Navigation Links
The art of stabilizing entangled spaghetti-like materials
Date:11/28/2011

Gene therapy can only be effective if delivered by a stable complex molecule. Now, scientists have determined the conditions that would stabilise complex molecular structures that are subject to inherent attractions and repulsions triggered by electric charges at the surfaces of the molecules, in a study about to be published in EPJ E, by Valentina Mengarelli and her colleagues from the Solid State Physics Laboratory at the Paris-Sud University in Orsay, France, in collaboration with Paris 7 and vry Universities scientists.

The authors studied soluble complexes made of negatively charged DNA or another negatively charged polymer polystyrene-sulfonate (PSSNa) and a so-called condensation agent, which is a negatively charged polymer, known as linear polyethyleneimine (PEI). PEI participates in the condensation process by tying onto a molecule such as DNA, like tangled hair, to form an overall positively charged DNA/polymer complex structure.

Previous research focused mainly on non-soluble complexes, while the few attempts at focusing on soluble complexes dealt either with smaller polymers or those with a weaker electric charge, which may therefore be easier to stabilise.

The French team thus confirmed experimentally that the complexation process does not depend on the rigidity of the original molecule, be it DNA or PSSNa, but on the positive/negative electric charge ratio and on the polymer concentrations. It is the interactions between electrically charged parts within the complex that govern its properties. When the condensation agent is in excess, the positively charged complex is then attracted to negatively charged biological cell membranes. This could be used to deliver the DNA into a targeted cell nucleus as part of gene therapy treatment.

Future work will focus on using long DNA molecules and novel polymers to form complexes of controlled size and electric charge for gene therapy.


'/>"/>

Contact: Renate Bayaz
renate.bayaz@springer.com
49-622-148-78531
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education
3. Shape memory materials ready for mass production
4. We are not only eating materials, we are also eating information
5. $21.5 million for materials research at the University of Utah
6. Cold electrons to aid better design of drugs and materials
7. Materials scientist and entrepreneur Dr. John Rogers awarded $500,000 Lemelson-MIT Prize
8. Stevens conference explores latest innovations in antimicrobial biomaterials research
9. The ultimate camo: Team to mimic camouflage skill of marine animals in high-tech materials
10. Force of acoustical waves tapped for metamaterials
11. Student innovation at Rensselaer holds key to safer remote detection of dangerous materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... distance between two points is a straight line, and ... taking the familiar axiom to heart. , Though ... intense, with each racing for the chance to fertilize ... form cooperative groups that allow them to take a ... study, conducted by Heidi Fisher, a post-doctoral student working ...
(Date:7/30/2014)... joint venture between The University of Texas at San ... Center at San Antonio, has selected the winners of ... from UTSA and Lei Huang from the Health Science ... engineered ferritins for tracking and protecting neural stem cells ... focused on finding a treatment for stroke through stem ...
(Date:7/30/2014)... of $1 million from the Cornelia Cogswell Rossi Foundation ... Center. , The newly established Connie Cogswell ... develop a greater breadth and depth of knowledge of ... pace of research to improve human health. , The ... the Laboratory and its external partners, supporting research to ...
Breaking Biology News(10 mins):When cooperation counts 2When cooperation counts 3Rossi Foundation pledges $1M for JAX neurobehavioral research center 2
... Development Research Centre (IDRC) together with the Canadian Institutes ... Research Council of Canada (NSERC), and the Social Sciences ... that five research teams have been awarded a total ... on Adaptation to Climate Change (IRIACC). ...
... programs -- one involving traditional health club sessions and the ... similar amounts of weight and body fat, but the online ... them live healthier and leaner lives. "It,s counter-intuitive, ... but the activities that they do in a virtual world ...
... male bird called a golden-collared manakin performs a difficult, ... scientists report that female golden-collared manakins select mates based ... "The male jumps like he,s been ... Schlinger, professor and departmental chair of integrative biology and ...
Cached Biology News:International research initiative on adaptation to climate change announces research awards 2International research initiative on adaptation to climate change announces research awards 3ACSM: Weight loss success in a 3-D virtual world 2Again, but faster! The spectacular courtship dance of a tiny bird 2Again, but faster! The spectacular courtship dance of a tiny bird 3
(Date:7/30/2014)... BURLINGTON, Mass. , July 30, 2014 /PRNewswire/ ... surveyed pharmacy and medical directors in ... key drivers of biosimilar market penetration will be ... care organizations (MCOs) and the expected lower cost ... strategies for biosimilars that meet their pricing expectations ...
(Date:7/30/2014)... While administrative claims and other ... for a relatively long period of time, there ... use of these ‘big data’ for comparisons of ... today’s powerful computer technology with the plethora of ... holds significant promise for identifying optimal interventions for ...
(Date:7/30/2014)... With the accelerated aging of ... expenditure as well as the improved medical care ... reagent industry has been developing quickly, especially in ... Chinese in vitro diagnostics market size reached RMB22.98 ... vitro diagnostic reagents. , Read complete report ...
(Date:7/30/2014)... July 30, 2014 Yuma Regional ... and complementary therapies brings comprehensive cancer care to ... Yuma Regional Cancer Center has officially opened. A ... program includes services such as open, semi-private and ... American Cancer Society Resource Center, hematology, rehabilitation center, ...
Breaking Biology Technology:Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2
... 6 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ("China Sky ... ), a leading,fully integrated pharmaceutical company producing over-the-counter drugs ... appointment of Mr.,William Wei Lee as an independent member ... 4, 2009. Mr. Jiang Qi-Feng resigned from the,Board effective ...
... Aug. 6 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... focused on endocrine therapy and oncology, today announced that ... a corporate overview at the upcoming Canaccord Adams 29th ... at 2:00 p.m. (eastern time) at the Intercontinental Hotel ...
... WALTHAM, Mass., Aug. 6 Repligen Corporation (Nasdaq: RGEN ... ended June 30, 2009. Total revenue for the quarter was ... of fiscal year 2009. The prior year results were favorably ... for royalties on the U.S. sales of Orencia(R) prior to the ...
Cached Biology Technology:China Sky One Medical, Inc. Appoints New Independent Director 2China Sky One Medical, Inc. Appoints New Independent Director 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 2Repligen Reports First Quarter Fiscal Year 2010 Financial Results 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 4Repligen Reports First Quarter Fiscal Year 2010 Financial Results 5Repligen Reports First Quarter Fiscal Year 2010 Financial Results 6Repligen Reports First Quarter Fiscal Year 2010 Financial Results 7
Anti-human CD48/BLAST-1, clone MEM102, Monoclonal Antibody...
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
Immunogen: Synthetic peptide: N(171) H G F L S A D Q QL I K(183) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: