Navigation Links
The battle of the morphogens: How to get ahead in the nervous system
Date:9/1/2011

ilar constructs in the heads of frog embryos. "These results suggest that dnTcf7l2 has been highly conserved during evolution for its ability to powerfully repress Wnt target genes," says Vacik.

Previously, other investigators have found that mice harboring mutations in Wnt inhibitor genes often exhibit severely truncated forebrains. So the group asked whether loss of the dominant negative Tcf7l2 would perturb head formation. To test that they injected frog embryos with a short inhibitory RNA designed to artificially degrade the frog version of truncated Tcf7l2.

The resulting embryos were essentially headless, showing complete loss of structures in front of the midbrain, the very point where Wnt signaling is brought to a grinding halt in normal mouse or frog embryos by the opposing ventral morphogen sonic hedgehog and its henchman Vax. This is the first study to provide an explanation for how this molecular line in the sand is drawn.

"Our results illustrate a very basic principle-that if you have the power to turn something on, you must have the ability to turn it off. Otherwise, you set up a situation of uncontrolled signaling," says Lemke.

The disastrous outcome of uncontrolled signaling is also illustrated by the fact that cancer cells often show aberrant reactivation of factors governing normal development. Some colon cancer tumors, for example, show high levels of Tcf7l2's partner -catenin and resulting unchecked Wnt signaling causes the disease. More intriguingly, the inability of tumor cells to make a short, inhibitory form of a factor related to Tcf7l2 is also associated with tumorigenicity.

"So Wnts and sonic hedgehog may be in competition in colon cancer just like they are in the brain," Lemke says. "Our work could provide insight into how that happens mechanistically. "


'/>"/>
Contact: Andy Hoang
Ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Trudeau Institute announces new discovery in battle against infections
2. Battle won against Asian tiger mosquito
3. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
4. Plant pathologist finding Kansas wheat fields a molecular battleground this season
5. Stevens biomedical engineering students fight hypothermia on the battlefield
6. Battle scars found on an ancient sea monster
7. New vitamin D-fortified food could battle widespread need for the sunshine vitamin
8. Whats coming next in the biochemical battle of the bulge?
9. Insect scientists battle invasive species in Hawaii
10. $40 million helps Cornell lead global battle against wheat pathogen that threatens food security
11. NIH funds center at Arizona State to battle infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The battle of the morphogens: How to get ahead in the nervous system
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
(Date:8/27/2014)... The IEEE Engineering in Medicine and Biology Society (EMBS) ... (EMBC,14), this year being held at the Sheraton Chicago ... , from Tuesday, August 26 through Saturday, August 30. ... in science, medicine, and engineering are registered to attend. ... This year,s conference theme is Discovering, Innovating, ...
(Date:8/27/2014)... are often depicted as giant, frightening beasts. But every ... of a rock slab containing fossils of 24 very ... a group of hatchlings overseen by a caretaker, according ... , Penn,s Brandon P. Hedrick and Peter Dodson led ... of Natural History, where the specimen is held. Hedrick ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3
... enzyme that naturally produces alkanes -- long carbon-chain molecules ... in gasoline -- have figured out why the natural ... with that knowledge, they,ve devised a strategy to keep ... at the U.S. Department of Energy,s Brookhaven National Laboratory ...
... boost of activity at the back of the ... patients would respond to an experimental rapid-acting antidepressant, ... "We have discovered a potential ... treatment selection by revealing brain-based differences between patients," ...
... MD The Federation of American Societies for Experimental ... Science Research Conference (SRC): NAD Metabolism & Signaling. ... NAD and related metabolites are involved in a wide ... diseases, including type 2 diabetes and other metabolic complications. ...
Cached Biology News:Scientists turn toxic by-product into biofuel booster 2Scientists turn toxic by-product into biofuel booster 3Imaging biomarker predicts response to rapid antidepressant 2Imaging biomarker predicts response to rapid antidepressant 3FASEB SRC announces conference registration open for: NAD Metabolism & Signaling 2
(Date:8/27/2014)... 2014  A novel biomarker for rheumatoid arthritis ... identify early-stage disease, when treatment can often arrest ... new study in The Journal of Rheumatology. ... DGX ) and other institutions found that elevated ... antibody-serum testing, including rheumatoid factor (RF) and anti-citrullinated ...
(Date:8/27/2014)... Belmont, Mass. (PRWEB) August 27, 2014 ... of top technology vendors,” said Ven Thangaraj, CEO of ... imaging solutions that are taking the imaging corelab market ... trial sponsors, corelabs and research organizations to efficiently and ... and prepare the data to be analyzed and read ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 Guggenheim ... Guggenheim Partners, today announced the hiring of veteran equity ... senior equity analyst. Mr. Butler will focus on the ... our team a wealth of experience and a broad ... Ferrarie , Senior Managing Director and Head of Equities ...
(Date:8/27/2014)... 27, 2014 Reportbuyer.com has added a ... Opportunity - A Rational View ... Nanotech? A similar amount of hype currently ... from microelectronics to water treatment, but is graphene ... of the Graphene Opportunity Report, authored by ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... YORK, Oct 6 NeoStem, Inc. (NYSE Amex: NBS ... storage of adult stem cells for future medical need and ... Technology that uses very small embryonic-like stem cells isolated from ... a grant of $108,746 for the repair of bone defects ...
... ... the Broad Institute,s NIH-funded Molecular Libraries and Imaging Initiative , ... Lexington, Mass. (USA) and Basel, Switzerland (PRWEB) ... for pharmaceutical R&D and related life sciences, today announced that the Broad Institute of ...
... MELBOURNE, Australia, Oct. 5 Cytopia Limited (ASX: CYT) ... BioSciences Inc. ("YM") have signed an exclusive and binding ... YM will acquire all of the issued shares and ... scheme(s) of arrangement ("Scheme(s)") and shareholders (and optionholders if ...
Cached Biology Technology:NeoStem, Inc. Awarded NIH Research and Research Infrastructure 'Grand Opportunities' Grant 2NeoStem, Inc. Awarded NIH Research and Research Infrastructure 'Grand Opportunities' Grant 3Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 2Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 3Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 4Cytopia Merger with Toronto-based YM BioSciences Inc. 2Cytopia Merger with Toronto-based YM BioSciences Inc. 3Cytopia Merger with Toronto-based YM BioSciences Inc. 4Cytopia Merger with Toronto-based YM BioSciences Inc. 5Cytopia Merger with Toronto-based YM BioSciences Inc. 6Cytopia Merger with Toronto-based YM BioSciences Inc. 7
... Once a macromolecular structure has been determined, ... to a widely diverse audience of scientists, ... printed literature and dissemination over the Internet, ... personal web pages. Printed literature has the ...
... 45° Fixed Angle Rotor ... Centra CL2, Centra CL3CL3R, and ... concentration of sputum samples and ... samples. Provides individual aerosol containment. ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Biology Products: