Navigation Links
The American Society for Microbiology honors Anthony R. Richardson
Date:6/7/2012

Washington, DCJune 6, 2012 Anthony R. Richardson, Ph.D., Assistant Professor, Department of Microbiology & Immunology, University of North Carolina Hill School of Medicine, has been honored with one of two 2012 Merck Irving S. Sigal Memorial Awards. These awards, given annually to two young scientists to recognize and award excellence in basic research in medical microbiology and infectious diseases, are presented in memory of Irving S. Sigal, an instrumental figure in the early discovery of therapies to treat HIV/AIDS. "Richardson is a remarkably imaginative scientist whose work bridges microbial physiology, metabolism, and pathogenesis," states his nominator, William Goldman from the University of North Carolina. "His approach is interdisciplinary and mechanistic, and his work has profound implications for understanding the evolution and emergence of highly virulent pathogens."

Richardson received his B.S. in genetic and bioengineering from Purdue University, and his Ph.D. in microbiology and molecular genetics from Emory University. He completed his postdoctoral fellowship in bacterial physiology and pathogenesis at the University of Washington, where he worked in the laboratory of Ferric Fang, who described Richardson as "extremely curious, interactive, and remarkably well readan exceedingly bright and creative scientist who is poised to make major contributions to the field of bacterial pathogenesis."

Richardson's research has always been focused on the role of basic bacterial physiology in the virulence of important human pathogens. As a graduate student, he investigated the role of DNA repair in modulating immune avoidance in epidemic meningococcal meningitis. His findings showed that the rapid host-to-host spread of Neisseria meningitidis in sub-Saharan Africa during seasonal epidemics selected for strains lacking certain aspects of DNA repair. Given the nature of N. menigitidis, this resulted in bacterial populations with extremely diversified surface immunogenicity facilitating rapid adaptation to new hosts.

As a postdoctoral fellow, Dr. Richardson continued studying bacterial metabolism in the context of its interaction with host innate immunity. He showed that host-production of nitric oxide (NO), a broad-spectrum immune effector, targeted multiple metabolic enzymes inhibiting the growth of pathogenic bacteria. In contrast, he found that the human pathogen Staphylococcus aureus, unlike all other tested bacteria including coagulase negative staphylococci, was able to resist the cytotoxic effects of host NO and thrive in its presence. S. aureus NO-resistance was shown to be essential for full virulence and hinged on the ability of the bacterium to evoke a metabolic state inherently resistant to the effects of this immune radical.

In 2008, Dr. Richardson established his laboratory at the University of North Carolina at Chapel Hill, focusing on the metabolic adaptations of S. aureus to host immunitywork that was soon featured as a Science cover article. Richardson's research studies how the availability of host arginine affects the outcomes of S. aureus infections. While the host converts free arginine to NO in response to inflammatory stimuli, arginine can also be converted to a class of compounds known as polyamines under similar conditions. S. aureus can resist the effects of NO, but for unknown reasons certain species of polyamines are lethal to the pathogen. Dr. Richardson's laboratory studies the battle between the host and S. aureus over the fate of free arginine. Mark Smeltzer, University of Arkansas for Medical Sciences, calls his work "both insightful and scientifically compelling, without exception."

Richardson's late graduate mentor, Igor Stojilijkovic, summarized Richardson to Fang: "He has a big brain, but his heart is even bigger. He is one of those rare individuals who you know will make it in any endeavor he chooses to follow."


'/>"/>

Contact: Garth Hogan
ghogan@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. News from the October 2008 Journal of the American Dietetic Association
2. American Chemical Societys Weekly PressPac -- Sept. 24, 2008
3. Nanotech and synbio: Americans dont know whats coming
4. American Chemical Societys Weekly PressPac
5. American College of Medical Genetics receives $13.5M NIH contract
6. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
7. American Chemical Society Weekly PressPac Oct. 15, 2008
8. Scientists map soils on an extinct American volcano
9. Indiana University research at American Public Health Association meeting
10. North American environmental commission launches trinational vaquita conservation plan
11. News from the November 2008 Journal of the American Dietetic Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... Summary This report provides all ... and its partnering interests and activities since 2010. ... The Partnering Deals and Alliance since 2010 report provides ... of the world,s leading life sciences companies. ... ensure inclusion of the most up to date deal ...
(Date:2/28/2017)... , February 28, 2017 News solutions ... ... Amsterdam from 14 to 16 March, Materna will ... and show how seamless travel is a real benefit for passengers. ... added biometrics to their passenger touch point solutions to take passengers ...
(Date:2/22/2017)... 22, 2017 With the biometrics market ... identifies four technologies that innovative and agile startups ... share in the changing competitive landscape: multifactor authentication ...   "Companies can no longer afford ... says Dimitrios Pavlakis , Industry Analyst at ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... , March 24, 2017 Agenus Inc. (NASDAQ: ... checkpoint antibodies and cancer vaccines, today announced participation at ... th  Annual William Blair and Maidstone Life Sciences conference ... Center in New York, NY . ... March 29 at 9:40 am: Robert B. Stein ...
(Date:3/23/2017)... ... 23, 2017 , ... Lajollacooks4u is proud to announce it has become the premiere team-building cooking ... for companies around the world, such as Illumina, HP and Qualcomm, and is ranked #1 ... increasing popularity is due to its new team building format, a way for teams to ...
(Date:3/23/2017)...  Northwest Biotherapeutics (OTCQB: NWBO) (NW Bio), a ... solid tumor cancers, today announced that yesterday it ... last Friday, March 17, 2017. ... totaling 28,843,692 shares, comprised of 18,843,692 common shares ... Class C Warrants pre-funded at the closing at ...
(Date:3/23/2017)...  GlobeImmune, Inc. today announced it has entered into ... shares of its common stock to NantCell, Inc., a ... the sale of its common stock, NantCell has agreed ... GlobeImmune 200,000 shares, an estimated $2.0 million in value, ... pleased to enter into this strategic agreement with NantCell," ...
Breaking Biology Technology: