Navigation Links
The Burnham Buzz, February 2009
Date:2/3/2009

Partnering for Progress

Burnham Institute for Medical Research (Burnham) has signed an assay development and license agreement with Johnson & Johnson Pharmaceutical Research and Development LLC. (J&JPRD). Under this multi-year agreement, Burnham will provide J&JPRD with access to high-throughput assay screening technologies to investigate certain drug targets for inflammatory diseases. The agreement is Burnham's first broad-based partnership with a large pharmaceutical company. Scientists at Burnham's Infectious and Inflammatory Disease Center are already using the institute's state-of-the-art robotic screening center in basic research programs.

Can you hear me now? Digital Drug Search

Giovanni Paternostro, M.D., Ph.D., and colleagues have developed a means to use search algorithms developed for the digital communications industry to identify drug combinations that are safe and effective. This novel approach involves algorithms that use biological measurements and model simulations to search for optimal drug combinations for the treatment of complex diseases such as cancer. In the study, a small subset of the drug combinations identified using the algorithms were tested in fruit fly and cancer cell model systems. Dr. Paternostro's research, published in the December 26, 2008 edition of PLoS Computational Biology, demonstrated that this approach can identify safe and effective drug combinations more rapidly that conventional methods. The conventional approach to finding drug combinations involves trial and error testing.

Gaining Control

Burnham scientists have identified the molecular machinery that regulates DNA replication and the S-phase checkpoint of the cell cycle. Wei Jiang, Ph.D., showed that the protein kinase complex known as Ddk is responsible for initiation of DNA replication, as well as controlling the S-phase of the cell cycle. If damaged DNA or a replication error is identified,
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Burnham researchers discover on switch for cell death signaling mechanism
2. The Burnham buzz
3. Burnham researchers turn cancer friend into cancer foe
4. Burnham researcher awarded $8 million grant
5. News from the February 2009 Journal of the American Dietetic Association
6. BioScience tip sheet, February 2009
7. February 2009 highlights from Biology of Reproduction
8. January-February GSA Bulletin media highlights
9. Media highlights for February in Biophysical Journal
10. Story tips from the Department of Energys Oak Ridge National Laboratory, February 2008
11. Highlights from the February 2008 Journal of the American Dietetic Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... need to produce hydrogen sulfide in order to properly ... study from the Center for Craniofacial Molecular Biology at ... Professor Songtao Shi, principal investigator on the project, said ... governs the flow of calcium ions. The essential ions ... osteogenesis, or the creation of new bone tissue, and ...
(Date:4/17/2014)... of forests in the Amazon help create tinderbox ... rapid and widespread forest loss during drought years, ... show that forests in the Amazon could reach ... forest fires lead to large-scale loss of trees, ... professor of geography, Penn State. , "We documented ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... (Washington, DC) The American Society for Bone and ... scientific meeting in the world on bone and mineral ... research, technology and new clinical treatments in bone diseases ... year,s Annual Meeting, being held in Baltimore, MD USA, ...
... 2013, Cleveland: Cleveland Clinic,s 8th Annual Obesity Summit will bring ... 17, 2013, at the InterContinental Hotel and Bank of America ... the escalating obesity epidemic in the United States. ... every six children are obese. In addition to causing health ...
... been vilified for detrimental effects to water quality and fish ... "ecological and engineering resilience" to climate change in the Columbia ... Canadian journal Atmosphere-Ocean , looked at the effects of ... reaches of seven sub-basins of the Columbia River from 1950 ...
Cached Biology News:American Society for Bone and Mineral Research Annual Meeting Oct. 4-7 2Cleveland Clinic's 2013 Obesity Summit explores causes, prevention and treatment of obesity 2Dams provide resilience to Columbia River basin from climate change impacts 2
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... selected by Buffalo BioBlower Technologies LLC ("B3") as the ... Phase 2 award from the Army Corps of Engineers.  ... that kills all biological contaminants and destroys VOCs and ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... , January 15, 2014 A study ... races on the Formula 1 track could help to tackle ... Applied Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... healthcare provider Simplyhealth. Telemetry technology, which is inspired ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... a provider of health-care and business technology, announced a seven-year ... Medicaid Management Information System (MMIS). The new system is expected ... in November, contracts EDS to implement its InterChange health system ... and Family Services . The contract is worth approximately $189 ...
... Inc. , a provider of education products in Wisconsin ... subsidiary's president, John Stearns. , ,Generation21 lost $4.6 million ... Renaissance Learning said it had looked for strategic alternatives ... to Stearns was its best option. , ,The company ...
... Greenspan, chairman of the Federal Reserve Bank, is famous ... (and sounding smart doing it). Recently however, he managed ... skills problem that now exists within the American workforce. ... his semi-annual report to Congress on February 12, 2005 ...
Cached Biology Technology:State picks long-time vendor for $189m Medicaid information system 2Is America prepared to win the global skills race? 2Is America prepared to win the global skills race? 3Is America prepared to win the global skills race? 4
... Roche Applied Science, which pioneered the ... Expand High Fidelity and Expand Long Template ... FidelityPLUS PCR System the first product ... This new blend combines Taq DNA ...
The HEPTEST assays provide a sensitive, simple, rapid, and convenient in vitro quantitation of heparin, low molecular weight heparins, and heparinoids in plasma and whole blood. Sample Type: wh...
...
... Synergistic enzyme mix (Thermoprime Plus DNA Polymerase ... least four times higher fidelity than standard ... standard Taq DNA polymerase, Amplifies DNA templates ... long PCR, PCR for cloning and mutagenesis ...
Biology Products: