Navigation Links
The Burnham buzz
Date:12/8/2008

n: Designer Drugs to Block Breast Cancer

Gregory Roth, Ph.D., and colleagues have determined that a biologically active molecule called a chemokine promotes the spread of tumors, particularly in breast cancer. Dr. Roth believes that compounds that block the chemokine may be potential cancer therapies. However, existing small molecules that bind to chemokines only bind weakly, making them poor drug candidates. Dr. Roth and a team of Burnham chemists are working to custom-design molecules that bind tightly to the chemokine, hoping to block its activity and stop the spread of tumors.

Choking Out Cancer

Ze'ev Ronai, Ph.D. is trying to kill off cancer by choking it. When tumors are deprived of oxygen, they activate a transcription factor called HIF-1a that helps the tumor compensate and survive. Inhibiting HIF-1a has been hypothesized to be a means of defeating cancer, as tumors eventually experience oxygen deprivation due to insufficient blood flow to the tumor. Dr. Ronai's laboratory has demonstrated proof of this concept by inhibiting PHD3, a regulator of HIF-1a. Binding of short protein fragments to PHD3 results in HIF-1a degradation and halts growth of metastatic tumors in mice. Dr. Ronai's team is now investigating how small molecule compounds might accomplish the same thing.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Burnham researchers turn cancer friend into cancer foe
2. Burnham researcher awarded $8 million grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... microscopy revealed the presence of tiny blob-like structures that ... still don,t know what they do even though ... be crucial to the life of a cell, and ... In the Journal of Cell Biology , two ... backgrounds, from biophysics to cell biology, to focus their ...
(Date:8/31/2014)... sniffing the highly infectious bacteria C. diff , ... developed by a team at the University of Leicester. ... demonstrated that it is possible to identify the unique ... to rapid diagnosis of the condition., What is more, ... identify different strains of the disease simply from their ...
(Date:8/31/2014)... malaria diagnosis has changed very little. After taking a blood ... a glass slide, stains it with a special dye, and ... the disease. This approach gives an accurate count of how ... of disease severity but is not ideal because there ... the Singapore-MIT Alliance for Research and Technology (SMART) has now ...
Breaking Biology News(10 mins):Scientists call for investigation of mysterious cloud-like collections in cells 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2A new way to diagnose malaria 2A new way to diagnose malaria 3
... incurable disorder that results from the death of certain neurons ... behavior and movements. The neurodegenerative disease is caused by ... abnormal expansion in a part of DNA, called a CAG ... A healthy version of the Htt gene has between 20 ...
... NY, December 11, 2013 Mary Ann Liebert, Inc., publishers ... and Repositioning , a dynamic new peer-reviewed journal that ... for approved drugsparticularly for disorders where no animal model, ... identified. The Journal will be published online with open ...
... December 2013 Six life science researchers will receive ... the scientists to relocate and set up their research ... EMBO Installation Grants are awarded annually to strengthen science ... talented young group leaders in coming back to their ...
Cached Biology News:Staying ahead of Huntington's disease 2Drug Repurposing, Rescue, and Repositioning: A groundbreaking new journal from Mary Ann Liebert, Inc. 26 Installation Grants awarded 2
(Date:8/28/2014)... Sterlitech is proud to announce that it is ... of products . These additional products increase the ... filters with surface charges. , “We have ... membrane process testing equipment, and correspondingly, a wider demand ... Sterlitech President Mark Spatz. “The addition of Synder ...
(Date:8/28/2014)... by a Florida State University research team has led ... temperature, emit white light, and convert photon energy directly ... a butterfly. , Biwu Ma, associate professor in the ... College of Engineering, created the molecule in a lab ... that his creation has many other unique capabilities. , ...
(Date:8/28/2014)... 28, 2014 A new market ... world is available from Strategic Consulting, Inc., the ... Industrial Microbiology Market Review, Fourth Edition: Global Review ... (IMMR—4) tracks and compares microbiology test volumes, market ... Europe and Asia, and forecasts future volumes and ...
(Date:8/28/2014)... August 28, 2014 PrimeSource Building ... materials, selected SoundConnect to support their ... based audio and web conferencing platform GlobalMeet powered ... PrimeSource’s employees’ needs. SoundConnect delivers award winning ... PrimeSource Building Products will be utilizing GlobalMeet ...
Breaking Biology Technology:Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... Reported in CUSTOM I, II, and III ... ... ,XTENT, Inc. (Nasdaq: XTNT ) today announced positive long-term follow-up,data from ... the Custom NX(R) drug eluting stent (DES) system in treating,patients with coronary ...
... Proximity Systems ... WorkStations: one year later, ... 400,Proximity Systems Computer WorkStations, Centerpoint Medical Center offers,favorable reviews ... are satisfying the needs of the,hospital,s nurses, physicians, patients, ...
... Mentice, a leading,supplier of solutions for medical simulation, ... President of Global Marketing., Effective from today ... marketing activities globally from a corporate standpoint., ... of experience of global,sales, marketing and product management ...
Cached Biology Technology:Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 2Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 3In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 2In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 3In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 4Mentice Appoints Bjorn Larsson as Vice President of Global Marketing 2
... pressurized syringe holder for any researcher who needs: ... Microinjecting Fine microliter delivery Small ... any new or existing perfusion rig - from ... to house air or a compressor (30 to ...
...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
... Enterokinase (rEK) is a highly purified preparation ... a serine protease which recognizes the identical ... and has similar enzymatic activity. Novagen&'s enzyme ... and purified to yield the highest activity ...
Biology Products: