Navigation Links
The birth and death of dopamine neurons: A new model for neurodegeneration
Date:12/10/2007

The gradual loss of dopamine neurons is a hallmark of many neurodegenerative diseases - Parkinsons Disease chief among them. Stem cell biology and regenerative medicine offer novel therapies for the restoration of dopamine neurons. This week in the online open-access journal PLoS Biology Dr. Raja Kittappa, Dr. Wendy Chang, Dr. Rajeshwar Awatramani, and Dr. Ronald McKay show that the transcription factor FOXA2 plays a central role in the birth and death of dopamine neurons in the midbrain. By defining precursors of dopamine neurons in the ventral midbrain, Kittappa et. al. have discovered that dopamine neurons are derived from organizer cells in the floor plate (the ventral cells of the neural tube and the embryonic foundation of the central nervous system). They also show that FOXA2 specifies the floor plate and actually induces the birth of dopamine neurons. Mice with only a single copy of the foxa2 gene acquire motor deficits and a late-onset degeneration of dopamine neurons. This spontaneous cell death preferentially affects neurons associated with Parkinson disease. This work provides new strategies to generate neurons in the laboratory and to block their death in old age.


'/>"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Risk of common vaginal infection linked to preterm birth appears higher for blacks
2. Birth records hold pancreatic cancer clue
3. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
4. Birth of an iceberg
5. Bleeding, not inflammation, is major cause of early lung infection death
6. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
7. Scientists find how amber becomes death trap for watery creatures
8. Synthetic compound promotes death of lung-cancer cells, tumors
9. Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice
10. Leading cause of death in preemies might be controlled by resetting a molecular switch
11. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... , ... August 11, 2017 , ... Algenist continues to ... formulation unlocking collagen like never before. , Collagen is the key structural element ... market with Liquid Collagen™, which include: , First to ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers from three Philadelphia ... August 14th through the 16th, the University City Science Center will kick off ... 2016, provides Philadelphia-based middle school educators an opportunity for professional development related to ...
(Date:8/10/2017)... Bahama (PRWEB) , ... August 09, 2017 , ... Okyanos ... will take place at the Pelican Bay Hotel in Freeport, Grand Bahama on September ... pre-registration is required. , With oversight from the Ministry of Health’s National Stem ...
(Date:8/10/2017)... ... August 10, 2017 , ... ... establishing Kinokuniya Company Ltd. as its exclusive sales representative for SPIE Journals in ... for the SPIE Digital Library in Japan. , “We look forward to expanding ...
Breaking Biology Technology: