Navigation Links
The American Society for Microbiology honors Marc Torrent
Date:6/18/2013

Marc Torrent, Ph.D., Medical Research Council, Laboratory of Molecular Biology, has been honored as a recipient of a 2013 ICAAC Young Investigator Award. Torrent is being recognized for his outstanding research, which includes developing the first algorithm to predict antimicrobial regions in proteins. Luis Rivas, Centro de Investigaciones Biolgicas(CSIC), said, "we are now applying this algorithm to interrogate full genomes in order to define new antimicrobial peptide leads with very appealing results."

Torrent obtained his Ph.D. from the Biochemistry and Molecular Biology Department at the Universitat Autnoma de Barcelona. During this time, he was interested in understanding the mechanism of action of antimicrobial proteins, particularly human ribonucleases. He was fascinated by the ability of a particular protein (RNase 3) to agglutinate gram-negative bacteria. His investigations revealed that RNase 3 was able to aggregate on the external layers of these pathogens in an amyloid-like manner. Failure to aggregate would cause the loss of agglutination. This was the first report of amyloid-like aggregates pursuing a defense function. During his time as a Ph.D. student at the Universitat Autnoma de Barcelona, Torrent worked under Ester Boix's supervision. She said Torrent, "has an outstanding capacity to work independently and develop new methodologies, contributing to our project with brilliant ideas."

After he completed his Ph.D., he worked as a postdoctoral researcher at the Universitat Pompeu Fabra where he expanded upon his interest in antimicrobial peptides by studying them from a chemical perspective. He directed his efforts to see whether antimicrobial proteins could be dissected in smaller peptides in order to be used as anti-infective drugs. He continued using ribonucleases as protein models and discovered that their antimicrobial properties were retained at specific domains that could be further dissected without losing activity. Later, he showed that these results could be generalized to include other proteins and developed computational tools to identify antimicrobial domains. These studies revealed, once more, that aggregation properties could modulate the activity of antimicrobial peptides. Hence, he directed his efforts to understand whether antimicrobial peptides could be related to amyloid-prone proteins. Surprisingly, his results suggested that antimicrobial peptides might have arisen during evolution after cationization of amyloid-prone sequences.

Presently, Torrent is a Marie Curie fellow at the Medical Research Council, Laboratory of Molecular Biology in Cambridge, England, where he is investigating the regulatory roles of tRNAs. These studies can help to understand, among other questions, how viruses manipulate tRNA populations to favor translation of their own proteins.


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
202-942-9389
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. American College of Rheumatology releases first classification criteria for polymyalagia rheumatica
2. Common North American frog identified as carrier of deadly amphibian disease
3. UC research tests new tool to guide reintroduction of the American chestnut
4. American Society of Plant Biologists honors early career women scientists
5. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
6. Professor known for work with hunter-gatherers elected to American Academy of Arts and Sciences
7. Elsevier selected as new publisher of the American Journal of Geriatric Psychiatry
8. New study published on fertility awareness among American university students
9. The American Society for Microbiology honors Ellen Jo Baron
10. Steve Fisher joins American Health IT LLC as VP of Operations
11. University of Tennessee anthropologists find American heads are getting larger
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... Feb. 24, 2017  EyeLock LLC, a leader of iris-based ... iris biometric solution on the latest Qualcomm® Snapdragon™ ... Mobile World Congress 2017 (February 27 – ... Hall 3, Stand 3E10. The ... security platform—a combination of hardware, software and ...
(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
(Date:2/13/2017)... , Feb. 13, 2017  RSA Conference -- ... platform that is designed to enhance fraud detection ... release in the RSA Fraud & Risk Intelligence ... organizations to leverage additional insights from internal and ... to better protect their customers from targeted cybercrime ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... March 21, 2017 , ... Proper ... information on the desired increase and/or decrease in antibody-dependent cellular cytotoxicity or complement-dependent ... profiling of therapeutic antibodies. , To meet this demand, the team at ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... has unveiled its innovative Quantum peristaltic pump with patented ReNu single-use (SU) ... the new standard for high-pressure feed pumps in SU tangential flow filtration ...
(Date:3/22/2017)... PETACH TIKVAH, Israel , March 22, ... leading developer of adult stem cell technologies for neurodegenerative ... Executive Officer, will provide an update on new developments ... Annual Neuroscience Biopartnering and Investment Forum, being held ... Academy of Sciences. ...
(Date:3/20/2017)... ... March 20, 2017 , ... SSCI and Whitehouse Laboratories, divisions of ... 2017 ! Sponsored by the Parenteral Drug Association (PDA), the New York Interphex ... industry professionals in attendance and more than 625 exhibitors, the educational and networking opportunities ...
Breaking Biology Technology: