Genome Research publishes online and in print today a special issue dedicated to The ENCODE (ENCyclopedia Of DNA Elements) Project, whose goal is to characterize all functional elements in the human genome. Since the completion of the pilot phase of the project in 2007, covering 1% of the genome, The ENCODE Consortium has fanned out across the genome to study function and regulation on an unprecedented scale. This special issue presents novel findings, methodologies, and resources from ENCODE that bring extensive insight to gene regulation and set the stage for future discoveries. In addition, the issue also contains commentary and perspectives on how our views of the genome have changed as a result of The ENCODE Project. The entire issue will be freely available online on September 6 to coordinate with additional ENCODE Consortium publications in Nature, Genome Biology, and other journals.
1. GENCODE presents the most detailed annotation of the genome yet
From the completion of the pilot phase of The ENCODE Project in 2007, it has been evident that there is much more to a gene than the just a sequence that codes for protein, changing our concept of what defines a gene. We now know that the genome is not a set of discrete genes, but rather a complex system of genes and regulatory regions, much of which is transcribed into RNA, including many RNAs that do not code for protein but have critical cellular functions.
When The ENCODE Project was launched, a subgroup of the project called The GENCODE Consortium was established to accurately map and annotate these complex features across the human genome, by both manual curation and computational methods. In this special issue, Harrow and colleagues of The GENCODE Consortium present the latest release of GENOCDE gene data, describing a wealth of new information that exceeds the depth of annotation of other c
|Contact: Peggy Calicchia|
Cold Spring Harbor Laboratory