Navigation Links
The ENCODE Project publishes new genomic insights in special issue of Genome Research
Date:9/5/2012

ommunity resources.

Also in this issue are detailed reports of experimental validations to complement the GENCODE gene data and novel strategies for further annotating the genome. Howald and colleagues developed the RT-PCR-seq method to show that a substantial portion of exons, the protein-coding regions of genes retained by splicing, are not well annotated by unbiased RNA-sequencing alone, requiring a more targeted strategy in combination.

GENCODE has mapped more than 9,500 long non-coding RNA (lncRNAs), but up until now, only about 100 have been characterized with cellular function. lncRNAs, which are transcribed in a range of human tissues and play roles in gene regulation, are particularly interesting because they do not seem to be as well-conserved evolutionarily, in contrast to conservation of genes that code for proteins. Derrien et al. have analyzed the GENCODE lncRNA annotations, integrating the lncRNA data with other ENCODE transcriptome and epigenome data, presenting the most comprehensive lncRNA annotation to date. The authors show that approximately one-third of lncRNAs have arisen in the primate lineage, suggesting that there may be important lncRNA functions yet to be discovered.

References:

  • Harrow et al., GENCODE: The reference human genome annotation for The ENCODE Project. Genome Res doi: 10.1101/gr.135350.111
  • Howald et al., Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome. Genome Res doi: 10.1101/gr.134478.111
  • Derrien et al., The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res doi: 10.1101/gr.132159.111

2. ENCODE studies clarify the murky world of RNAs

The ENCODE Project's efforts to annotate the genome include the sequencing of RNA, the message transcribed from DNA to code for proteins and perform other cellular
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6

Related biology news :

1. University of Alberta led research may have discovered how memories are encoded in our brains
2. Concern about plans to close unique Canadian environmental project
3. Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015
4. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
5. New book tells story of 10-year-old malaria project
6. WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs
7. UD partner in NIH research project to produce artificial salivary glands
8. New UC Santa Barbara-based project to study contaminants in urban water environment
9. First Indian-European research networking projects in the social sciences launched
10. UTMB scientists awarded NIH grant for lab-grown lung tissue project
11. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... Jersey, and City University of New York have invented ... effectively clears organisms to be viewed under microscopes. Visikol ... is one of the few high-quality clearing solutions currently ... Enforcement Administration (DEA) due to its use as a ... for viewing organisms under a microscope. Without them, microscope ...
(Date:5/17/2013)... Shenzhen, China---- Why Tibetan antelope can live at ... a collaborative research published in Nature Communications ... institutes provide evidence that some genetic factors may ... highland environments. The data in this work will ... and the biology of other ruminant species. , ...
(Date:5/17/2013)... American Societies for Experimental Biology (FASEB) released a new ... funding trends highlighting the devastating impact of sequestration on ... analysis follows a May 15th Senate Appropriations Committee hearing ... that the $1.6 billion cut the agency sustained in ... impact on the scientific community." , According to ...
Breaking Biology News(10 mins):New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2
... Leading experts from the European Society on Clinical ... and the International Osteoporosis Foundation (IOF) have published ... subtrochanteric femoral (upper thigh bone) fractures and long-term ... most common drug therapy for osteoporotic fracture prevention, ...
... a warmer world? UCLA life scientists present new evidence that ... polar bears lose habitat due to global warming, these biologists ... sources of food, where they will increasingly come into competition ... competition might unfold, the UCLA biologists constructed three-dimensional computer models ...
... This Thanksgiving, when you bite into the cranberry sauce and ... comment from your sister, consider the power of sour.,Neurobiology researchers ... discovery about how some cells respond to sour tastes. ... and umami sour is arguably the strongest yet the ...
Cached Biology News:IOF and ESCEO position on atypical femoral fractures and long-term bisphosphonate use 2Biologists report more bad news for polar bears 2Biologists report more bad news for polar bears 3Biologists report more bad news for polar bears 4Sour research, sweet results 2
(Date:5/21/2013)... (PRWEB) May 21, 2013 The Formulate ... display solution for sales and marketing teams looking for a ... describes the kit as “everything you’ll need to put together ... Display Kit comes with a number of displays and accessories ... booth 20 feet by 20 feet in size. These components ...
(Date:5/20/2013)... 20, 2013 Oven Industries Inc. announces ... capabilities. The 5R6-900 benchtop controller has many outstanding user-friendly ... be plugged into the wall as a self-contained temperature ... distinctive detail makes the device unique, as well as ... temperature controller can also be used universally, which allows ...
(Date:5/20/2013)...  Dr. Gerald Zon , noted ... launched a new blog in conjunction with TriLink BioTechnologies. ... focuses on what,s trending in the field of nucleic ... discussions of research presented at conferences and meetings, reviews ... Zon (PhD Princeton University 1971) developed automated synthesis of ...
(Date:5/20/2013)... , May 20, 2013 Cempra, ... on developing differentiated antibiotics to meet critical medical ... announced that it presented data at the American ... Philadelphia demonstrating the antibacterial and ... Cempra,s prior Phase 2 clinical trial in outpatients ...
Breaking Biology Technology:GLM Displays Announces All-in-One Formulate Fusion Fabric Display Kit 2New Laboratory Temperature Controller by Oven Industries 2Dr. Gerald 'Jerry' Zon Launches New Blog for TriLink BioTechnologies 2Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP) 2
... could be the basis of a new type of solar ... "We expect these structures will allow us to make better, ... investigator on the $100,000 grant. Fractals are patterns that ... silver 1-50th the width of a human hair are themselves ...
... American Botanical Council has announced that Bioforce AG is ... Investment in Phytomedicinal Research Award. Bioforce AG is a ... on pharmacological and clinical research each year, according to ... "We were surprised and honored to receive ...
... the difference between salt water and fresh water is ... ammonium bicarbonate salt solution, Penn State researchers can combine ... the salt-water fresh-water gradient to produce power anywhere. ... putting them together," said Bruce E. Logan, Kappe Professor ...
Cached Biology Technology:Bioforce Receives American Botanical Council's Tyler Award 2Bioforce Receives American Botanical Council's Tyler Award 3Bioforce Receives American Botanical Council's Tyler Award 4Bioforce Receives American Botanical Council's Tyler Award 5Unique salt allows energy production to move inland 2
...
...
Mouse monoclonal antibody raised against a partial recombinant ALAS2. NCBI Entrez Gene ID = ALAS2...
Mouse monoclonal antibody raised against a partial recombinant QPCT. NCBI Entrez Gene ID = QPCT...
Biology Products: