Navigation Links
The art of stabilizing entangled spaghetti-like materials
Date:11/28/2011

Gene therapy can only be effective if delivered by a stable complex molecule. Now, scientists have determined the conditions that would stabilise complex molecular structures that are subject to inherent attractions and repulsions triggered by electric charges at the surfaces of the molecules, in a study about to be published in EPJ E, by Valentina Mengarelli and her colleagues from the Solid State Physics Laboratory at the Paris-Sud University in Orsay, France, in collaboration with Paris 7 and vry Universities scientists.

The authors studied soluble complexes made of negatively charged DNA or another negatively charged polymer polystyrene-sulfonate (PSSNa) and a so-called condensation agent, which is a negatively charged polymer, known as linear polyethyleneimine (PEI). PEI participates in the condensation process by tying onto a molecule such as DNA, like tangled hair, to form an overall positively charged DNA/polymer complex structure.

Previous research focused mainly on non-soluble complexes, while the few attempts at focusing on soluble complexes dealt either with smaller polymers or those with a weaker electric charge, which may therefore be easier to stabilise.

The French team thus confirmed experimentally that the complexation process does not depend on the rigidity of the original molecule, be it DNA or PSSNa, but on the positive/negative electric charge ratio and on the polymer concentrations. It is the interactions between electrically charged parts within the complex that govern its properties. When the condensation agent is in excess, the positively charged complex is then attracted to negatively charged biological cell membranes. This could be used to deliver the DNA into a targeted cell nucleus as part of gene therapy treatment.

Future work will focus on using long DNA molecules and novel polymers to form complexes of controlled size and electric charge for gene therapy.


'/>"/>

Contact: Renate Bayaz
renate.bayaz@springer.com
49-622-148-78531
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education
3. Shape memory materials ready for mass production
4. We are not only eating materials, we are also eating information
5. $21.5 million for materials research at the University of Utah
6. Cold electrons to aid better design of drugs and materials
7. Materials scientist and entrepreneur Dr. John Rogers awarded $500,000 Lemelson-MIT Prize
8. Stevens conference explores latest innovations in antimicrobial biomaterials research
9. The ultimate camo: Team to mimic camouflage skill of marine animals in high-tech materials
10. Force of acoustical waves tapped for metamaterials
11. Student innovation at Rensselaer holds key to safer remote detection of dangerous materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
(Date:11/15/2016)... ROCKVILLE, Md. , Nov. 15, 2016 /PRNewswire/ ... clinical company developing therapeutics focused on the gut ... public offering of 25,000,000 shares of its common ... its common stock at a price to the ... gross proceeds to Synthetic Biologics from the offering, ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... (PRWEB) , ... December 02, ... ... (ETC), a consortium of pharmaceutical and biotechnology companies dedicated to collaboratively developing ... companies interested in supplying a vendor-supported, portable online UHPLC, with robust, probe-based ...
(Date:12/2/2016)... , December 2, 2016 The ... 2021, growing at a CAGR of 7.3% during the forecast period ... hospitals and diagnostic laboratories segment accounted for the largest share of ... ... report on global immunohistochemistry (IHC) market spread across 225 pages, profiling ...
(Date:11/30/2016)... 30, 2016  GenomOncology today announced the appointment of ... Affairs.  Dr. Coleman will oversee clinical content ... knowledge-enabled platform. The GenomOncology software suite empowers molecular pathologists with ... and clinical decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... 2016 Biotest Pharmaceuticals Corporation (BPC), a leading ... the addition of its newest plasma collection center located ... . The 15,200 square foot state-of-the-art facility officially opened ... brings the total number of BPC,s plasma collection centers ... BPC,s Chief Executive Officer said "We are pleased to ...
Breaking Biology Technology: