Navigation Links
The ENCODE Project publishes new genomic insights in special issue of Genome Research
Date:9/5/2012

ommunity resources.

Also in this issue are detailed reports of experimental validations to complement the GENCODE gene data and novel strategies for further annotating the genome. Howald and colleagues developed the RT-PCR-seq method to show that a substantial portion of exons, the protein-coding regions of genes retained by splicing, are not well annotated by unbiased RNA-sequencing alone, requiring a more targeted strategy in combination.

GENCODE has mapped more than 9,500 long non-coding RNA (lncRNAs), but up until now, only about 100 have been characterized with cellular function. lncRNAs, which are transcribed in a range of human tissues and play roles in gene regulation, are particularly interesting because they do not seem to be as well-conserved evolutionarily, in contrast to conservation of genes that code for proteins. Derrien et al. have analyzed the GENCODE lncRNA annotations, integrating the lncRNA data with other ENCODE transcriptome and epigenome data, presenting the most comprehensive lncRNA annotation to date. The authors show that approximately one-third of lncRNAs have arisen in the primate lineage, suggesting that there may be important lncRNA functions yet to be discovered.

References:

  • Harrow et al., GENCODE: The reference human genome annotation for The ENCODE Project. Genome Res doi: 10.1101/gr.135350.111
  • Howald et al., Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome. Genome Res doi: 10.1101/gr.134478.111
  • Derrien et al., The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res doi: 10.1101/gr.132159.111

2. ENCODE studies clarify the murky world of RNAs

The ENCODE Project's efforts to annotate the genome include the sequencing of RNA, the message transcribed from DNA to code for proteins and perform other cellular
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. University of Alberta led research may have discovered how memories are encoded in our brains
2. Concern about plans to close unique Canadian environmental project
3. Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015
4. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
5. New book tells story of 10-year-old malaria project
6. WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs
7. UD partner in NIH research project to produce artificial salivary glands
8. New UC Santa Barbara-based project to study contaminants in urban water environment
9. First Indian-European research networking projects in the social sciences launched
10. UTMB scientists awarded NIH grant for lab-grown lung tissue project
11. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... species may be able to cope with the rising salinity ... The Arctic today is best known for its tundra and ... 53 to 38 million years ago during what is known ... a huge temperate forest with brackish water, home to a ... crocodiles and giant tortoises. Much of what is known about ...
(Date:7/9/2014)... on the verge of an economy driven by methane, the ... and is undergoing a production boom. It has poised the ... is casting serious doubts over just how climate-friendly it is, ... (C&EN), the weekly news magazine of the American Chemical ... at C&EN, explains that when burned as a fuel to ...
(Date:7/9/2014)... N-methyl-D-aspartate receptor antagonists can alleviate the symptoms ... irreversible cognitive dysfunction and effectively scavenge amyloid ... peptide (Aβ) vaccines reduced and eliminated Aβ ... mouse model, and significantly improved behavioral and ... team, First Affiliated Hospital of China Medical ...
Breaking Biology News(10 mins):Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... break down plant biomass into the precursors of biodiesel or ... alternatives to petroleum. But the potential of this "biorefinery" technology ... down lignin, a highly stable polymer that makes up as ... bacteria are among few microorganisms known to degrade and ...
... early step toward new treatments for people with osteoporosis, scientists ... can help male mice produce healthier bones. Interestingly, the ... in the Journal of Cellular Physiology . "We ... though it,s unclear exactly why," said lead author Laura McCabe, ...
... release is available in Arabic , French, ... . Pharmaceutical drugs that end up in the ... plants may lead to unexpected ecological impacts, according to a new ... University in Sweden discovered that the fish ate faster, became bolder ...
Cached Biology News:A microbial biorefinery provides new insight into how bacteria regulate genes 2A microbial biorefinery provides new insight into how bacteria regulate genes 3Building healthy bones takes guts 2Mood-modifying drugs for humans also alter fish behavior 2Mood-modifying drugs for humans also alter fish behavior 3
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... conjugates for cancer, today announced the appointment of Thomas C ... has over 20 years, development experience gained in the biotechnology ... "I am delighted to welcome Tom at this ...
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... (Nasdaq: ITMN ) today announced the issuance of ... covers the ITMN-191 (R7227) compound. The nominal 20-year patent ... inhibitor of the hepatitis C virus (HCV) NS3/4A protease. ... said, "We are pleased to announce that this new patent, ...
... Human Genome Sciences, Inc. (Nasdaq: HGSI ... call to discuss its financial results for the year ... to be disclosed on Thursday, February 26, 2009, after ... conference call will be hosted by senior management and ...
... Advanced cholesterol test helps usher in new era of ... For the Pittsburgh Steelers, ... given them the boost to win Super Bowl XLIII. ... oils dramatically improve cholesterol levels in professional football players. ...
Cached Biology Technology:InterMune Announces Issuance of U.S. Patent for ITMN-191 2InterMune Announces Issuance of U.S. Patent for ITMN-191 3Human Genome Sciences to Sponsor Conference Call to Discuss Full Year 2008 Financial Results 2VAP Test Demonstrates Value of Fish Oil in Reducing Heart Risk for Super Bowl Champs 2VAP Test Demonstrates Value of Fish Oil in Reducing Heart Risk for Super Bowl Champs 3
... gasket slides/kit Gasket slide kit (1x 22K ... or Gasket slide kit ... disposable gasket slides offered in either 11K or 22K ... The gaskets are carefully fabricated and batch tested ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
... Oligo Microarray Kit (V2), 2 x ... characterize expression of many thousands of ... during important biological processes. Each microarray ... known ORFs from the S288C strain ...
Biology Products: