Navigation Links
The ENCODE Project publishes new genomic insights in special issue of Genome Research
Date:9/5/2012

ommunity resources.

Also in this issue are detailed reports of experimental validations to complement the GENCODE gene data and novel strategies for further annotating the genome. Howald and colleagues developed the RT-PCR-seq method to show that a substantial portion of exons, the protein-coding regions of genes retained by splicing, are not well annotated by unbiased RNA-sequencing alone, requiring a more targeted strategy in combination.

GENCODE has mapped more than 9,500 long non-coding RNA (lncRNAs), but up until now, only about 100 have been characterized with cellular function. lncRNAs, which are transcribed in a range of human tissues and play roles in gene regulation, are particularly interesting because they do not seem to be as well-conserved evolutionarily, in contrast to conservation of genes that code for proteins. Derrien et al. have analyzed the GENCODE lncRNA annotations, integrating the lncRNA data with other ENCODE transcriptome and epigenome data, presenting the most comprehensive lncRNA annotation to date. The authors show that approximately one-third of lncRNAs have arisen in the primate lineage, suggesting that there may be important lncRNA functions yet to be discovered.

References:

  • Harrow et al., GENCODE: The reference human genome annotation for The ENCODE Project. Genome Res doi: 10.1101/gr.135350.111
  • Howald et al., Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome. Genome Res doi: 10.1101/gr.134478.111
  • Derrien et al., The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res doi: 10.1101/gr.132159.111

2. ENCODE studies clarify the murky world of RNAs

The ENCODE Project's efforts to annotate the genome include the sequencing of RNA, the message transcribed from DNA to code for proteins and perform other cellular
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. University of Alberta led research may have discovered how memories are encoded in our brains
2. Concern about plans to close unique Canadian environmental project
3. Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015
4. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
5. New book tells story of 10-year-old malaria project
6. WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs
7. UD partner in NIH research project to produce artificial salivary glands
8. New UC Santa Barbara-based project to study contaminants in urban water environment
9. First Indian-European research networking projects in the social sciences launched
10. UTMB scientists awarded NIH grant for lab-grown lung tissue project
11. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
(Date:12/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ... "Biometrics Market in Japan 2014-2018" report to ... The integration of biometrics and ... and upgradation of the driver,s license is one ... Besides the aforementioned projects, biometrics is being used ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... linked to many of the same health problems as tobacco ... wheeze, according to a new study by researchers at Yale ... used illicit drug in the United States, and abuse of ... in today's Archives of Internal Medicine. First author Jeanette M. ...
... of the same health problems as tobacco smoke, such as ... a new study by researchers at Yale School of Medicine. ... in the United States, and abuse of the drug is ... of Internal Medicine. First author Jeanette M. Tetrault, M.D., and ...
... has long been recognized that birds possess the ability to ... how this is done has not yet been clarified. ... homing pigeons in a new study (1) by Gerta Fleissner ... promising insight into this complex topic. The article will ...
Cached Biology News:Migration played key role in HIV spread in South Africa 2Long-term marijuana smoking leads to respiratory complaints 2Homing pigeons get their bearings from their beaks 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the ... Maroulis, Pharm.D. to the newly created position of Vice ... position, Dr. Maroulis will continue to manage the entire ... multi-site pharmacies as the company expands. Dr. Maroulis has ... he has served in many different capacities in the ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014  Roche (SIX: ... of Bina Technologies, Inc. (Bina), a privately held ... , USA. Bina provides a big data ... generation sequencing (NGS) data. Bina,s proprietary on-market Genomic ... and academic researchers to perform fast and scalable ...
(Date:12/19/2014)... Decision Resources Group finds that the Latin ... percent compound annual growth rate through 2023. This is ... the increasing adoption of dental implants. Growing aesthetic consciousness ... spur demand for dental biomaterials because they can improve ... Other key findings from Decision Resources Group,s ...
(Date:12/19/2014)... 18, 2014 BioPlus Specialty ... specialty pharmacies, has an expanded team of Regional ... consultants for prescriber offices in their regions, with ... “We have a variety of Regional Pharmaceutical Care ... specializing in hepatitis C help prescribers understand all ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3
... US Oncology, Inc ., the nation,s ... treatment and research network in the United States, ... quarter of fiscal 2010 on Thursday, Nov. 4. ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20100517/DA06089LOGO ) A conference ...
... HONG KONG, Oct. 7 /PRNewswire-Asia-FirstCall/ -- China Cord ... CO ), the first and largest cord blood ... authorization of the stock repurchase program on September 15, ... for approximately US$1.6 million through October 6, 2010 at ...
... Dendreon Corporation (Nasdaq: DNDN ) today announced ... 3, 2010 at 4:30 p.m. ET to review third quarter ... be obtained as follows: Time: , 4:30 PM ... 2010Dial-in: , 1-866-730-5769 (domestic) or +1-857-350-1593 (international); conference ...
Cached Biology Technology:US Oncology to Report 2010 Third Quarter Operating Results 2China Cord Blood Corporation Updates Status Regarding Share Repurchase Program 2Dendreon to Host Conference Call on November 3rd to Announce Third Quarter Financial Results 2
Request Info...
... RNA polymerase is a DNA-dependent RNA polymerase ... promoters. It efficiently synthesizes in vitro ... down stream from a T7 promoter. ... templates for in vitro translation, substrates in ...
... yeast/leuconostoc overproducer ATP: D-hexose 6- ... One unit of HK will ... in 1 min at 25C ... of G6P-DH will oxidize 1 ...
... H degrades, as an endoribonuclease, the ... hybrids of natural origin, e.g. that ... complexes, e.g. poly(A) x poly(dT). RNase ... 3-OH termini. Nearly no activity is ...
Biology Products: