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Texas Biomed gains $2.7 million NIH grant to research genetic basis of diseases
Date:8/15/2014

SAN ANTONIO, August 15, 2014 The Texas Biomedical Research Institute has been awarded a $2.7 million grant from the U.S. National Institutes of Health to fund innovative approaches to genetics research aimed at developing new therapies for heart disease and other conditions with genetic components.

The research builds on genetic studies conducted over the past decade by scientists around the world and at Texas Biomed that have helped identify large numbers of differences in the sequence of the human genome that are contributing to a wide range of diseases. The challenge that remains is understanding how these changes in the DNA sequence specifically affect the cells in the body, and lead to obesity, diabetes, heart disease or even neurological disorders such as Parkinson's disease. Once scientists understand the underlying mechanisms, they may be able to develop new therapies and actually improve treatment for these diseases.

To accelerate this process, the National Institute for General Medical Sciences (NIGMS) of the National Institutes of Health requested proposals from researchers to develop novel and innovative approaches that will help decipher the function of these specific genome sequence changes, and now awarded Michael Olivier, Ph.D., Texas Biomed's newest recruit to the Department of Genetics, a new 4-year grant to develop and implement such technologies. His laboratory specifically focuses on developing new ways to study how proteins little machines in cells that do everything, from producing energy to sending signals to other cells to recognizing and responding to challenges such as fat in the diet interact with the DNA in our cells to regulate the expression of genes.

Genes can be turned on or off, depending on whether a cell needs more or less of a specific protein, and this complex regulation is influenced by a large number of other proteins that bind to the DNA and regulate it. These regulatory proteins bind to s
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Contact: Mary Uhlig
muhlig@dublinandassociates.com
210-227-0221
Texas Biomedical Research Institute
Source:Eurekalert

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