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The American Society for Microbiology honors David Tobin
Date:8/22/2012

d genetic screens in zebrafish to identify factors influencing disease by the tuberculosis bacillus," explains nominator Raphael Valdivia, Duke University. "Tobin identified mutations associated with susceptibility to mycobacterial infection in zebrafish and defined the mechanism underlying this susceptibility. More impressively, he then showed that this information could be used to identify genetic variations in human populations that strongly correlated with susceptibility to tuberculosis and leprosy," Valdivia continued. "These variations predicted outcomes to therapeutic intervention, which he was then able to validate in zebrafish. His study is one of the most scientifically impressive ones I have seen in the field of infectious diseases."

In 2011, Tobin became an Assistant Professor in the Department of Molecular Genetics and Microbiology at Duke University. His laboratory at Duke studies the host response to mycobacterial infection using zebrafish, bacterial, and human genetics. "Tobin is at the forefront of a new field, where he will make seminal discoveries in TB pathogenesis based on real time observation of the dynamics of cellular immunity within a genetically tractable vertebrate system," claims Valdivia. Ramakrishnan concluded, "He is one of the most intelligent, intuitive, inventive and resourceful scientists I have ever encountered. These traits, coupled with his strong humanitarian predisposition, will lead him to continue his trajectory of making ground breaking discoveries that will impact the treatment of TB and other infectious diseases."


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Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

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