Navigation Links
The American Society for Microbiology honors Susan Sharp
Date:6/7/2012

Washington, DCJune 6, 2012 Anthony R. Richardson, Ph.D., Assistant Professor, Department of Microbiology & Immunology, University of North Carolina Hill School of Medicine, has been honored with one of two 2012 Merck Irving S. Sigal Memorial Awards. These awards, given annually to two young scientists to recognize and award excellence in basic research in medical microbiology and infectious diseases, are presented in memory of Irving S. Sigal, an instrumental figure in the early discovery of therapies to treat HIV/AIDS. "Richardson is a remarkably imaginative scientist whose work bridges microbial physiology, metabolism, and pathogenesis," states his nominator, William Goldman from the University of North Carolina. "His approach is interdisciplinary and mechanistic, and his work has profound implications for understanding the evolution and emergence of highly virulent pathogens."

Richardson received his B.S. in genetic and bioengineering from Purdue University, and his Ph.D. in microbiology and molecular genetics from Emory University. He completed his postdoctoral fellowship in bacterial physiology and pathogenesis at the University of Washington, where he worked in the laboratory of Ferric Fang, who described Richardson as "extremely curious, interactive, and remarkably well readan exceedingly bright and creative scientist who is poised to make major contributions to the field of bacterial pathogenesis."

Richardson's research has always been focused on the role of basic bacterial physiology in the virulence of important human pathogens. As a graduate student, he investigated the role of DNA repair in modulating immune avoidance in epidemic meningococcal meningitis. His findings showed that the rapid host-to-host spread of Neisseria meningitidis in sub-Saharan Africa during seasonal epidemics selected for strains lacking certain aspects of DNA repair. Given the nature of N. menigitidis, this resulted in bacterial populations with extremely diversified surface immunogenicity facilitating rapid adaptation to new hosts.

As a postdoctoral fellow, Dr. Richardson continued studying bacterial metabolism in the context of its interaction with host innate immunity. He showed that host-production of nitric oxide (NO), a broad-spectrum immune effector, targeted multiple metabolic enzymes inhibiting the growth of pathogenic bacteria. In contrast, he found that the human pathogen Staphylococcus aureus, unlike all other tested bacteria including coagulase negative staphylococci, was able to resist the cytotoxic effects of host NO and thrive in its presence. S. aureus NO-resistance was shown to be essential for full virulence and hinged on the ability of the bacterium to evoke a metabolic state inherently resistant to the effects of this immune radical.

In 2008, Dr. Richardson established his laboratory at the University of North Carolina at Chapel Hill, focusing on the metabolic adaptations of S. aureus to host immunitywork that was soon featured as a Science cover article. Richardson's research studies how the availability of host arginine affects the outcomes of S. aureus infections. While the host converts free arginine to NO in response to inflammatory stimuli, arginine can also be converted to a class of compounds known as polyamines under similar conditions. S. aureus can resist the effects of NO, but for unknown reasons certain species of polyamines are lethal to the pathogen. Dr. Richardson's laboratory studies the battle between the host and S. aureus over the fate of free arginine. Mark Smeltzer, University of Arkansas for Medical Sciences, calls his work "both insightful and scientifically compelling, without exception."

Richardson's late graduate mentor, Igor Stojilijkovic, summarized Richardson to Fang: "He has a big brain, but his heart is even bigger. He is one of those rare individuals who you know will make it in any endeavor he chooses to follow."


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. The American Society for Microbiology honors Geoffrey L. Smith
2. The American Society for Microbiology honors I. Kaye Wachsmuth
3. The American Society for Microbiology honors Bess B. Ward
4. University of Tennessee anthropologists find American heads are getting larger
5. Steve Fisher joins American Health IT LLC as VP of Operations
6. The American Society for Microbiology honors Ellen Jo Baron
7. New study published on fertility awareness among American university students
8. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
9. Professor known for work with hunter-gatherers elected to American Academy of Arts and Sciences
10. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
11. American Society of Plant Biologists honors early career women scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... GUELPH, ON , June 27, 2016 /PRNewswire/ - BIOREM ... it has been advised by its major shareholders, Clean ... LP, United States based venture ... common shares of Biorem (on a fully diluted, as ... for the disposition of their entire equity holdings in ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the ... today the Clinical Reach Virtual Patient Encounter CONSULT module which enables both ... physician and clinical trial team. , Using the CONSULT module, patients and physicians can ...
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
Breaking Biology Technology: