Navigation Links
Texas Biomed files patent for a novel HIV vaccine strategy
Date:11/19/2012

The Texas Biomedical Research Institute in San Antonio has applied for a patent for a genetically-engineered vaccine strategy to prevent HIV infection that targets the outer layers of body structures that are the first sites of contact with the virus.

Designed to be a single dose and last a lifetime, the vaccine will lead to the continual production of disease-fighting cells without being eliminated by the immune system. Another feature of the vaccine system is that it could be adapted for use against other infections.

More than 90 percent of new HIV infections worldwide are transmitted by sexual intercourse through outer layers of cells called epithelial cells which line the surfaces of structures throughout the body. The new vaccine is directed to what are known as the mucosal layers of the epithelium in the genital and rectal areas where the virus enters the body.

"The development of an effective AIDS vaccine that restricts viral replication at the mucosal level of entry may be our best hope for controlling the HIV pandemic," said Marie-Claire Gauduin, Ph.D., of Texas Biomed's Department of Virology and Immunology, who is a co-inventor on the patent with Philippe Blancou, Ph.D., a visiting scientist from the University of Nice-Sophia Antipolis, France. "Only life-long stimulation of the immune system by the vaccine will be sufficient to achieve long-term protection," she added.

One of the main reasons for the failure of HIV vaccines thus far is their inability to deliver antibody-producing cells for prolonged periods of time, thus only achieving weak and transient protection at best.

The primary target for viral transmission through different mucosal sites varies depending on the tissue. However, soon after crossing the mucosal layer, HIV rapidly spreads to lymph nodes and other organs where it replicates.

The vaccine will have a molecule and stem cell gene tagged to target epithelial cells, that combined, will promote the production of antibody-producing cells. Thus, the epithelial layer will continuously release new antibody-producing cells and not be eliminated by the body's immune response.
'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9537
Texas Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Texas cotton getting a genetic tune-up
2. Texas Biomed reports faster, more economical method for detecting bioterror threats
3. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
4. EyeLock Inc. Brings High-Tech Iris Biometric Production to Texas
5. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
6. Controlling gait of horses may be possible, says key study from Texas A&M
7. BP Biofuels, Texas AgriLife Research sign agreement to advance biofuel feedstock development
8. NSBRI renews space life sciences graduate programs at MIT, Texas A&M
9. University of Texas Medical Branch selected to manage Center for Polar Medical Operations
10. Mining cleanup benefits from Texas A&M expertise
11. Diet of early human relative Australopithecus shows surprises, says Texas A&M researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... YORK , December 5, 2016 ... player worldwide, with almost $108 billion of revenue and ... $170 billion were spent on global biopharmaceuticals, and this ... This morning, Stock-Callers.com has lined up these four equities ... ), ACADIA Pharmaceuticals Inc. (NASDAQ: ACAD ), ...
(Date:12/4/2016)... ... December 03, 2016 , ... Microbial genomics ... impact grant award has been made to Dr. Renato Polimanti of Yale University ... on the oral microbiome. Grant proposals have been vetted by the company’s scientific ...
(Date:12/4/2016)... Mass. and CAMBRIDGE, Mass. ... Africa , Dec. 4, 2016 ... providing connected diagnostics software platforms for the developing ... making "Anywhere. Care.™" a reality with its portable ... have entered into a development and license agreement ...
(Date:12/2/2016)... 2, 2016 More than $4.3 million was raised ... ( DHMD ). The gala was held at the American ... City and honored Alan Alda and ... health and medicine and the public understanding of science. Since ... the event has raised $40 million for the Laboratory,s research ...
Breaking Biology Technology: