Navigation Links
The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses

The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses causing hemorrhagic fevers and encephalitis

A researcher group comprising Juha Huiskonen from the University of Helsinki and structural biologists from the Karolinska Institutet in Stockholm and the Max Planck Biochemistry Institute in Mnich has solved the three-dimensional structure of the Uukuniemi virus. The Uukuniemi virus is the first bunyavirus whose structure researchers have been able to determine. Together with more detailed studies of the viral membrane proteins, knowledge of the Uukuniemi virus may provide a basis for development of drugs for treating bunyavirus diseases, such as hemorrhagic fever and encephalitis.

The findings were published in PNAS on 12 February, 2008.

The researchers solved the three-dimensional structure of the virus particle, which is only 0.0001 mm in diameter, using electron tomography and computational methods. The newly determined virus structure also serves as a model for the other bunyaviruses. Recent research surprisingly revealed that the viral membrane proteins protruding as spikes from the Uukuniemi virus surface changed their shape in an acidic environment. This phenomenon is reminiscent of the mechanism whereby influenza and dengue viruses enter their host cells. The observation helps to explain how bunyaviruses infect their host cells.

The Uukuniemi virus was first isolated in the village of Uukuniemi, Finland in the early 60s. Since then, it has proven to be an excellent model virus. Not being a human pathogen, the Uukuniemi virus is safe to work with, and yet it is very similar to many pathogenic bunyaviruses.

The Bunyaviridae viral family comprises more than 300 members and they are found worldwide. Many members of the family cause serious disease, such as hemorrhagic fever and encephalitis, for which no vaccines are available yet. Most of the bunyaviruses are transmitted by mosquitoes and ticks. The exception is hantaviruses, which belong to the Bunyaviridae family, and which are spread by voles and other rodents.


Contact: Dr. Juha Huiskonen
University of Helsinki

Related biology news :

1. Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
2. Poxvirus potency uncovered in new atomic map
3. Great apes endangered by human viruses
4. Ebola virus disarmed by excising a single gene
5. Penn researchers shine the light of venus to learn how the herpes virus invades cells
6. Yellowstone viruses jump between hot pools
7. Iowa State researchers develop technology for early detection of viruses
8. Study proposes new theory of how viruses may contribute to cancer
9. West Nile virus spread through nerve cells linked to serious complication
10. Feline virus, antiviral drug studied to understand drug resistance
11. The reservoir of Marburg virus identified in a species of fruit bat
Post Your Comments:
(Date:10/27/2015)... JOSE, Calif. , Oct. 27, 2015 Synaptics ... interface solutions, today announced that Google has adopted the ... of touch controller solutions to power its newest flagship ... 6P by Huawei. --> ... partners like Google to provide strategic collaboration in the ...
(Date:10/26/2015)... and LAS VEGAS , ... Nok Labs , an innovator in modern authentication and ... today announced the launch of its latest version of ... platform enabling organizations to use standards-based authentication that supports ... Nok S3 Authentication Suite is ideal for organizations deploying ...
(Date:10/23/2015)... 2015 Research and Markets ( ) ... Recognition Biometrics Market 2015-2019" report to their offering. ... The global voice recognition biometrics market to grow at ... --> --> The report, Global ... on an in-depth market analysis with inputs from industry ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 25, 2015 The Global ... a professional and in-depth study on the current ... (Logo: ) , The ... including definitions, classifications, applications and industry chain structure. ... international markets including development trends, competitive landscape analysis, ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be ... York on Wednesday, December 2 at 9:30 a.m. ET/6:30 ... CEO, will provide a corporate overview. th Annual ... 1:00 p.m. ET/10:00 a.m. PT . Jim Mazzola , ... corporate overview. --> th Annual Oppenheimer Healthcare Conference ...
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide provider ... , today announced that the company has set a new ... 391% quarter on quarter growth posted for Q3 of 2014 to ... and Mexico , with the establishment of an ... 2015. --> United Kingdom and ...
(Date:11/24/2015)... 2015 --> ... released by Transparency Market Research, the global non-invasive prenatal ... of 17.5% during the period between 2014 and 2022. ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... market to reach a valuation of US$2.38 bn by ...
Breaking Biology Technology: