Navigation Links
The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
Date:2/15/2008

The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses causing hemorrhagic fevers and encephalitis

A researcher group comprising Juha Huiskonen from the University of Helsinki and structural biologists from the Karolinska Institutet in Stockholm and the Max Planck Biochemistry Institute in Mnich has solved the three-dimensional structure of the Uukuniemi virus. The Uukuniemi virus is the first bunyavirus whose structure researchers have been able to determine. Together with more detailed studies of the viral membrane proteins, knowledge of the Uukuniemi virus may provide a basis for development of drugs for treating bunyavirus diseases, such as hemorrhagic fever and encephalitis.

The findings were published in PNAS on 12 February, 2008.

The researchers solved the three-dimensional structure of the virus particle, which is only 0.0001 mm in diameter, using electron tomography and computational methods. The newly determined virus structure also serves as a model for the other bunyaviruses. Recent research surprisingly revealed that the viral membrane proteins protruding as spikes from the Uukuniemi virus surface changed their shape in an acidic environment. This phenomenon is reminiscent of the mechanism whereby influenza and dengue viruses enter their host cells. The observation helps to explain how bunyaviruses infect their host cells.

The Uukuniemi virus was first isolated in the village of Uukuniemi, Finland in the early 60s. Since then, it has proven to be an excellent model virus. Not being a human pathogen, the Uukuniemi virus is safe to work with, and yet it is very similar to many pathogenic bunyaviruses.

The Bunyaviridae viral family comprises more than 300 members and they are found worldwide. Many members of the family cause serious disease, such as hemorrhagic fever and encephalitis, for which no vaccines are available yet. Most of the bunyaviruses are transmitted by mosquitoes and ticks. The exception is hantaviruses, which belong to the Bunyaviridae family, and which are spread by voles and other rodents.


'/>"/>

Contact: Dr. Juha Huiskonen
juha.huiskonen@helsinki.fi
University of Helsinki
Source:Eurekalert

Related biology news :

1. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
2. Poxvirus potency uncovered in new atomic map
3. Great apes endangered by human viruses
4. Ebola virus disarmed by excising a single gene
5. Penn researchers shine the light of venus to learn how the herpes virus invades cells
6. Yellowstone viruses jump between hot pools
7. Iowa State researchers develop technology for early detection of viruses
8. Study proposes new theory of how viruses may contribute to cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Feline virus, antiviral drug studied to understand drug resistance
11. The reservoir of Marburg virus identified in a species of fruit bat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 18, 2017 , ... Dr. Ralph Mobbs ... the Prince Of Wales Private Hospital. The procedure was performed on a 46-year-old ... failed conservative treatments prior to undergoing surgery. , The AxioMed viscoelastic disc is ...
(Date:5/18/2017)... ... ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, today ... doubled in size over the past six months with the acquisition of businesses in ... CSM as Chief Financial Officer. Roger has over 25 years of experience in ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... expertise, and further enhances its scientific power by providing investigators access to ... has agreed to join the scientific advisory board. “We are committed to ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is honored that ... for Medical Devices conference in Brussels, Belgium. , Crowley played a crucial role ...
Breaking Biology Technology: