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Texas A&M researchers develop tool to study complex clusters of genes
Date:7/2/2008

said. "They can then analyze the differences in the operon in the different bacteria and see if there are any interesting relationships."

Sze said his and Yang's tool is an improvement on previous methods because it is a new way to analyze many bacterial genomes at the same time. It is also more accurate than previous methods in which scientists start by simply using a statistical method to predict the location of an operon in a bacterial genome. Sze and Yang, however, show that it is more accurate to start from a known and experimentally validated E. coli operon to find similar operons in other bacteria.

"Eventually, we want to try to improve our tool to make it better and more accurate," Sze said. "Although our tool can analyze a lot of bacteria at the same time, it compares each bacterium to E. coli separately. So the ultimate goal would be to develop a tool that will analyze them all together."


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Contact: Sing-Hoi Sze
shsze@tamu.edu
979-845-5009
Texas A&M University
Source:Eurekalert

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