:New NIST nano-ruler sets some very small marks 2OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) is Safe in a Broad Population of Patients with Primary PCI for STEMI 2OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) is Safe in a Broad Population of Patients with Primary PCI for STEMI 3SoluLinK Introduces Product that Links All Biomolecules Greater Than 20 Times Faster with 100% Yields 2
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
... to Uridine Phosphorylase 1 ( Abpromise ... Antigen: Synthetic peptide: MAATGANAEK AESHNDCPVR LLNPNIAKMK ... corresponding to amino acids 1-99 of Human ... Gene ID: 7378 ...
Request Info...
Syne-1 (N-19)...
Biology Products: