Navigation Links
The ENCODE Project publishes new genomic insights in special issue of Genome Research
Date:9/5/2012

ommunity resources.

Also in this issue are detailed reports of experimental validations to complement the GENCODE gene data and novel strategies for further annotating the genome. Howald and colleagues developed the RT-PCR-seq method to show that a substantial portion of exons, the protein-coding regions of genes retained by splicing, are not well annotated by unbiased RNA-sequencing alone, requiring a more targeted strategy in combination.

GENCODE has mapped more than 9,500 long non-coding RNA (lncRNAs), but up until now, only about 100 have been characterized with cellular function. lncRNAs, which are transcribed in a range of human tissues and play roles in gene regulation, are particularly interesting because they do not seem to be as well-conserved evolutionarily, in contrast to conservation of genes that code for proteins. Derrien et al. have analyzed the GENCODE lncRNA annotations, integrating the lncRNA data with other ENCODE transcriptome and epigenome data, presenting the most comprehensive lncRNA annotation to date. The authors show that approximately one-third of lncRNAs have arisen in the primate lineage, suggesting that there may be important lncRNA functions yet to be discovered.

References:

  • Harrow et al., GENCODE: The reference human genome annotation for The ENCODE Project. Genome Res doi: 10.1101/gr.135350.111
  • Howald et al., Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome. Genome Res doi: 10.1101/gr.134478.111
  • Derrien et al., The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res doi: 10.1101/gr.132159.111

2. ENCODE studies clarify the murky world of RNAs

The ENCODE Project's efforts to annotate the genome include the sequencing of RNA, the message transcribed from DNA to code for proteins and perform other cellular
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. University of Alberta led research may have discovered how memories are encoded in our brains
2. Concern about plans to close unique Canadian environmental project
3. Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015
4. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
5. New book tells story of 10-year-old malaria project
6. WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs
7. UD partner in NIH research project to produce artificial salivary glands
8. New UC Santa Barbara-based project to study contaminants in urban water environment
9. First Indian-European research networking projects in the social sciences launched
10. UTMB scientists awarded NIH grant for lab-grown lung tissue project
11. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
(Date:9/16/2014)... salmon-rich waters of Southeast Alaska to the white sand ... lumber and tourist towns, coastal residents around the U.S. ... divide along political lines. That,s a primary finding of ... published this month in the journal Society & ... environment-related differences from place to place to place. Each ...
(Date:9/16/2014)... functions in an organism. For example, they catalyze ... control immune system responses. Researchers established some years ... each other, but instead form complex networks. , ... many similarities with online social networks," says Dr. ... Biology. "Some proteins are good networkers that maintain ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Good networkers make prime targets 2
... 10, 2009If you are spending the holidays with big Uncle ... be better off with another family, spare a thought for ... McMaster University and the University of New South Wales has ... members make strategic decisions about their living situation. ...
... tool use as a defining feature of humans. That,s until ... with birds and an array of other mammals. Now, a ... , a Cell Press publication, adds an octopus to the ... study manages a behavioral trick that the researchers call stilt ...
... Dec. 14 MODA Technology Partners, a global software ... testing for the Pharmaceutical industry, today announced the general ... data acquisition platform. The latest release enables quality control ... , MODA 3.0 includes the following new capabilities: ...
Cached Biology News:Tool use in an invertebrate: The coconut-carrying octopus 2MODA Announces Availability of Third Generation Mobile Data Acquisition Platform 2
(Date:9/15/2014)... State University have developed a technique for controlling the ... voltages, opening the door to a new generation of ... hinges on the fact that the oxide "skin" of ... acts as a surfactant, lowering the surface tension ... researchers used a liquid metal alloy of gallium and ...
(Date:9/15/2014)... 2014 Zymo Research Corp., has announced the ... safe ambient temperature storage and transport of infectious ... of agents in such samples is completely inactivated ... the viral nucleic acids for subsequent analyses.  With ... in West Africa and ...
(Date:9/15/2014)... September 2014 Die zweite jährliche ... 12. bis 18. Oktober stattfinden. Die IPAW ist ... Association (PPTA) und ihrer Mitgliedsunternehmen ... globale Bewusstsein für die Gewinnung von Quellplasma zu ... Retten und Verbessern von Leben zu würdigen ...
(Date:9/14/2014)... Baltimore, MD (PRWEB) September 15, 2014 ... will be held on Tuesday, October 21, 2014, from ... an overview of the program’s innovative curriculum and practice-oriented ... how a graduate degree can help advance their career ... please RSVP online . , About UMBC’s ...
Breaking Biology Technology:Researchers control surface tension to manipulate liquid metals 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2
... Encorium Group, Inc. (Nasdaq:  ENCO), (the "Company"), ... conducting studies in over 30 countries for many ... today announced that, on October 20, 2010, it ... (the "Panel") has determined to delist the Company,s ...
... available in German . Jena (21 ... in improving a fabrication process for Atomic Force Microscopy (AFM) ... scan surfaces so that even tiniest nano structures become visible. ... development of new materials and carrier systems for active substances. ...
... Transgenomic, Inc. (OTC Bulletin Board: TBIO ) ... company as Medical Director for Laboratory Services.  In this ... leading the strategic vision and managing the day-to-day operations ... Dr. Johnson brings to Transgenomic nearly 20 years of ...
Cached Biology Technology:Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 2Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 3Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 4AFM tips from the microwave 2Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 2Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 3Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 4
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (C6671) or contact ... treated yes Surface area 148 cm ...
... System is intended for use in the ... an in-house validated in vitro nucleic acid ... • The CHEMICON ... capture assay designed to detect amplified nucleic ...
... PhageMaker System is optimized for maximum packaging efficiencies ... any bacteriophage l vector. Using a test insert ... pfu/g arms (> 4 x 10^8 pfu/g ligated ... system is extremely easy to use; simply add ...
BD BioCoat Laminin 150 mm Culture Dishes...
Biology Products: