Navigation Links
The Journal of Biological Chemistry commemorates an important 1987 discovery
Date:11/19/2012

It has been 25 years since the identification of two proteins that facilitate communication between nerve cells a significant achievement that revealed a group of related proteins. In recognition of this advancement, the Journal of Biological Chemistry has published a series of articles that assess what we know about each family member in this group and where that research is headed.

This superfamily was recognized in 1987 with the discoveries of the genes that encode two of its members, the GABAA and glycine receptors, and of the similarity of these proteins to the first characterized family of this group, nicotinic acetylcholine receptors. F. Anne Stephenson of the University College London School of Pharmacy, an author on one of the two 1987 articles, explains that these findings, in addition to revealing the new superfamily, led to the discovery of multiple protein subtypes within each family. Since that time, two other protein families have been added to the group the serotonin-3 receptors and the glutamate-gated chloride ion channels.

Proteins in this group, known as the cys-loop ligand-gated ion channel superfamily, are targeted by specific biological molecules (neurotransmitters) to allow the passage of ions across cell barriers, ultimately affecting functions such as muscle contraction, anxiety, pain, vision and food digestion and passage. For example, mutations in GABAA receptor subunits are involved in some forms of epilepsy. Also, certain anti-anxiety drugs target these receptors, and drugs that affect serotonin-3 receptors treat the nausea and vomiting associated with chemotherapy and irritable bowel syndrome.

The JBC series chronicles the history of this field, highlighting the many advances scientists have made over the past 25 years. Each review focuses on a different member of the group, covering its structure, regulation and functions. The roles of some of these proteins in diseases
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
240-283-6600
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tips from the journal mBio
2. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
3. Flavor and the new Nordic cuisine: BioMed Centrals new scientific journal Flavor is launched
4. Elsevier launches new journal Algal Research
5. AGU journal highlights for March 29, 2012
6. AGU journal highlights for April 16, 2012
7. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
8. New journal on disruptive science and technology launched by Mary Ann Liebert Inc. publishers
9. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
10. Special issue of the EMBO Journal celebrates 30 years of Wnt research
11. New peer-reviewed journal on big data launching in Fall 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... team of University of Maryland physicists has published ... say make possible new nanostructures and nanotechnologies with ... quantum computing advances to new sensor development. , ... Nature Communications the Maryland scientists, primary discovery ... nanostructures that uses a connector, or "intermedium," nanoparticle ...
(Date:9/2/2014)... always true that digital distribution of media will ... means, at least when file sizes are large. ... in Yale,s Journal of Industrial Ecology ... for consoles such as PlayStation3. Researchers found that ... greenhouse gas emissions than game files downloaded over ...
(Date:9/2/2014)... study provides evidence that physical barriers formed ... argue that the same factor responsible for much ... also responsible for the linguistic diversity in the ... interaction between speech communities. Therefore, spatially isolated languages ... reduction of linguistic contact. , "Charles Darwin would ...
Breaking Biology News(10 mins):New synthesis method may shape future of nanostructures, clean energy 2New synthesis method may shape future of nanostructures, clean energy 3
... power of viruses is well documented in human history. ... the great Goliaths of human civilization, most famously in ... European conquest and settlement. In recent years, there ... effect of the pandemics in the Americas wasn,t confined ...
... information is a basic property of biological systems. Common ... Transmission of signals occurs at an even ... molecules, which bear a phosphate or a sulfate group. ... are of supreme importance, they have been extensively studied ...
... often focused on its potential effects on coral reefs, ... may be more significant, according to Donald Potts, a ... of California, Santa Cruz, and an expert in coral ... give an invited talk on "Geobiological Responses to Ocean ...
Cached Biology News:New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists 2New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists 3Sulfurous ping-pong in the urinary tract 2Sulfurous ping-pong in the urinary tract 3Ocean acidification could have broad effects on marine ecosystems 2
(Date:9/2/2014)... , Sept. 2, 2014 Orexigen Therapeutics, ... the U.S. Patent and Trademark Office (PTO) has issued ... being evaluated for weight loss. NB32 is a fixed-dose ... U.S. Patent No. 8,815,889 claims methods for ... bupropion. The patent expires in 2024. If NB32 is ...
(Date:9/2/2014)... September 02, 2014 PMG Research, ... 11th clinical research site: PMG Research of Rocky Mount. ... operation of the clinical research department at Boice-Willis ... presence in eastern North Carolina. This new site enhances ... patients in Rocky Mount and the surrounding communities, this ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... $1,712.1 million by 2019 from $1,070.7 million in ... 2014 to 2019. The global oligonucleotide synthesis market ... services, applications, end users, and geography. The synthesized ... growth rate in the oligonucleotide synthesis market during ...
(Date:8/31/2014)... 2014 This is a professional ... the Epoxy Hardener industry in Global and ... the industry, including definitions, applications and industry chain ... analysis are provided with a focus on history, ... A comparison between the international and Chinese situation ...
Breaking Biology Technology:Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 4PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... , , ... pesticide residues in food and environmental samples requires the use ... technologies. In this , application note the benefits ... is described. In particular the role of the collision cell in the MS/MS , ...
... This paper addresses managers in different industries and describes the ... increases productivity, and touches upon subjects such as ease of use, ... also describes the main criteria managers should consider when choosing the ... Table of Contents: , ...
... by Erwin Hauser, Chief Engineer, KNF Neuberger, ... Introduction , ... drying operations, condensate may collect in the vacuum pump head. Consequently, the ... evacuate the designated volume. New, self-drying pumps clear moisture from the ...
Cached Biology Technology:Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 2Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 3Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 4Increase Your Organizations Productivity with LabVIEW 2Increase Your Organizations Productivity with LabVIEW 3Increase Your Organizations Productivity with LabVIEW 4Increase Your Organizations Productivity with LabVIEW 5Increase Your Organizations Productivity with LabVIEW 6Increase Your Organizations Productivity with LabVIEW 7Increase Your Organizations Productivity with LabVIEW 8Increase Your Organizations Productivity with LabVIEW 9Increase Your Organizations Productivity with LabVIEW 10Increase Your Organizations Productivity with LabVIEW 11Increase Your Organizations Productivity with LabVIEW 12Increase Your Organizations Productivity with LabVIEW 13Increase Your Organizations Productivity with LabVIEW 14Increase Your Organizations Productivity with LabVIEW 15Increase Your Organizations Productivity with LabVIEW 16Self-Drying Vacuum Pumps... the solution for applications producing condensation 2Self-Drying Vacuum Pumps... the solution for applications producing condensation 3Self-Drying Vacuum Pumps... the solution for applications producing condensation 4
... Disposable. Virgin, optically clear polystyrene with ... alphanumeric coordinates for cell counting. 100% ... is a new product number, created ... If showing no availability yet, please ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Mfr ...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
From formula-fed bovine calves Sterile, Cell culture tested...
Biology Products: