Navigation Links
The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Date:3/18/2012

Microglia are the first line defence of the brain and are constantly looking for infections to fight off. Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage. New research published in BioMed Central's open access journal Journal of Neuroinflammation shows that, honokiol (HNK) is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to regulate DNA.

Scientists from the National Brain Research Centre, Manesar, India, used lipopolysaccharide (LPS), a molecule present on the surface of bacteria, to stimulate an immune response from microglia cells. LPS mimics the effect of a bacterial infection and the microglia cells spring into action, releasing proinflammatory cytokines, such as TNFa.

Activation of microglia also stimulates the production of nitric oxide (NO) and Cox-2, which co-ordinate the immune response, leading to inflammation. However uncontrolled inflammation can lead to neuronal death and permanent brain damage. Microglial inflammation is also observed in several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

The team led by Dr Anirban Basu found that the inflammatory response was mediated by Klf4, a 'transcription' factor which binds directly to DNA to enhance or impede gene expression. Treating microglia with HNK reduced their activation and HNK treated cells secreted less cytokines in response to LPS. HNK also down regulated the activity of Klf4 (and pNF-kb - another regulator of inflammation).

Dr Basu suggested that HNK down regulates Klf4 which in turn down regulates NO and Cox-2 production. He said, "HNK can easily move across the blood brain barrier and we found that HNK reduced levels of pNF-kb and Klf4 as well as the number of activated microglia in the brains of LPS treated mice."

He continued, "Our work with HNK has found that Klf4 is an important regulator of inflammation. Both HNK and Klf4 may be important not only in regulating inflammation due to infection, but may also have applications in other diseases which affect the brain and nervous system."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related biology news :

1. Springer and Japanese Society of Biorheology to work together
2. Geraniums could help control devastating Japanese beetle
3. Japanese gourmet mushroom found in Sweden
4. UCLA, Japanese company to collaborate on specialized nano-imaging instrumentation
5. Japanese researchers report on liver transplantation studies using animal and iPS cells
6. Moessbauer group of Mainz University preparing for participation in Japanese moon mission
7. Genome-wide study reveals 3 new susceptibility loci for adult asthma in Japanese population
8. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
9. Balance between traditional activities, tourism key to sustaining coastal Alaska communities
10. Traditional Dutch landscape under threat
11. Stroke Belt deaths tied to non-traditional risk factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... -- ... Research and Markets has announced the addition of the "Global Military ... report forecasts the global military biometrics market to grow at a CAGR ... been prepared based on an in-depth market analysis with inputs from industry ... the coming years. The report also includes a discussion of the key ...
(Date:12/12/2016)... 12, 2016  Researchers at Trinity College, Dublin, ... by combining the material with Silly Putty. The mixture ... detector able to sense pulse, blood pressure, respiration, ... The research team,s findings were ... here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... 2016 BioCatch , the global leader in ... portfolio, which grew to over 40 granted and pending patents. ... , , The ... " System, Device, and Method Estimating Force Applied to a ... to forego costly hardware components needed to estimate the force and pressure ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... 2017 Roka Bioscience, Inc. (NASDAQ: ROKA ), ... the detection of foodborne pathogens today announced the appointment of ... Paul Thomas , the Company,s President and CEO since 2009, who ... Directors.  The changes are effective today. In addition, Ms. ... ...
(Date:1/17/2017)... , Jan. 17, 2017 Noom ... is the first to offer fully Spanish behavior ... Noom,s Spanish diabetes prevention and healthy ... and accessibility of lifestyle interventions among Hispanic Americans ... conditions. Noom,s robust food database, program-specific curriculum content ...
(Date:1/17/2017)... 17, 2017  Northwell Health today announced a ... precision cancer research. As ... care provider, Northwell Health diagnoses and treats 19,000 ... a Germany -based oncology research ... they will greatly expand cancer biobanking activities within ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... re-engineered Drug Safety Technology Consortium™ (SafeTEC™), $3 million in investment towards 15+ TEC ... new tools and assays, and their applicability in drug safety assessment, for the ...
Breaking Biology Technology: