Navigation Links
The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
Date:2/15/2008

The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses causing hemorrhagic fevers and encephalitis

A researcher group comprising Juha Huiskonen from the University of Helsinki and structural biologists from the Karolinska Institutet in Stockholm and the Max Planck Biochemistry Institute in Mnich has solved the three-dimensional structure of the Uukuniemi virus. The Uukuniemi virus is the first bunyavirus whose structure researchers have been able to determine. Together with more detailed studies of the viral membrane proteins, knowledge of the Uukuniemi virus may provide a basis for development of drugs for treating bunyavirus diseases, such as hemorrhagic fever and encephalitis.

The findings were published in PNAS on 12 February, 2008.

The researchers solved the three-dimensional structure of the virus particle, which is only 0.0001 mm in diameter, using electron tomography and computational methods. The newly determined virus structure also serves as a model for the other bunyaviruses. Recent research surprisingly revealed that the viral membrane proteins protruding as spikes from the Uukuniemi virus surface changed their shape in an acidic environment. This phenomenon is reminiscent of the mechanism whereby influenza and dengue viruses enter their host cells. The observation helps to explain how bunyaviruses infect their host cells.

The Uukuniemi virus was first isolated in the village of Uukuniemi, Finland in the early 60s. Since then, it has proven to be an excellent model virus. Not being a human pathogen, the Uukuniemi virus is safe to work with, and yet it is very similar to many pathogenic bunyaviruses.

The Bunyaviridae viral family comprises more than 300 members and they are found worldwide. Many members of the family cause serious disease, such as hemorrhagic fever and encephalitis, for which no vaccines are available yet. Most of the bunyaviruses are transmitted by mosquitoes and ticks. The exception is hantaviruses, which belong to the Bunyaviridae family, and which are spread by voles and other rodents.


'/>"/>

Contact: Dr. Juha Huiskonen
juha.huiskonen@helsinki.fi
University of Helsinki
Source:Eurekalert

Related biology news :

1. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
2. Poxvirus potency uncovered in new atomic map
3. Great apes endangered by human viruses
4. Ebola virus disarmed by excising a single gene
5. Penn researchers shine the light of venus to learn how the herpes virus invades cells
6. Yellowstone viruses jump between hot pools
7. Iowa State researchers develop technology for early detection of viruses
8. Study proposes new theory of how viruses may contribute to cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Feline virus, antiviral drug studied to understand drug resistance
11. The reservoir of Marburg virus identified in a species of fruit bat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... Research and Markets has announced the addition of the ... report to their offering. ... The biometric vehicle access system market, in terms ... from 2016 to 2021. The market is estimated to be USD ... by 2021. The growth of the biometric vehicle access system market ...
(Date:12/15/2016)... Canada and BADEN-BADEN, Germany , ... a leading global financial services provider, today announced an agreement ... passive behavioural biometrics, to join forces. The partnership will enable ... mitigation strategies in compliance with local data protection regulation. ... In order ...
(Date:12/15/2016)... ... announced the addition of the "Global Military Biometrics Market 2016-2020" ... military biometrics market to grow at a CAGR of 7.5% during the ... an in-depth market analysis with inputs from industry experts. The report covers ... report also includes a discussion of the key vendors operating in this ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... , January 20, 2017 ... cancer is one of leading causes of death worldwide. ... Although the number of cancer related deaths increased gradually ... Rising in incidence rate of various cancers continues to ... a research report by Global Market Insights, Inc. cancer ...
(Date:1/19/2017)... Research and Markets has announced the addition of the "Cancer ... Opportunity Analysis and Industry Forecast, 2014-2022" report to their offering. ... Cancer Biomarkers ... $15,737 million by 2022 from $6,521 in 2015, growing at a ... technologies segment accounted for more than half of the revenue share ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
(Date:1/19/2017)... Research and Markets ... has announced the addition of the "Implantable Biomaterials ... report to their offering. Report Highlights: ... detailed analysis on current and future market trends to identify the investment ... as the base numbers Key market trends across the ...
Breaking Biology Technology: