Navigation Links
The battle for CRTC2: How obesity increases the risk for diabetes
Date:6/21/2009

La Jolla, CAObesity is probably the most important factor in the development of insulin resistance, but science's understanding of the chain of events is still spotty. Now, researchers at the Salk Institute for Biological Studies have filled in the gap and identified the missing link between the two. Their findings, to be published in the June 21, 2009 advance online edition of the journal Nature, explain how obesity sets the stage for diabetes and why thin people can become insulin-resistant.

The Salk team, led by Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology, discovered how a condition known as ER (endoplasmic reticulum) stress, which is induced by a high fat diet and is overly activated in obese people, triggers aberrant glucose production in the liver, an important step on the path to insulin resistance.

In healthy people, a "fasting switch" only flips on glucose production when blood glucose levels run low during fasting. "The existence of a second cellular signaling cascadelike an alternate route from A to Bthat can modulate glucose production, presents the potential to identify new classes of drugs that might help to lower blood sugar by disrupting this alternative pathway," says Montminy.

It had been well established that obesity promotes insulin resistance through the inappropriate inactivation of a process called gluconeogenesis, where the liver creates glucose for fuel and which ordinarily occurs only in times of fasting. Yet, not all obese people become insulin resistant, and insulin resistance occurs in non-obese individuals, leading Montminy and his colleagues to suspect that fasting-induced glucose production was only half the story.

"When a cell starts to sense stress a red light goes on, which slows down the production of proteins," explains Montminy. "This process, which is known as ER stress response, is abnormally active in livers of obese individua
'/>"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert  

1

GOOD

Page: 1 2 3

Related biology news :

1. Queens scientists find new way to battle MRSA
2. Carbon sinks losing the battle with rising emissions
3. Researchers identify potential new weapon in battle against HIV infection
4. Color My Pyramid nutrition education program battles obesity in DC schools
5. In Vietnam, alongside progress, a battle for life
6. LSU and Ohio State battle on football field, collaborate in research field
7. In promiscuous antelopes, the battle of the sexes gets flipped
8. Amber specimen captures ancient chemical battle
9. Older climbers face uphill battle on Mount Everest
10. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
11. New guidelines to fight obesity in pregnancy issued

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The battle for CRTC2: How obesity increases the risk for diabetes
The battle for CRTC2: How obesity increases the risk for diabetes
(Date:11/24/2009)...f debate. A high-profile study a few years ago sug...rbon from trees and leaves, evidence for a very cl...stems. , But new research from the University of...lgae provide a much richer diet for fish and other...s week in the Proceedings of the National Academy...
(Date:11/23/2009)...d strain of the deadly superbug MRSAan infection-c...csposes a far greater health threat than previousl...rding to a study in the December issue of Emergin...ily picked up in fitness centers, schools, and oth...den of MRSA within hospitals, the report found. ,...
(Date:11/23/2009)...nts gathered this week for the seventh annual Nati... This year,s topic, "Synthetic Biology," brought t...hers to explore the engineering, scientific, and s...thetic biology. , Bonnie L. Bassler, professor o...is year,s conference chair, challenged the attende...
Breaking Biology News(10 mins):Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3New study finds MRSA on the rise in hospital outpatients 2Synthetic biology offers new opportunities for interdisciplinary collaboration 2Why Huntingtons Shows Up in Midlife 48864 1Why Huntingtons Shows Up in Midlife 48864 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 1New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 3Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 1Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 2Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 3
...ritical portions of the brain in those who are obe...ers have reported in the March issue of the journa...findings in obese mice show that a sensor in the b...causing a cascade of events that keeps energy bala...of the metabolic pathway remains ready to respond....
... study at UCL (University College London) finds th...ve in many species of insect including the butterf... fatigue. , The team found that when the male inse...-- the female butterfly becomes more sexually ramp... and put less effort into mating. , In some po...
...tronger than steel and more elastic than rubber: s...sistance to tearing, and toughness. Spider silk wo...dical and technical applications, and researchers ...ts and imitating their technique. A team lead by T...ch has now made a step in the right direction. As ...
Other Biology News:In obesity, brain becomes 'unaware' of fat 2In obesity, brain becomes 'unaware' of fat 3Male-killing bacteria makes female butterflies more promiscuous 2Fascinating spider silk 2
(Date:11/24/2009)..., TSXVENTURE:HTL , TORONTO,Nov.24/PRNewswir...yCalottoCapitalInc.,aleadingproviderofadvancedlase...tilityclinicmarkets,todayreportedoperationalandfin...09. , ,Q32009Highlights,-Revenuewas$1.46millionc...was66.3percentcomparedwith66.1percentinQ3,2008,-Ne...
(Date:11/24/2009)..., SANDIEGO,Nov.24,2009/PRNewswire-FirstCall/--Ar...odaythatthecompanyisscheduledtopresentatthePiperJa...9at11:30a.m.EasternTime(8:30a.m.PacificTime)attheN...esident andChiefExecutiveOfficer,isscheduledtoprov...lopmentanddiscoveryprograms. ,, Aliveaudiowebca...
(Date:11/24/2009)..., BOZEN,Italy,November24/PRNewswire/--HealthRobo...tventurewithagroupofselected,investors.Thisrecentl...eHealthRoboticsCanada,Inc.andwillmarket,install,an...,whichincludesthe,revolutionaryproductofferingsi.v...csCanadaInc.willalsoprovideassistanceonan"asneeded...
(Date:11/24/2009)... Chemical Abstracts Service (...eports that China,s patent office is now the world...ns in chemistry. China trailed Japan,s patent offi...WIPO), and the United States Patent and Trademark ...the USPTO in 2005, WIPO in 2006, and exceeded Japa...
Breaking Biology Technology:Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3
... Accelerate Trials and Commercialization, PALO AL...etin Board: AVGO), a late-stage biotechnology comp...ics for neurodegenerative,diseases, announced toda...private offering of Preferred Stock and warrants. ... and in exchange sold,3,110 shares of newly design...
... Sep. 26 NFL Hall of Fame,legendary wide receiver...am,of celebrated athletes and entertainers as a pa...ife, Inc. (Amex: SGN ) and Athletes for Life,("AF...d products and,technologies. He has joined such su...n, Rocket Ismail, Jerry Rice, Dwight Clark, and Le...
...s to illustrate wide applicability of JuvImmune an...rms, PLEASANTON, Calif., Sept. 26 Juvaris BioThe...entations at the upcoming IDSA,meeting on October ...ltiple,species of JuvImmune immunostimulant and Ju... hepatitis and HSV-2. "We are pleased that the co...
Other Biology Technology:Avicena Group Announces Closing of Private Offering 2NFL Hall of Fame Legend Fred Biletnikoff Joins AFL/Signalife Cardiovascular Protection Team 2Juvaris BioTherapeutics Announces Six Scientific Presentations at Infectious Diseases Society of America (IDSA) Meeting October 6, 2007 2
...genomic DNA from plants in 96 well plates. Plant m... well plate using large zirconia beads optimized f... velocity plate shaker (available through Mo Bio)....rane spin filter plate. The DNA is washed and then...
...ler with 384-well reaction module is used for nucl...quipped with an interchangeable, 384-well reaction...orithm temperature monitoring and control and ramp.... It includes the iCycler base with 384-well react...
... systems, known as ChemiArrayTM Mouse Cytokine Ant...h current methodologies. Besides the ability to de... a more accurate reflection of active cytokine lev...nd no amplification step is needed. Furthermore, i...
RAT LD NORMAL TISSUE ARRAY from BioGenex
Biology Products: