Navigation Links
The Burnham buzz
Date:12/8/2008

n: Designer Drugs to Block Breast Cancer

Gregory Roth, Ph.D., and colleagues have determined that a biologically active molecule called a chemokine promotes the spread of tumors, particularly in breast cancer. Dr. Roth believes that compounds that block the chemokine may be potential cancer therapies. However, existing small molecules that bind to chemokines only bind weakly, making them poor drug candidates. Dr. Roth and a team of Burnham chemists are working to custom-design molecules that bind tightly to the chemokine, hoping to block its activity and stop the spread of tumors.

Choking Out Cancer

Ze'ev Ronai, Ph.D. is trying to kill off cancer by choking it. When tumors are deprived of oxygen, they activate a transcription factor called HIF-1a that helps the tumor compensate and survive. Inhibiting HIF-1a has been hypothesized to be a means of defeating cancer, as tumors eventually experience oxygen deprivation due to insufficient blood flow to the tumor. Dr. Ronai's laboratory has demonstrated proof of this concept by inhibiting PHD3, a regulator of HIF-1a. Binding of short protein fragments to PHD3 results in HIF-1a degradation and halts growth of metastatic tumors in mice. Dr. Ronai's team is now investigating how small molecule compounds might accomplish the same thing.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Burnham researchers turn cancer friend into cancer foe
2. Burnham researcher awarded $8 million grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... from a team of Florida State University biologists could ... adapt to and survive environmental swings such as droughts ... issue of the journal The Plant Cell , ... and proteins) is organized in a cell and how ... turned on and others are turned off. , "If ...
(Date:11/5/2014)... – Kelly Redmond has dedicated his career to ... to a general audience. , As deputy director ... Center at Nevada,s Desert Research Institute, Redmond has ... management, application and dissemination of climate data to ... Fall Meeting in San Francisco on December 15-19, ...
(Date:11/4/2014)... 2014) — Think about the way our bodies are ... cells know that they are supposed to become a ... tissues find the correct place and alignment? Researchers at ... questions. , In a new study, UM researchers describe ... their surrounding neighbors, at the head-trunk region. Their discovery ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2The inside story: How the brain and skull stay together 2
... stranded for thousands of years on tiny islands surrounding Australia ... size of their mainland cousins. Now, new research in ... elapids was driven by the need to have big-mouthed babies. ... inches (89 cm) long, patrol swampy areas in search of ...
... Ottawa Hospital Research Institute (OHRI) and the University of Ottawa ... Snf2l have brains that are 35 per cent larger than ... in the prestigious journal Developmental Cell , could lead ... important insight into developmental disorders such as autism and Rett ...
... liver disease) is the most common type of liver disease ... US population. NAFLD is often associated with obesity and ... major risk factor for the development of cardiovascular disease. ... have demonstrated that modest alcohol consumption (an average of up ...
Cached Biology News:Big-mouthed babies drove the evolution of giant island snakes 2Big-mouthed babies drove the evolution of giant island snakes 3Mice with big brains provide insight into brain regeneration and developmental disorders 2
(Date:11/26/2014)... (PRWEB) November 25, 2014 SonaCare ... Focused Ultrasound (HIFU) devices, recently participated in the ... Renal Mass 360° .” Key opinion leaders in ... advances related to small renal masses while attendees ... different ablative technologies in hands-on labs. Attendees at ...
(Date:11/26/2014)... November 25, 2014 Continuing its award-winning ... earned three prestigious MarCom Awards for outstanding creative achievement ... a Platinum MarCom Award, the organization’s top honor, in ... St. Louis held in April of this year. The ... 14,000 attendees. Additionally, Nerium was awarded a Gold MarCom ...
(Date:11/26/2014)... Global biostimulants market is expected ... an estimated CAGR of 12.5%. In order to ... with least ecological impacts, farmers are looking to ... crop yield more effectively & efficiently. Biostimulants are ... the return on investments. , Leading companies in ...
(Date:11/26/2014)... Boston, MA (PRWEB) November 26, 2014 ... and collaboration company is proud to announce that Darren ... Development and Sales. Darren will drive the ... and positive customer experience. , Darren brings ... He has held key roles in channel operations, from ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4SoundConnect Appoints Director of Channel Development & Sales 2
... Oct. 7 Castle Access, Inc. announces the ... appointment aligns the Castle Access organization with that ... IT services provider, and gives clients in Southwestern ... of enterprise data center and mission-critical managed services. ...
... is developing and commercializing breakthrough single-molecule genomic analysis ... Officer, Han Cao, Ph.D., was awarded the Chinese ... Economic and Technical Cooperation Forum in Beijing, China ... recognition of Dr. Cao,s entrepreneurial spirit and success ...
... 7 GeneGo, Inc., a leading provider of databases, ... today that they have integrated GenomeQuest,s Sequence Data Management ... Using GenomeQuest,s interactive analysis, scientists who have drilled down ... of millions of reads, to thousands of expressed genes, ...
Cached Biology Technology:Castle Access Names New Managing Director 2Castle Access Names New Managing Director 3BioNanomatrix Founder and CSO Dr. Han Cao Awarded Chinese Rising Star Entrepreneur Award 2GeneGo Announces Integration With GenomeQuest for Pathway Analysis of Next Generation Sequencing Data 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Applications: Epitope mapping, Mapping protein-protein contacts, Identification of enzyme substrates/inhibitors, Identification of receptor agonists/antagonists...
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Biology Products: