Navigation Links
The Journal of Biological Chemistry commemorates an important 1987 discovery
Date:11/19/2012

It has been 25 years since the identification of two proteins that facilitate communication between nerve cells a significant achievement that revealed a group of related proteins. In recognition of this advancement, the Journal of Biological Chemistry has published a series of articles that assess what we know about each family member in this group and where that research is headed.

This superfamily was recognized in 1987 with the discoveries of the genes that encode two of its members, the GABAA and glycine receptors, and of the similarity of these proteins to the first characterized family of this group, nicotinic acetylcholine receptors. F. Anne Stephenson of the University College London School of Pharmacy, an author on one of the two 1987 articles, explains that these findings, in addition to revealing the new superfamily, led to the discovery of multiple protein subtypes within each family. Since that time, two other protein families have been added to the group the serotonin-3 receptors and the glutamate-gated chloride ion channels.

Proteins in this group, known as the cys-loop ligand-gated ion channel superfamily, are targeted by specific biological molecules (neurotransmitters) to allow the passage of ions across cell barriers, ultimately affecting functions such as muscle contraction, anxiety, pain, vision and food digestion and passage. For example, mutations in GABAA receptor subunits are involved in some forms of epilepsy. Also, certain anti-anxiety drugs target these receptors, and drugs that affect serotonin-3 receptors treat the nausea and vomiting associated with chemotherapy and irritable bowel syndrome.

The JBC series chronicles the history of this field, highlighting the many advances scientists have made over the past 25 years. Each review focuses on a different member of the group, covering its structure, regulation and functions. The roles of some of these proteins in diseases and therapeutics are also discussed.

Since 1987, scientists have overcome major challenges and learned where particular protein subtypes of a family are located and what functions they perform. Stephenson emphasizes that the advancements in this field were a boost for the pharmaceutical industry in terms of finding selective drugs that lack undesirable side effects, such as nonsedating anti-anxiety drugs.

The JBC series was convened by Stephenson, who today is an associate editor of the journal and whose lab continues to investigate the structures and functions of neurotransmitter receptors, including the GABAA receptors, in health and disease.


'/>"/>
Contact: Angela Hopp
ahopp@asbmb.org
240-283-6600
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Tips from the journal mBio
2. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
3. Flavor and the new Nordic cuisine: BioMed Centrals new scientific journal Flavor is launched
4. Elsevier launches new journal Algal Research
5. AGU journal highlights for March 29, 2012
6. AGU journal highlights for April 16, 2012
7. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
8. New journal on disruptive science and technology launched by Mary Ann Liebert Inc. publishers
9. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
10. Special issue of the EMBO Journal celebrates 30 years of Wnt research
11. New peer-reviewed journal on big data launching in Fall 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The ... transformative for performing systematic gain-of-function studies. , This complement to loss-of-function studies, ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and ... San Diego Rotary Club. The event entitled “Stem Cells and Their ... 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter ...
Breaking Biology Technology: