Navigation Links
The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Date:3/18/2012

Microglia are the first line defence of the brain and are constantly looking for infections to fight off. Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage. New research published in BioMed Central's open access journal Journal of Neuroinflammation shows that, honokiol (HNK) is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to regulate DNA.

Scientists from the National Brain Research Centre, Manesar, India, used lipopolysaccharide (LPS), a molecule present on the surface of bacteria, to stimulate an immune response from microglia cells. LPS mimics the effect of a bacterial infection and the microglia cells spring into action, releasing proinflammatory cytokines, such as TNFa.

Activation of microglia also stimulates the production of nitric oxide (NO) and Cox-2, which co-ordinate the immune response, leading to inflammation. However uncontrolled inflammation can lead to neuronal death and permanent brain damage. Microglial inflammation is also observed in several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

The team led by Dr Anirban Basu found that the inflammatory response was mediated by Klf4, a 'transcription' factor which binds directly to DNA to enhance or impede gene expression. Treating microglia with HNK reduced their activation and HNK treated cells secreted less cytokines in response to LPS. HNK also down regulated the activity of Klf4 (and pNF-kb - another regulator of inflammation).

Dr Basu suggested that HNK down regulates Klf4 which in turn down regulates NO and Cox-2 production. He said, "HNK can easily move across the blood brain barrier and we found that HNK reduced levels of pNF-kb and Klf4 as well as the number of activated microglia in the brains of LPS treated mice."

He
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Springer and Japanese Society of Biorheology to work together
2. Geraniums could help control devastating Japanese beetle
3. Japanese gourmet mushroom found in Sweden
4. UCLA, Japanese company to collaborate on specialized nano-imaging instrumentation
5. Japanese researchers report on liver transplantation studies using animal and iPS cells
6. Moessbauer group of Mainz University preparing for participation in Japanese moon mission
7. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
8. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
9. Balance between traditional activities, tourism key to sustaining coastal Alaska communities
10. Traditional Dutch landscape under threat
11. Stroke Belt deaths tied to non-traditional risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... , May 21, 2015 The Sync ... of music for health, today announced a collaborative partnership ... The partnership will center on collaboration on original research, ... first step in the collaboration, The Sync Project and ... "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... LLC, a company engaged in biometric identification is an ... portion of the recently awarded TIES (Technical Information Engineering ... Army. 3D-ID LLC has a suite of ... and security agencies. Gino Pereira , ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... report released today by the University of Victoria ranks ... to the environment. It is the first study to ... unlabeled options in the marketplace. "How Green ... sort through competing sustainability claims and better identify those ...
... bane of picky eaters everywhere, broccoli,s taste is not just ... easily taste a bitter compound in the vegetable that others ... helped uncover the evolutionary history of one of the genes ... the gene, the researchers discovered something unexpected: something other than ...
... of additional radioactive leaks from Fukushima nuclear power plants, ... from the plants remains unclear. But a new study ... radioactivity discharged from the facility in the first four ... about the history of contaminant releases to the ocean., ...
Cached Biology News:New study puts eco-labels to the test 2Penn geneticists help show bitter taste perception is not just about flavors 2Penn geneticists help show bitter taste perception is not just about flavors 3Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 2Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 3
(Date:5/21/2015)... YORK , May 21, 2015  Susan ... Research (FPWR), a nonprofit organization dedicated to supporting ... Prader-Willi syndrome (PWS), announced today that FPWR has ... and Irina Shaulov contributed $1 million ... clinical initiatives.  ...
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... 2015 Imagine being able to ... those of others. Being able to read faces and ... people to anticipate their thoughts and actions like never ... feelings to create unique abstract paintings and video, or, ... inside a first-person-shooter as it creates action, dialog, and ...
(Date:5/21/2015)... NJ (PRWEB) May 21, 2015 Patent ... a method for diagnostic or therapeutic imaging within a ... apparatus uses an endoscope having a low cost, single-use ... USPTO filing date was October 18, 2013 and the ... The technology enables the physician to customize the lighting ...
Breaking Biology Technology:The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 35 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... 2011  MacroGenics, Inc., a privately held biotechnology company ... that it will receive a milestone payment from ... part of an agreement executed in October 2010 ... on MacroGenics, Dual-Affinity Re-Targeting (DART) platform.  The amount ...
... in everyday materials, polymers and the field of ... U.S. economy. Polymers possess unique properties and processing ... For these reasons, advances in polymer science ... 21st century challenges of energy, sustainability, clean water, ...
... /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: CO ) ... blood banking operator in China, today announced the results of ... 19, 2011, in Hong Kong. At the Annual ... and Dr. Yungang (Ken) Lu to serve on the Board ...
Cached Biology Technology:MacroGenics Receives Milestone Payment as Part of Its Global DART™ Alliance with Boehringer Ingelheim 2Research and education success earns more NSF funding 2Research and education success earns more NSF funding 3China Cord Blood Corporation Announces Results of 2011 Annual General Meeting 2
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
Biology Products: