The researchers studied the immune response of 107 pregnant women after they were injected with a single dose of non-adjuvant H1N1 vaccine. They concluded that the influenza shot boosted the immune response in pregnant women and at the same time protected neuronatal babies via the antibodies that transferred through the placenta.
These results were published in the review Annals of Internal Medicine dated December 6th,.2011. They are available on-line at: http://www.annals.org/content/155/11/733.abstract
Influenza (the flu) is a contagious, acute respiratory infection caused by the family of viruses Influenzae. There are three types of Influenza virus: A, B and C. The A and B viruses cause seasonal (or winter) epidemics, but only the A virus is responsible for worldwide epidemics. Very soon into the worldwide influenza epidemic of 2009, pregnant women and neonatal babies were found to be at very high risk of complications and death if infected, as had already been observed during previous worldwide influenza epidemics. As early as August 2009, a study published in The Lancet showed that 10% of the serious cases were observed in pregnant women, whereas they represented only 1% of the total French population. So H1N1 influenza vaccination of pregnant women was recommended as a priority.
The team led by Odile Launey, the Director of vaccinology at the Centre for Clinical Investigation at Cochin Pasteur (Inserm/AP-HP/Institut Pasteur/Universit Paris Descartes), carried out a vaccination study in order to demonstrate the immunogenicity, in other words the immune response in terms of the production of antibodies, after a single injection of a nonadjuvant A strain (H1N1) into women at 21 days and 42 days of gestation and to measure the transplacentary transfer of the mother's antibodies to neonatal babies.
This study concerned 107 women between 22 and 32 weeks of
|Contact: Inserm Presse|
INSERM (Institut national de la sant et de la recherche mdicale)